Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. A Noninvasive Platform to Assess Maternal Risk for Perinatal Complications in the First Trimester

    SBC: Cradle Genomics, Inc.            Topic: NICHD

    Limited information is available about early human placentation when many pregnancy pathologies originateTo address this knowledge gap and begin development of robust diagnostic tool to manage pregnancy complicationswe propose a pilot study based on a highly sensitive immune assay and our company s base technologyTrophoblast Retrieval and Isolation from the CervixTRICTRIC uses a Pap smearconsidere ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. A therapeutic approach for potential prevention of aromatase inhibitor-induced bone loss

    SBC: NANOMEDIC, INC.            Topic: NIA

    AbstractIn this SBIR Phase I applicationour goal is to demonstrate proof of concept of our lead chelating agent as a potential therapeutic for the prevention of osteoporosis induced by aromatase inhibitorAItherapy in postmenopausal women with hormone receptor positive breast cancerAlthough AI therapy shows great improvements in cancer free and overall survivalits treated patients face a risk of os ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Daily and localized NSAID sonophoresis for symptomatic treatment of knee osteoarthritis

    SBC: ZETROZ SYSTEMS, LLC            Topic: NIA

    Project SummaryOsteoarthritisOAis the most common type of arthritisaffecting overmillion adults in the United States inand represents overof medical office visits according to the Centers for Disease Control and Prevention and the National Institutes of HealthOverof individuals overhave symptomatic OA and reduced mobility due to the diseaseOA pain is often mitigated with conservative treatment app ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Visible light activated implant devices to prevent biofilm formation

    SBC: Sonata LLC            Topic: NCEZID

    Prevention of biofilms on invasive medical devices has the potential to significantly reduce hospital acquired infections and improve patient outcomesProsthetic joint infectionsPJIsacquired from orthopedic implantsoften the result of microorganism contamination on the implant surface during surgeryaffect patient recoveries and can lead to significant mortalitiesOne approach for reducing the incide ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Establishing the POROS Intracellular Delivery System as a Platform for Cellular Therapeutics

    SBC: OPENCELL TECHNOLOGIES, INC.            Topic: 100

    Abstract SignificanceIntracellular delivery of nucleic acids to immune cells is an important component of many current and anticipated cellular therapiesincluding chimeric antigen receptor T CellCAR Ttherapies for the treatment of cancerThese therapies use immune cells called T cellseither from the patient themselvesor a healthy donorand genetically engineer them to kill the tumor cellsThe genetic ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Single-cell Phosphoprotein Assay to Evaluate Brain Tumor Therapeutic Resistance

    SBC: IsoPlexis            Topic: 102

    Although signal transduction inhibitors occasionally offer clinical benefit for cancer patientssignal flux emanating from oncogenes is often distributed through multiple pathwayspotentially underlying the resistance which causes failure of most such inhibitorsMeasuring signal flux through multiple pathwaysin response to signal transduction inhibitorsmay help uncover network interactions that contr ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Use of Stem Cells to Enhance and Extend Continuous Glucose Monitoring in Vivo

    SBC: Cell And Molecular Tissue Engineering LLC            Topic: 200

    Implantable glucose sensor based monitoring of blood glucose levels in diabetic patients has been available for overyearsHoweverdespite improvements to sensor functionalityrecalibration of the sensor device is often a necessity in order to compensate for unreliable sensor performanceThe development of highly accurate and long lived implantable sensors is critical to the development of theartificia ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Development of an a MC1R selective companion diagnostic imaging probe

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    The melanocortinreceptorMC Ris over expressed on uveal and cutaneous melanoma cellsbut notin healthy normal tissuesWe have developed a proprietary ligandMTIthat binds to MC R inmelanoma cells with high affinity and specificityThrough our SBIR Phase I contractwedemonstrated that MC R targetedAc DOTA MTIlacks of overt toxicity at single doses thatproduce significant efficacy against uveal and cutane ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Demonstrating the feasibility of CCG-257081 as a preventive therapy to inhibit bleomycin-induced lung fibrosis in mice

    SBC: FIBROSIX INC.            Topic: 102

    ABSTRACT Front line therapy for patients diagnosed with Hodgkin s lymphoma or germ cell cancers includes the drug bleomycina highly effective agent with a debilitating side effectAboutof bleomycin treated patients develop pneumonitis with progression to pulmonary fibrosis during therapy as a direct result of bleomycinAn estimatedof these cases are fatalThe current standard approach to this problem ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. 1-D Titania Nanostructure Based Wearable Alcohol Sensor with Tunable Sensitivity and Artificial Intelligence

    SBC: NanoSynth Materials and Sensors Inc.            Topic: 450

    PROJECT SUMMARY The overarching goal of this proposal is to develop an artificially intelligent alcohol sensor that is wearablenoninvasivesmartand aestheticThe aimin Phase Iis to design and develop the alcohol sensor based on metali eCobaltfunctionalized Titanium nanotubesTiNTto detectmonitorand display blood alcohol levels in real time using microcontrollers based wrist band like devicesAt the co ...

    SBIR Phase I 2018 Department of Health and Human Services
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