Award Data

ABSTRACT Thetis plans to investigate TP an innovative and potential first in class therapeutic agent as an oral therapy for the induction and maintenance of remission of intestinal inflammation symptoms in ulcerative colitis UC patients While the precise etiology of UC is unknown it is thought to result from an inappropriate inflammatory response to commensal gut bacteria in genetically ...

PROJECT SUMMARY ABSTRACT nView medicalSurgical inaccuracies impact patient safety and increase healthcare costsSpinal fusions are a prime examplewithprocedures per year in the US it is the sixth most frequent procedure and reoperation rates areThereareanestimatedrevisionsurgeriesduetomisplacedscrewsthatcouldbeavoidedifintraoperativeD guidance was standardThe total cost of the revision surgeries du ...

Project Summary Keratoconus KCN is a progressive disorder associated with structural changes in corneal collagen organization that leads to corneal thinning and ruptures in Bowman s layer and or Descemet s membrane As the disease progresses it leads to irregular astigmatism progressive myopia and subsequently poor visual acuity Treatment options are surprisingly limited with no oral or topi ...

ABSTRACT Modulation Therapeutics is developing a first in class cyclic peptide coined MTI for the treatment of multiple myeloma The company currently has a license for the parent molecule which has been awarded a patent covering the intellectual property for both composition of matter and use in cancer in the US and Europe Modulation Therapeutics is now poised to further advance this class ...

Checkpoint inhibitor CPI therapy has transformed treatment of solid tumors Clinical responses in the range of with prolonged survival have been reported for tumors such as malignant melanoma and non small cell lung cancer that previously had poor response rates and dismal prognoses Current therapies block PD PD L and CTLA and there are other targets being developed such as LA ...

PROJECT SUMMARY The cell surface CD protein is a marker of self and signals through its receptor signal regulatory protein SIRP expressed by macrophages to transmit an anti phagocytic donandapos t eat me signal CD is expressed by virtually all cell types is overexpressed by cancer cells as a mechanism to avoid immune surveillance and phagocytosis and is a negative prognostic f ...

PROJECT SUMMARY ABSTRACT No longer than lines of text Atrial Fibrillation AF is the most common sustained dysrhythmia worldwide Although new AF treatment strategies have emerged over the last decade a major challenge facing clinicians and researchers is the paroxysmal often short lived and frequently asymptomatic nature of AF Paroxysmal and asymptomatic AF would be found i ...

Whenever premature birth interrupts normal retinal vascularization of the developing eye retinopathy of prematurity ROP can occur When ROP was first reported in the s it was associated with high oxygen delivery to preterm infants Though oxygen delivery to preterm infants is now carefully regulated ROP is still a common occurrence In very low birthweight infants birth weights andlt ...

Project Summary Identifying disease causing genetic variants is a complex process often involving the analysis of the genomes of affected patients and their immediate families When employing these state of the art techniques however the number of patients receiving a successful diagnosis is still only at approximately One reason for this low diagnosis rate is the presence of localised dat ...

Abstract Sepsis is a major public health concern and the primary cause of death in the intensive care unit accounting for more than $ billion of total US hospital costs in Sepsis can lead to a life threatening drop in blood pressure termed septic shock which can quickly lead to the failure of vital organs such as lungs kidneys and liver and eventually to death Nearly all sepsi ...