Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Development of Nanvas TM (Oil in Water Nanoemulsion Adjuvant) Formulated Allergens as Intranasal Immunotherapeutic Vaccines for Peanut Allergy

    SBC: Bluewillow Biologics, Inc.            Topic: NIAID

    Food allergy is an emerging health problem with increasing incidence and severityparticularly in childrenand continuing throughout adulthoodSincethe incidence of self reported peanut allergy has risen significantly representing a mounting financial burden to the healthcare systemWith no approved therapeutics availablevarious forms of immunotherapy have been evaluated but generally do not facilitat ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Nano-emulsion Immuno-suppressive Adjuvant for Allergy Vaccines

    SBC: Epitogenesis, Inc.            Topic: NIAID

    Bronchial asthma is a chronic respiratory disease that can be lethalAsthma is a global health problemAccording to the CDCin USAthere are currentlymillion asthma sufferers and this number is increasingHalf of the asthma patients have at least one hospitalization per yearwith an annual medical cost of $BTraditionallyasthma is treated during flare ups with prescribed inhaled corticosteriodsIn recent ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. TOPIC 394- A VERSATILE RADIATION-TRIGGERED PHOSPHOR PLATFORM FOR LOCALIZED ANTI-CANCER THERAPY

    SBC: PACT & HEALTH LLC            Topic: NCI

    The goal of this project is to fabricate a novel nanoscintillator photosensitizer complex for X ray excited photodynamic therapyXPDTHereina low dose of X raysltGyis used to excite scintillating nanoparticleswhich downconvert ionizing radiation to UV vis lightPhotosensitizers loaded onto the nanoscintillator complex absorb this UV vis emission and generate cytotoxic reactive oxygen speciesROSin the ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development and evaluation of an all-in-one integrated webbased buprenorphine treatment program for opioid use disorder (Digital Interventions for Opioid Disorders- DIOD)

    SBC: WORKIT HEALTH, INC.            Topic: NIDA

    Workit Health will develop an automated system that helps clinicians organize and analyze patient dataPatients will express higher rates of treatment adherence in Medication Assisted Treatment in conjunction with psychosocial supportWorkit Health will conduct a randomized clinical trial that combines psychosocial support through CBT modules and peercounselor support and the DIOD program which adds ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. RAE (Realize, Analyze, Engage)- A Digital Biomarker Based Detection and Intervention System for Stress and Craving During Recovery from Substance Abuse Disorders

    SBC: CONTINUEYOU, LLC            Topic: NIDA

    PROJECT SUMMARY The research project outlined in this SBIR submission will develop the RealizeAnalyzeEngageRAEplatform into a tool to promote sustained recovery in individuals receiving treatment for substance use disorderIn this proposalthe investigators intend to deploy the RAE systemconsisting of a wearable sensora smartphone appand a clinical portalto provide individuals in recovery and their ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A novel vaccine against mosquito-borne Zika virus based on mosquito salivary gland protein AgBR1

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    PROJECT SUMMARYZika virusan emerging flavivirusis associated with severe clinical outcomesincluding Guillain Barrsyndrome and birth defectsTransmission of Zika virus is primarily mosquitoborneMosquito salivary proteins are known to enhance infectivity and pathogenesis in Zikadengue and West Nile viruses by modulating immune responsesThis proposal seeks to develop a novel vaccine against Zika virus ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Small Molecule Apelin Receptor agonists for teh treatment of Heart Failure in PAH

    SBC: VASCUMAB LLC            Topic: NHLBI

    SUMMARY The apelin receptorAPLNRagonist program project is seeking to discover an orally active small molecule drug to preserve and improve the heart s right ventricularRVfunction in patients suffering from pulmonary arterial hypertensionPAHa devastating disease with high morbidity and mortalityThere is compelling evidence that RV function is a major determinant of clinical outcomes in PAH patient ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. New instrument and methods for fast, diagnostic-quality histology of un-embedded bone marrow and lymph node specimens

    SBC: Applikate Technologies LLC            Topic: 102

    Project Summary Overbone marrow biopsies are performed every year in the United Stateswhile hundreds of thousands more lymph node biospies are performedHistological evaluation of these biopsies is a critical component of care for hematologic diseases including leukemialymphomamyelodysplastic syndromemyeloproliferative disease and non neoplastic conditions such as viral infections and autoimmune co ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Preclinical development of a first in class therapeutic for treatingidiopathic pulmonary fibrosis

    SBC: MDI THERAPEUTICS, INC            Topic: NHLBI

    Abstract Fibrosis is a common end stage pathologic outcome of many diseases that is characterized by excessive accumulation of extracellular matrix proteinsloss of tissue homeostasisand ultimately organ failurePulmonary fibrosis can be particularly devastatingand is associated with significant morbidity and an overall poor survivalDisorders such as idiopathic pulmonary fibrosisIPFlead to a progres ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Analytics-Based Platform for Diabetic Retinopathy Care Management

    SBC: Retinal Care Inc.            Topic: NEI

    ABSTRACT Despite the overefficacy of diabetic retinopathyDRtreatmentit continues to be the leading cause of blindness in working age AmericansOvermillion adults in the US have diabetesOf thesewill develop DR andwill develop vision threatening DRVTDRCurrentlyless than half of all patients with diabetes receive the recommended annual dilated eye exam andof those diagnosed with VTDRonlyundergo timely ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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