Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A circular array desktop ultrasound tomography system for cross sectional imaging of small animals

    SBC: Sonamed Technologies, LLC            Topic: 100

    The long term goal of the proposed project is the development of a desktop circular array Small Animal Ultrasound Tomography System SAUTS to produce high resolution cross sectional diagnostic images of mice and other small laboratory animals The SAUTS images will look familiar to the radiologist resembling those produced by Micro CT or MRI They will be easy to interpret as the circular tomog ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A high resolution and high DQE detector optimized for mammography using single-shot bi-directional tri-contrast imaging

    SBC: Sigray, Inc.            Topic: NIBIB

    DESCRIPTION provided by applicant X ray tricontrast imaging provides three different modes of contrast absorption contrast the mechanism behind how conventional medical X ray imaging equipment images phase contrast which provides up to X more contrast than absorption based contrast for soft tissue and scatter contrast which provides information of features at dimensions smaller than ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. A new approach to fast, diagnostic-quality, intraoperative microscopic examination

    SBC: Applikate Technologies LLC            Topic: NIBIB

    DESCRIPTION provided by applicant The goal of this Phase I SBIR proposal from Applikate Technologies LLC is to validate and optimize RapidView a novel approach to intraoperative microscopic analysis of excised tissue Currently pathologists analyze flash frozen tissue sections to provide immediate histological evaluation of surgical excisions for million operations per year in the United ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. A New Co Expressed P and UGT Platform for the Simultaneous Preparation of P Metabolites and Their Glucuronides

    SBC: OXFORD BIOMEDICAL RESEARCH, INC.            Topic: 300

    Toxins pharmaceuticals and physiologically indogenous compounds are metabolized by the liver via several classes of enzymes The uridine diphosphate glucuronosyltransferases UGTs are concentrated in the liver but also present in other tissues These enzymes add UDP glucuronic acid UDPGA to a compound thereby increasing its solubility and ability to be excreted in the bile and urine Oxford B ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. A Platform for Safe Noninvasive Prenatal Genetic Testing at Five Weeks of Pregnancy

    SBC: Cradle Genomics, Inc.            Topic: NICHD

    SUMMARY The overall goal of this research is to provide a flexible prenatal genetic testing kit that can be expanded to detect any inheritable trait as early as and up to weeks of gestation from a safe noninvasive Pap smear Studies show that perinatal Pap tests pose no risk to mother or fetus and capture trophoblast like cells that migrate from the placenta into the reproduct ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A Rapid Low Cost Point of Care Diagnostic for detection of Zika virus RNA

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    ABSTRACT Zika virus ZIKV has rapidly emerged and spread through South and Central America the Caribbean and Puerto Rico since its last outbreak in Micronesia in Transmitted by the mosquito Aedes sp its forecasted spread will have a major impact on the Southeast U S Most ZIKV infections remain asymptomatic or present with non specific rash and fever therefore they have been difficult ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A Single Cell Multi-Protein Device to Facilitate Cancer Immunotherapy

    SBC: IsoPlexis            Topic: 102

    DESCRIPTION provided by applicant The most promising immunotherapies against cancer rely upon modulating CD and various CD T cells to activate against cancers like melanoma lymphoma and leukemia However the ability for researchers to measure the secreted effector proteins per heterogeneous T cell which determine the cellular potency against the cancer is limited today This Phase ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. A Small Molecule Drug Discovery Platform to Target Cancer Causing microRNAs

    SBC: NYMIRUM, INC.            Topic: 102

    Project Summary Abstract The pharmaceutical and biotech industries are targeting various RNA classes to develop new drugs MicroRNAs miRNAs participate in widespread regulation of cell function and contribute to a spectrum of human diseases especially cancer making miRNAs a drug target class of particular interest Due to delivery issues and poor bioavailability oligonucleotides based therapi ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Accessible And Robust Tools for Glycosaminoglycan Profiling

    SBC: ECHELON BIOSCIENCES, INC.            Topic: 300

    GlycosaminoglycansGAGsare polysaccharides composed of a repeated disaccharide subunit and known to be important for the maintenance of structure and mechanical properties of the extracellular matrixMore recentlychanges in the contentsizeand composition of GAGs have been found to play biological roles in disease processes as wellFor examplechondroitin sulfateCSis the most abundant GAGhoweveronly th ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Active Variable-Stiffness Prosthetic Foot

    SBC: INTELLIGENT PROSTHETIC SYSTEMS, LLC            Topic: NICHD

    DESCRIPTION provided by applicant The long term goal of this project is to develop prosthetic foot technology that can function differently for different activities Although current prostheses can be very effective for particular tasks e g walking running or standing an amputee must choose a single prosthesis to achieve reasonably good performance across all daily activities This resul ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
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