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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Demonstrating the feasibility of CCG-257081 as a preventive therapy to inhibit bleomycin-induced lung fibrosis in mice

    SBC: FIBROSIX INC.            Topic: 102

    ABSTRACT Front-line therapy for patients diagnosed with Hodgkin’s lymphoma or germ cell cancers includes the drug bleomycin, a highly effective agent with a debilitating side effect. About 10-12% of bleomycin-treated patients develop pneumonitis with progression to pulmonary fibrosis during therapy as a direct result of bleomycin. An estimated 10-20% of these cases are fatal. The current standar ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Oral/Topical D-peptide TNF Inhibitors for Inflammatory Bowel Disease

    SBC: NAVIGEN, INC.            Topic: 300

    Project SummaryInflammatory bowel diseaseIBDaffects millions worldwideIBD can be divided into Crohn s DiseaseCDand Ulcerative ColitisUCboth of which are characterized by chronic inflammation in the gutleading to diarrheaulcerationbleedingand in many cases tumorsCurrentlymild to moderate IBD is treated orally with aminosalicylatesASAwhile more severe cases require the use of systemic immunosuppress ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Introducing Neuroscience and Neurocomputation Concepts to High School Students using Brain-based Neurorobots

    SBC: BACKYARD BRAINS INCORPORATED            Topic: 101

    PROJECT SUMMARY Understanding the brain is a profound and fascinating challengecaptivating the scientific community and the public alikeThe lack of effective treatment for most brain disorders makes the training of the next generation of neuroscientistsengineers and physicians a key concernHowevermuch neuroscience is perceived to be too difficult to be taught in schoolTo make neuroscience more acc ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Daily and localized NSAID sonophoresis for symptomatic treatment of knee osteoarthritis

    SBC: Zetroz Systems LLC            Topic: NIA

    Project SummaryOsteoarthritisOAis the most common type of arthritisaffecting overmillion adults in the United States inand represents overof medical office visits according to the Centers for Disease Control and Prevention and the National Institutes of HealthOverof individuals overhave symptomatic OA and reduced mobility due to the diseaseOA pain is often mitigated with conservative treatment app ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Therapeutic Inhibition of MIF to Improve Glucocorticoid Response

    SBC: L2 Diagnostics, LLC            Topic: NIAID

    Abstract Despite the advent of biological therapiesglucocorticoidsGCsremain the most widely prescribed medicines for the management of inflammatory diseases such as lupusasthmamultiple sclerosisand rheumatoid arthritisHoweverlong term and high dose GC use is inevitably accompanied by systemic toxicityThere are no adjunctive therapies that could enhance the disease modifying effects of GCs at low d ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. A Noninvasive Prenatal Testing Platform for Aneuploidy at Five Weeks of Gestation

    SBC: Cradle Genomics, Inc.            Topic: NICHD

    The overall goal of this research is to provide a flexible prenatal genetic testing kit that can be expanded to detectany inheritable trait as early asand up toweeks of gestationfrom a safenoninvasive Pap smearStudiesshow that perinatal Pap tests pose no risk to mother or fetusand capture trophoblastlike cells that migrate fromtheplacentaintothereproductivetractTrophoblastretrievalandisolationfrom ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Shoe insert to measure axial and shear forces as well as temperature at 42 locations in the insert and send data by wireless transmission to a PC, smart phone or other wireless devices.

    SBC: RTC Electronics Inc            Topic: 200

    PROJECT SUMMARY ABSTRACT Diabetic foot ulcers are extremely costly and debilitatingThe cost of care doubles in patients with diabetic foot ulcers compared to patients without ulcersEven if an ulcer healsthere is arisk there will be a recurrence within one yearso the problem is not likely to go away once it has startedThe presence of ulcers and the potential necessity of an amputation both lead to ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Rapid and Efficient Extraction of Bacteria from Whole Blood for Sepsis Diagnosis

    SBC: PRECISION MEMBRANES, LLC            Topic: NIAID

    AbstractPrecision MembranesOverpeople died inin the U Salone due to septicemiaa blood stream infection capable of eliciting the life threatening condition known as sepsisRapid identification and effective treatment of septicemia are essential to prevent severe sepsis and overcome the alarming mortality rates observed todayCurrent diagnostics require a minimumhour blood culture prior to final ident ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. An antigen-detection assay to diagnose Babesia microti infection

    SBC: L2 Diagnostics, LLC            Topic: NIAID

    Project Summary Human babesiosis is a malaria like multisystem disease caused primarily by Babesia microtian emerging apicomplexan parasite that infects and develops within human erythrocytesThe parasite is transmitted to humans by the tick vector Ixodes scapularis and can also be introduced through blood transfusionInfection can cause flu like symptomsand severe infection can be fatalin particula ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Targeting Exonuclease Resistant RNA to Develop Zika Virus Therapeutics

    SBC: Nymirum, Inc.            Topic: NIAID

    Project Summary Abstract Outbreaks of Zika VirusZIKVhave been recorded in Africathe AmericasAsiaand the Pacificand despite significant resources being dedicated to combat ZIKV proliferationthere is no known cureMany mosquitoborne flavivirus such as ZIKVDengue virusYellow Fever virusand West Nile virus have structuredUTRsStructured RNA elements in theUTRs allow the virus to resist degradation by ho ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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