Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Development of Small Molecules MAP3K2/3 Inhibitor for Treatment of Acute Lung Injury

    SBC: QX Therapeutics, Inc.            Topic: NHLBI

    Project Summary Abstract Acute lung injuryALIor Acute Respiratory Acute Respiratory Distress SyndromeARDSare characterized by an increased permeability of the alveolar capillary barrier resulting in lung edema with protein rich fluidthus resulting in impairment of arterial oxygenationLung edemaendothelial and epithelial injury are accompanied by an influx of neutrophils into the interstitium and b ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Implantable Peripheral Nerve Stimulator for Treatment of Phantom Limb Pain

    SBC: RIPPLE, LLC            Topic: 999

    Abstract Chronic phantom limb painPLPhas been reported to inflict as many asof people with amputationsPLP is described as feeling like burningtwistingitchingor pressure in part of the missing limbThese painful sensations have a substantial negative impact on quality of lifepeople who suffer PLP have high rates of depressiondifficulty sleepingregular absences from workdissociation with family frien ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Development and Validation of Novel Coatings that Extend Glucose Sensor Accuracy and Lifespan in vivo

    SBC: Cell And Molecular Tissue Engineering LLC            Topic: NIDDK

    An overarching factor in the development of any successfulartificial pancreassystem is the advancement of a highly accurate and long lived glucose sensorwithout the need for numerous recalibrationsFrequentlyimplantable glucose sensors demonstrate insufficient reliability with respect to performanceaccuracy and response timewhich is thought to be the result of poor biocompatibilityCentral to these ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Fast and Easy Assessment of Stroke

    SBC: ALVA HEALTH INC            Topic: 108

    PROJECT SUMMARY The goal of this study is to develop an objective tool for the fast and easy assessment of strokeby developing a novel analytics platform that quickly identifies potential stroke from movement signatures captured with wearable sensorsThe tool uses unobtrusive wearable sensors and does not require medical training to operateand thus will be valuable for families and caregivers of ol ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. ANTIMICROBIAL TECHNOLOGY TO ACTIVELY MITIGATE EAR TUBE INFECTIONS LONG TERM

    SBC: Thrombodyne Inc            Topic: NIDCD

    ABSTRACTOtitis media or middle ear infections is a prevalent disease associated with early childhoodThe primary surgical intervention for persistent and recurring otitis media is insertion of ear tubestympanostomymyringotomy tubesThere are aboutear tubes placed annually in the United StatesA recognized risk with ear tubes is secondary infection or post operative otorrheaThe rate of secondary infec ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Extended Nitric Oxide Delivery Device to Reduce/Prevent Tunneled Dialysis Catheter Infections

    SBC: NOTA Laboratories LLC            Topic: 400

    ABSTRACT Nitric oxideNOplays a critical role in a wide range of bodily functionsincluding vasodilationneurotransmissionwound healingsuppression of platelet activationand modulation of ciliary beat frequencyFurtherinhaled gas phase NO is now routinely used to treat neonatal pulmonary hypertensionIn infectionNO released by neutrophils and macrophages functions as a potent antimicrobial antiviral age ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Development of the High Throughput APT-SNAP Platform for Rapid Identification ofNuclease-Resistant RNA Aptamers against p53 Missense Mutations

    SBC: Proteovista LLC            Topic: 102

    Project Summary Development of the High Throughput APT SNAP Platform for Rapid Identificationof Nuclease Resistant RNA Aptamers against pMissense MutationsPIsChristopher LWarren and Mary SOzers Normal proteins are often mutated in cancergenerating dominant negative effects as well as gain of function activity that contribute to cancer development and to the inhibition of therapeutic responsesProte ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Age-dependent Single-cell Metabolomic and Proteomic Profiling of Human Immune System

    SBC: IsoPlexis            Topic: NIA

    With this phase I submissionIsoPlexis proposes to deliver comprehensive profiling of the immune system as a measure of age dependent health in response to medical challenges or traumaThis assay will connect signaling events in the metabolome and proteome from thousands of single cells in parallel enabling the simultaneous tracking of metabolic activity and protein signaling within each immune cell ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A fast, scalable, cost-effective, single-stranded library protocol for cell-free DNA

    SBC: Claret Bioscience LLC            Topic: 102

    Project Summary Liquid biopsy is a potentially powerfulnon invasive approach for detectingclassifying and monitoring tumors by capturing cell free DNA molecules found circulating in blood and other bodily fluidsAny next generation sequencingNGSbased approach requires an efficient protocol for converting cell free DNA into a sequencing libraryNearly all currently available NGS library preparation m ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. A Next-Generation, Efficient, Fully Automated, High-Definition 3D Patient Treatment Verification System for Stereotactic Radiation Therapy,Radiosurgery and Particle Therapy

    SBC: MGS RESEARCH INCORPORATED            Topic: 101

    The GoalTo improve patient safety and outcomes for all modalities of external beam radiation therapy in a cost effective manner by using a new type of HDD pre treatment Patient Specific Quality AssurancePSQAProduct to be Developed by the end of Phase IIThe CrystalBallSystemwill consist of a fully robotized fast laser CT of low cost reusable radiochromic polymer gel dosimetersIt will detect and cor ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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