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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Geostatistical Software for Non-Parametric Geostatistical Modeling of Uncertainty

    SBC: BIO-ANALYTICS, INC.            Topic: NLM

    7. Project Summary/Abstract A key component in any investigation of association and/or cause-effect relationships between the environment and health outcomes is the availability of accurate and precise models of exposure. Because the cost of collecting field data is often prohibitive, it is critical to incorporate any source of secondary information available to supplement sparse datasets. Seconda ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. A Potent D-peptide Inhibitor of TNFα for Treatment of Rheumatoid Arthritis

    SBC: D BioTherapeutics, LLC            Topic: NIAMS

    Rheumatoid arthritis (RA) is a chronic, debilitating inflammatory disease with high medical and societal costs afflicting more than 1.6 million Americans. Blockade of TNFα-driven inflammation with approved anti-TNFα biologics (such as Humira®, Remicade®, Simponi®, and Enbrel®) is an effective treatment for many patients suffering from RA. However, due at least in part to the immunogenicity o ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Modular Virtual Reality Therapeutic for Opioid and Stimulant Use Disorders

    SBC: INNATEVR LLC            Topic: NIDA

    PROJECT SUMMARY Opioid and/or Stimulant Use Disorders (OUD/StUD) are chronic, recurring conditions that if left untreated, pose a significant and ongoing public health and safety threat, with costs associated with OUD alone in the US exceeding one trillion dollars annually. Virtual Reality Cue Exposure (VRCE) employs safe and controlled repeated exposure to a variety of substance use cues and envi ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a sample preparation protocol for 3D kidney ultrastructural analysis and immunolabeling by light microscopy

    SBC: panluminate Inc.            Topic: 400

    Abstract The success of cohort studies such as the NIDDK Kidney Precision Medicine Project (KPMP) with its massive amount of samples depends on the cost and time-efficient evaluation of kidney biopsies at multiple scales. Assessing the structure of kidney tissue at the nanoscale (~10 nm) and evaluating the 3-D distribution of protein biomarkers in that context is, however, currently severely limit ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Multisensory Augmented Reality as a bridge to audio-only accommodations for inclusive STEM interactive digital media

    SBC: ALCHEMIE SOLUTIONS, INC.            Topic: 500

    Only 3% of individuals who are blind or have low vision (BLV) have been employed in a STEM field. The lack of accessible accommodations to visually rich dynamic STEM content creates roadblocks to success for BLV students in STEM education throughout their academic journey. The goal of this SBIR is a usable system of accommodations for Interactive Digital Media (IDM), so students with profound visu ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. PANK Activators for the treatment of pantothenate kinase-associated neurodegeneration

    SBC: Virtus Therapeutics Corporation            Topic: NINDS

    SUMMARY Pantothenate kinase-associated neurodegeneration, PKAN, is a rare progressive neurodegenerative disorder associated with iron accumulation in the brain. The disease causes early immobility and often death by early adulthood. PKAN is caused by mutations in one of four human pantothenate kinase genes, PANK2 gene, which encodes a mitochondrial pantothenate kinase. Consistent with the clinical ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Biomechanical Evaluation of a Novel, Compliant Low Profile Prosthetic Foot

    SBC: LITTLE ROOM INNOVATIONS LLC            Topic: NICHD

    PROJECT SUMMARYWhile conventional wisdom holds that individuals with longer residual limbs retain greater function, they are actually confined to low-profile feet that limit performance. In particular, low-profile feet are often much stiffer than their standard profile counterparts. As such, many of the individuals with transtibial amputation that have long residual limbs are unable to obtain pros ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Novel Epigenetic Test for the Treatment and Improvement of Longitudinal Health-Outcomes for Men with Severe Infertility

    SBC: INHERENT BIOSCIENCES, INC.            Topic: NICHD

    NIH SBIR Fast-Track Application: Inherent Biosciences SUMMARY/ABSTRACT Title: Novel Epigenetic Test for the Treatment and Improvement of Longitudinal Health-Outcomes for Men with Severe Infertility39.7 million men worldwide (1% of the male population) suffer the severest form of male infertility: Non-Obstructive Azoospermia (NOA). These men have no identifiable sperm in their semen, greatly limiti ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Development of an endometrial ablation drug-device combination to treat heavy menstrual bleeding

    SBC: GYNION, LLC            Topic: NICHD

    PROJECT SUMMARY Over 10 million women in the US and 100 million women globally suffer from Heavy Menstrual Bleeding (HMB). Oral medications lack effectiveness and, like hormonal IUDs (intrauterine devices), have significant side effects. Currently available endometrial ablation options, which is another therapeutic alternative, are complex and require advanced anesthesia, which significantly limit ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Seaweed-based bioplastic replacement for commercial lobster fishing gear.

    SBC: VIABLE GEAR LLC            Topic: 93

    Viable Gear will provide proof-of-concept for a seaweed-based bioplastic to be used in manufacturing a compostable biotwine for marine equipment, designed to replace petroleum-based plastics. This addresses NOM-SBIR research topic area 9.3, The Changing Ocean - specifically to "support increased protection and restoration of marine and coastal habitats to enhance vital ecosystems", by helping decr ...

    SBIR Phase I 2023 Department of CommerceNational Oceanic and Atmospheric Administration
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