Award Data

DESCRIPTION provided by applicant We propose to evaluate the functionality MRI and bio compatibility of probes for microscopic magnetic stimulation mMS a new brain stimulation technology Moreover it has been demonstrated that the orientation of the applied MS fields relative to the excitable tissue provides unique activation of neuronal elements not seen with traditional electrical st ...

DESCRIPTION provided by applicant The objective of this proposal is to design develop and validate a commercially viable andquot human useandquot smart channel macro andamp micro ECoG microsystem with integrated recording stimulation and impedance measuring capabilities for epilepsy monitoring The microsystem comprises of a state of art microelectronic signal processing component lin ...

DESCRIPTION provided by applicant Shiga toxins and Stx are the primary virulence factors of Shiga toxin producing E coli STEC which are major food and waterborne pathogens afflicting both developed and developing countries An estimated STEC infections occur annually in the US In addition to severe and often bloody diarrhea the life threatening complication hemolytic ur ...

DESCRIPTION provided by applicant Methicillin resistant staphylococcus aureus MRSA is a serious pathogen that can cause patient mortality and extend hospital stays resulting in higher health care costs Currently over of staph cases around the world are caused by MRSA In recent years MRSA has evolved into several resistant strains that can resist to multiple antibiotics such as penic ...

DESCRIPTION provided by applicant This is a Phase I SBIR Application entitled andquot Novel Inhibitors of Multi Drug Resistant Mutants of BCR ABL for the Treatment of Chronic Myelogenous Leukemia CML and Ph Acute Lymphocytic Leukemia ALL andquot The overall goal of this proposal is to further optimize and improve the efficacy of novel classes of compounds discovered developed and patent ...

DESCRIPTION provided by applicant Cornelia de Lange Syndrome is a complex congenital malformations syndrome with many post natal progressive medical complications CdLS has a clear genetic cause with loss of function mutations in NIPBL accounting for over of the genetically confirmed CdLS cases The remaining cases exhibit mutations in subunits or regulators of the cohesion complex SMC S ...

DESCRIPTION provided by applicant This is a Phase I SBIR Application entitled andquot Isolation and Characterization of Low Molecular Weight Compounds Derived from Plant Extracts that Activate the IRS Dependent Insulin Signaling Cascade andquot Diabetes is a growing and significant global health concern Insulin Receptor Substrate IRS is a critical component in the insulin mediated s ...

DESCRIPTION provided by applicant Type diabetes is an immune mediated disease in which insulin producing beta cells are destroyed resulting in life long dependence on exogenous insulin The number of patients being diagnosed is increasing each year particularly in the very young Despite advances in glucose monitoring and insulin delivery there is a compelling need to identify therapies th ...

DESCRIPTION provided by applicant The most promising immunotherapies against cancer rely upon modulating CD and various CD T cells to activate against cancers like melanoma lymphoma and leukemia However the ability for researchers to measure the secreted effector proteins per heterogeneous T cell which determine the cellular potency against the cancer is limited today This Phase ...

DESCRIPTION provided by applicant The timely diagnosis and optimal management of hemostatic dysfunction in trauma and surgical patients is challenging due to the unavailability of suitable analytical tools The current need to conduct multiple tests with multiple blood samples on multiple devices to ascertain the specific nature of the hemostatic defect by examining the different platelet aggr ...