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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A Noninvasive Platform to Assess Maternal Risk for Perinatal Complications in the First Trimester

    SBC: Cradle Genomics, Inc.            Topic: NICHD

    Limited information is available about early human placentation when many pregnancy pathologies originateTo address this knowledge gap and begin development of robust diagnostic tool to manage pregnancy complicationswe propose a pilot study based on a highly sensitive immune assay and our company s base technologyTrophoblast Retrieval and Isolation from the CervixTRICTRIC uses a Pap smearconsidere ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. A Diet Tracking, Monitoring and Optimization mHealth Tool for Patients with Inborn Errors of Metabolism

    SBC: BRIGHTOUTCOME INC.            Topic: NICHD

    Inborn errors of metabolismIEMare a group of rare geneticinheriteddisorders that cause a block in a metabolic pathway leading to clinically significant consequencescausing developmental and intellectual disabilitiesseizuresandif untreatedcoma and deathThe majority of the IEM disorders are managed by manipulation and modification of diet alone to reduce toxic metabolitesor with a combination of die ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Soft-Focused HIFU Treatment of Common Peroneal Nerve Injury

    SBC: ACOUSTIC MEDSYSTEMS, INC.            Topic: 105

    ABSTRACT The economic burden of chronic pain in the U Sis staggeringIn the cases of medically refractory chronic neuropathic painneuromodulationsuch as spinal cord stimulationSCSand or dorsal root ganglionDRGstimulationis a non opioid based optionThough neuromodulation is typically electricalhere we examine an alternative with pulsed high intensity focused ultrasoundHIFUDelivering HIFU at lower do ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. A therapeutic approach for potential prevention of aromatase inhibitor-induced bone loss

    SBC: NANOMEDIC INC            Topic: NIA

    AbstractIn this SBIR Phase I applicationour goal is to demonstrate proof of concept of our lead chelating agent as a potential therapeutic for the prevention of osteoporosis induced by aromatase inhibitorAItherapy in postmenopausal women with hormone receptor positive breast cancerAlthough AI therapy shows great improvements in cancer free and overall survivalits treated patients face a risk of os ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. A wearable sensor system for hand hygiene compliance tracking

    SBC: Microsensor Labs, LLC            Topic: R

    Project Summary This Small Business Innovation Research Fast Track project aims to develop a wearable sensor system for hand hygiene compliance tracking and validate its efficacy through a pilot trial in clinical settingsHealthcareAssociated InfectionsHAIsare the most common type of complication for patients who are hospitalizedAccording to the Center for Disease Control and Preventioninthere were ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Multi-modal machine learning detection and tracking of traumatic brain injury neurodegeneration and its differentiation from Alzheimer's disease

    SBC: Adm Diagnostics, Inc.            Topic: NIA

    SUMMARY The proposed research focuses on the use of neuroimaging and machine learning to detect and understand the progression of neurodegeneration caused by repetitive brain traumaand to differentiate this from that caused by Alzheimer s diseaseADand other dementiasThe deliverables defined in this Phase I stage will support the development of a commercial software product for use in pharmaceutica ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Daily and localized NSAID sonophoresis for symptomatic treatment of knee osteoarthritis

    SBC: Zetroz Systems LLC            Topic: NIA

    Project SummaryOsteoarthritisOAis the most common type of arthritisaffecting overmillion adults in the United States inand represents overof medical office visits according to the Centers for Disease Control and Prevention and the National Institutes of HealthOverof individuals overhave symptomatic OA and reduced mobility due to the diseaseOA pain is often mitigated with conservative treatment app ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Development of Nasal IGF-1 as a Migraine Therapeutic

    SBC: Seurat Therapeutics, Inc.            Topic: 105

    Summary AbstractMigraine is an immense healthcare burdenExisting therapeutics are only fractionally effective since they may not adequately target underlying key causesCNS hyperexcitabilityHEand oxidative stressOSBrain HE enhances OS and OS in turn promotes brain HEincluding that seen in the trigeminal systemTSa site involved in migraine painUnraveling this vicious cycle may lead to novel therapeu ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Establishing the POROS Intracellular Delivery System as a Platform for Cellular Therapeutics

    SBC: OPENCELL TECHNOLOGIES, INC.            Topic: 100

    Abstract SignificanceIntracellular delivery of nucleic acids to immune cells is an important component of many current and anticipated cellular therapiesincluding chimeric antigen receptor T CellCAR Ttherapies for the treatment of cancerThese therapies use immune cells called T cellseither from the patient themselvesor a healthy donorand genetically engineer them to kill the tumor cellsThe genetic ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Single-cell Phosphoprotein Assay to Evaluate Brain Tumor Therapeutic Resistance

    SBC: ISOPLEXIS CORPORATION            Topic: 102

    Although signal transduction inhibitors occasionally offer clinical benefit for cancer patientssignal flux emanating from oncogenes is often distributed through multiple pathwayspotentially underlying the resistance which causes failure of most such inhibitorsMeasuring signal flux through multiple pathwaysin response to signal transduction inhibitorsmay help uncover network interactions that contr ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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