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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Innovative Continuous Sanitization of Fresh Produce Harvesting Equipment

    SBC: En Solucion Inc            Topic: FDA

    Recent foodborne illness outbreaks traced to contaminated field harvesting equipment have highlighted the need for incorporating improved sanitization practices at the time of harvest. Field- harvested specialty crops represent 50% of the top ten foods linked to major recalls and outbreaks over the past five years. Proper sanitization of outdoor harvest equipment is made complicated by operational ...

    SBIR Phase I 2023 Department of Health and Human ServicesFood and Drug Administration
  2. Geostatistical Software for Non-Parametric Geostatistical Modeling of Uncertainty

    SBC: BIO-ANALYTICS, INC.            Topic: NLM

    7. Project Summary/Abstract A key component in any investigation of association and/or cause-effect relationships between the environment and health outcomes is the availability of accurate and precise models of exposure. Because the cost of collecting field data is often prohibitive, it is critical to incorporate any source of secondary information available to supplement sparse datasets. Seconda ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. 3D Printed Silicon Nitride Porous PEEK Composite Spinal Cages for Anti-Infection

    SBC: SINTX TECHNOLOGIES, INC.            Topic: NIAMS

    PROJECT SUMMARYSpinal fusion is the standard treatment for persistent neck and back pain, but the hardware used to stabilize the fusion can harbor or even promote bacteria that lead to persistent, difficult-to-treat infections that are costly and damaging to patient health. Among the available materials for spinal fusion, polyether-ether-ketone (PEEK) cages stand out due to their strength, biocomp ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. A Potent D-peptide Inhibitor of TNFα for Treatment of Rheumatoid Arthritis

    SBC: D BioTherapeutics, LLC            Topic: NIAMS

    Rheumatoid arthritis (RA) is a chronic, debilitating inflammatory disease with high medical and societal costs afflicting more than 1.6 million Americans. Blockade of TNFα-driven inflammation with approved anti-TNFα biologics (such as Humira®, Remicade®, Simponi®, and Enbrel®) is an effective treatment for many patients suffering from RA. However, due at least in part to the immunogenicity o ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Novel Extracorporeal Device 'Amytrapper' To Remove Beta Amyloid In Alzheimer'sDisease

    SBC: Recombinant Technologies LLC            Topic: NIA

    Abstract Alzheimer’s disease is the most common cause of dementia and fourth most common cause of death. Amyloid-beta (Aβ) plays a crucial role in initiation and progression of Alzheimer’s disease (AD). Removal of circulating Aβ would shift the equilibrium in Aβ levels between brain and blood towards blood. This shift would deplete brain amyloid levels and improve memory. Three commercial m ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Commercial translation of high-density carbon fiber electrode arrays for multi-modal analysis of neural microcircuits

    SBC: BLACKROCK MICROSYSTEMS, INC            Topic: 106

    ABSTRACT The ability to measure and manipulate local brain circuit activity in living, behaving animals is essential to understanding the complexities of brain function and dysfunction. A novel, penetrating high-density carbon fiber electrode array composed of flexible, ultrathin conductive carbon microfibers was recently developed under the BRAIN Initiative to study neural microcircuit dynamics. ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Method for the validation by Western analysis of affinity reagents against post-translationally modified proteins.

    SBC: ABBRATECH INC.            Topic: 400

    ABSTRACT Antibodies (Abs) are commonly employed in biomedical research to identify and quantify target proteins. However, the specificity, sensitivity and reliability of these Abs can be variable, which is a significant concern in the scientific community. The use of an incorrect Ab can result in misleading or inaccurate results, impeding progress in various areas of biomedical research. In Phase ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. PET Imaging of Damaging Neuroinflammation in Alzheimer's Disease

    SBC: EINSENCA INC.            Topic: NIA

    Alzheimer's disease (AD) is a devastating and progressive disease without a cure. Neuroinflammation is now recognized as a key early event in the development of AD. Aberrant neuroinflammatory response activates immune cells that can increase oxidative stress, and oxidative stress can directly damage neurons and axons, cause demyelination, and break down the blood-brain barrier (BBB). Thus, damagin ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Modular Virtual Reality Therapeutic for Opioid and Stimulant Use Disorders

    SBC: INNATEVR LLC            Topic: NIDA

    PROJECT SUMMARY Opioid and/or Stimulant Use Disorders (OUD/StUD) are chronic, recurring conditions that if left untreated, pose a significant and ongoing public health and safety threat, with costs associated with OUD alone in the US exceeding one trillion dollars annually. Virtual Reality Cue Exposure (VRCE) employs safe and controlled repeated exposure to a variety of substance use cues and envi ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a sample preparation protocol for 3D kidney ultrastructural analysis and immunolabeling by light microscopy

    SBC: panluminate Inc.            Topic: 400

    Abstract The success of cohort studies such as the NIDDK Kidney Precision Medicine Project (KPMP) with its massive amount of samples depends on the cost and time-efficient evaluation of kidney biopsies at multiple scales. Assessing the structure of kidney tissue at the nanoscale (~10 nm) and evaluating the 3-D distribution of protein biomarkers in that context is, however, currently severely limit ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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