Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. PalmStat: a self-contained point of care diagnostic platform

    SBC: Synectic Engineering, Inc            Topic: NIAID

    DESCRIPTION (provided by applicant): Point of care testing is a test that is performed near or at the site of care. In addition it has come to imply a rapid turnaround time, ease of use and convenience for the patient. Traditional Point of Care single usecartridge tests are lateral flow immunoassay tests where the capture antibody is labeled with a chromagen, which allows for a positive reaction t ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. Novel Antibacterial Scaffold from Natural Products

    SBC: LIFEPHARMS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Despite the rise of bacterial resistance to antibiotics, the development of new antibiotics is on the decline. Methicillin-resistant Staphococcal aureus infections (MRSA) in the United States has been increasing, causing 19,000 deaths per year in the United States and contributing to 3 billion to 4 billion of additional annual health care costs. The issue of ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. Apparatus and Method for Convection Enhanced Therapeutic Delivery

    SBC: FHC, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Malignancies of the brain are among the most devastating diseases known. Glioblastoma multiform (GBM) in particular are known for their rapid, uncontrolled, and aggressive growth. Very little progress has been made in the treatment of GBM over the past 25 years. A more recent promising therapeutic approach is convection enhanced delivery (CED) in which chemothe ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. Novel Glycosaminoglycan Ethers for Prevention of Metastasis

    SBC: GLYCOMIRA, LLC            Topic: NCI

    DESCRIPTION (provided by applicant): Heparin and its derivatives block P- and L-selectin mediated metastatic spread of cancer in animal models, and they potently inhibit the matrix degrading enzyme heparanase. Moreover, several large clinical trials performed with heparin or low molecular weight heparin have shown that survival is significantly improved by daily subcutaneous administration of hepa ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. Screening of FoxA1-ER-DNA disruptors for development of breast cancer therapeutic

    SBC: Proteovista LLC            Topic: NCI

    DESCRIPTION (provided by applicant): Estrogen receptor a (ERa) is the major therapeutic target for breast cancer, and ERa binding at target genes in breast cancer cells is guided by DNA binding pioneer factor proteins such as FoxA1. Although tamoxifen is asuccessful therapeutic for suppressing ER-mediated gene regulation, resistance to tamoxifen occurs in most breast cancer patients within five ye ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. High Throughput Method to Assess SNP Functionality in Prostate Cancer

    SBC: Proteovista LLC            Topic: NCI

    DESCRIPTION (provided by applicant): A critical unmet need in implementing personalized medicine is the ability to sort through the millions of single nucleotide polymorphisms (SNPs) present in the human genome and to pinpoint which of these DNA variations are causative in disease. A key under-studied function of SNPs is their ability to generate or disrupt genomic binding sites for transcription ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. Unique Opioid Analgesics With No Addiction Liability or Dysphoria

    SBC: PHOENIX PHARMALABS, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): This Phase I application requests funds to support the continued preclinical evaluation of a novel opioid analgesic, PPL-103, and the synthesis and initial preclinical evaluation of a series of new analogs thereof.PPL-103, a potent analgesic, has undergone early preclinical studies by Phoenix PharmaLabs, Inc. (PPL), the applicant organization, and NIDA. PPL ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis

    SBC: GLYCOMIRA, LLC            Topic: NIDCR

    DESCRIPTION (provided by applicant): Chronic gingival inflammation afflicts over half of all American adults and can progress to periodontal disease, eventually resulting in tooth loss. Periodontitis is initiated by bacterial infection of the gingival tissues through a subgingival microbial biofilm on the tooth surface that releases bacterial lipopolysaccharide (LPS) and other antigens. In turn, L ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. Novel Glycosaminoglycan Derivatives for Treatment of Bladder Inflammation

    SBC: GLYCOMIRA, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Painful bladder syndrome/interstitial cystitis (PBS/IC) is an indolent bladder disorder that has continued to be a debilitating disease with few truly effective treatment options. Inflammatory conditions that afflict the urinary bladder can lead to pelvic pain, debilitating urinary symptoms, bladder fibrosis, recurring urinary infection, and renal failure. We h ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Targeted photoacoustic imaging of VEGF receptors in angiogenic vasculature

    SBC: SIBTECH, INC.            Topic: NIBIB

    DESCRIPTION (provided by applicant): We propose to develop a contrast agent for photoacoustic imaging targeted to the receptors of vascular endothelial growth factor (VEGFR), so it can be accumulated and retained in tumor endothelial cells by VEGFR-mediated endocytosis. VEGFR are over expressed in angiogenic tumor vasculature from the very early stages of tumor development and therefore VEGFR imag ...

    SBIR Phase I 2011 Department of Health and Human Services
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