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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A therapeutic approach for potential prevention of aromatase inhibitor-induced bone loss

    SBC: NANOMEDIC INC            Topic: NIA

    AbstractIn this SBIR Phase I applicationour goal is to demonstrate proof of concept of our lead chelating agent as a potential therapeutic for the prevention of osteoporosis induced by aromatase inhibitorAItherapy in postmenopausal women with hormone receptor positive breast cancerAlthough AI therapy shows great improvements in cancer free and overall survivalits treated patients face a risk of os ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Daily and localized NSAID sonophoresis for symptomatic treatment of knee osteoarthritis

    SBC: Zetroz Systems LLC            Topic: NIA

    Project SummaryOsteoarthritisOAis the most common type of arthritisaffecting overmillion adults in the United States inand represents overof medical office visits according to the Centers for Disease Control and Prevention and the National Institutes of HealthOverof individuals overhave symptomatic OA and reduced mobility due to the diseaseOA pain is often mitigated with conservative treatment app ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Single-cell Phosphoprotein Assay to Evaluate Brain Tumor Therapeutic Resistance

    SBC: ISOPLEXIS CORPORATION            Topic: 102

    Although signal transduction inhibitors occasionally offer clinical benefit for cancer patientssignal flux emanating from oncogenes is often distributed through multiple pathwayspotentially underlying the resistance which causes failure of most such inhibitorsMeasuring signal flux through multiple pathwaysin response to signal transduction inhibitorsmay help uncover network interactions that contr ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Use of Stem Cells to Enhance and Extend Continuous Glucose Monitoring in Vivo

    SBC: Cell And Molecular Tissue Engineering LLC            Topic: 200

    Implantable glucose sensor based monitoring of blood glucose levels in diabetic patients has been available for overyearsHoweverdespite improvements to sensor functionalityrecalibration of the sensor device is often a necessity in order to compensate for unreliable sensor performanceThe development of highly accurate and long lived implantable sensors is critical to the development of theartificia ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Development of an a MC1R selective companion diagnostic imaging probe

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    The melanocortinreceptorMC Ris over expressed on uveal and cutaneous melanoma cellsbut notin healthy normal tissuesWe have developed a proprietary ligandMTIthat binds to MC R inmelanoma cells with high affinity and specificityThrough our SBIR Phase I contractwedemonstrated that MC R targetedAc DOTA MTIlacks of overt toxicity at single doses thatproduce significant efficacy against uveal and cutane ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. 1-D Titania Nanostructure Based Wearable Alcohol Sensor with Tunable Sensitivity and Artificial Intelligence

    SBC: NanoSynth Materials and Sensors Inc.            Topic: 450

    PROJECT SUMMARY The overarching goal of this proposal is to develop an artificially intelligent alcohol sensor that is wearablenoninvasivesmartand aestheticThe aimin Phase Iis to design and develop the alcohol sensor based on metali eCobaltfunctionalized Titanium nanotubesTiNTto detectmonitorand display blood alcohol levels in real time using microcontrollers based wrist band like devicesAt the co ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. A Combined High-Throughput Single-Cell Transcriptomic and Secretomic Assay for Neurodegenerative Disease Biomarker Discovery

    SBC: ISOPLEXIS CORPORATION            Topic: 105

    In this Phase I application IsoPlexis proposes to deliver a novel method for targeted profiling of both the transcriptome and secretome from an array ofsingle central and peripheral immune cellsSpecificallywe will deliver a single cellmRNA and secreted protein capture assay with proven sensitivity for detecting the most important predictive biomarkers for neurodegenerative diseasesThere is growing ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. ARF6 Inhibitor as Adjunctive Therapy for Treatment of SA Bacteremia

    SBC: NAVIGEN, INC.            Topic: NIAID

    PROJECT SUMMARYStaphylococcus aureus bacteremiaSABis one of the most common blood stream infections and has mortality rates ofor higherThe pathogenicity of SAB is due to various virulence factors which facilitate microbial colonization of the host and contribute to immune evasionThese virulence factors elicit a host response that can include a severe systemic inflammatory reactioncytokine stormand ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. High sensitivity tethered bichromophoric voltage-sensitive dyes

    SBC: POTENTIOMETRIC PROBES LLC            Topic: 101

    Project Summary Abstract Potentiometric Probes Voltage sensitive dyes can be applied to brain cells and tissue to study the electrical signals used by the brain to functionThe fluorescent dye molecules light up under a microscope and convert tiny electrical signals to measurable changes in light intensityAll neurological disorders involve changes in the brain s normal electrical activity and can p ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Bioengineered skin microbiota for cutaneous mitigation of Netherton Syndrome

    SBC: Azitra Inc.            Topic: NIAMS

    PROJECT SUMMARY Current treatment options for many skin diseases especially rare diseases fail to address the underlying causative pathophysiologiesIn the case of genetic mutations that cause loss of function mutationssupplementing the missing protein is a viable approach to treatmentHoweverdelivery of functional protein to the target keratinocytes presents a significant challengemoreoverthe cost ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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