Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A novel biodegradable nerve conduit drug delivery device for peripheral nerverepair

    SBC: Microsurgical Innovations Inc            Topic: 999

    Project Summary Nerve injury can occur due to traumachronic compression or disease processes such as diabetes or tumors and have a tremendous socioeconomic impact from loss of work and healthcare costsThere is still a clinical need to improve recovery from nerve injuriesand a new nerve conduit drug delivery device that addresses this clinical need is the focus of the present proposalOur group has ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Implantable Peripheral Nerve Stimulator for Treatment of Phantom Limb Pain

    SBC: RIPPLE, LLC            Topic: 999

    Abstract Chronic phantom limb painPLPhas been reported to inflict as many asof people with amputationsPLP is described as feeling like burningtwistingitchingor pressure in part of the missing limbThese painful sensations have a substantial negative impact on quality of lifepeople who suffer PLP have high rates of depressiondifficulty sleepingregular absences from workdissociation with family frien ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Development of Small Molecules MAP3K2/3 Inhibitor for Treatment of Acute Lung Injury

    SBC: QX Therapeutics, Inc.            Topic: NHLBI

    Project Summary Abstract Acute lung injuryALIor Acute Respiratory Acute Respiratory Distress SyndromeARDSare characterized by an increased permeability of the alveolar capillary barrier resulting in lung edema with protein rich fluidthus resulting in impairment of arterial oxygenationLung edemaendothelial and epithelial injury are accompanied by an influx of neutrophils into the interstitium and b ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Stabilization of the Alveolar-Capillary Barrier with ARF6 Inhibitor as a Treatment for Severe Influenza

    SBC: NAVIGEN, INC.            Topic: NHLBI

    SUMMARYInfluenzavirusinfectionisoneofthemostcommonacuterespiratorydiseasesandremainsoneofthelargestdiseaseburdensonhumanswithsevereprimaryviralpneumoniaoftenresultingindeathThepathogenicityofinfluenzaincludesahostresponsethatcanincludeaseveresystemicinflammatoryreactioncytokinestormandensuingvascularleakVascularleakisafundamentalelementinthepathogenesisofcirculatoryshockandmultipleorganfailurewhic ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Development and Validation of Novel Coatings that Extend Glucose Sensor Accuracy and Lifespan in vivo

    SBC: Cell And Molecular Tissue Engineering LLC            Topic: NIDDK

    An overarching factor in the development of any successfulartificial pancreassystem is the advancement of a highly accurate and long lived glucose sensorwithout the need for numerous recalibrationsFrequentlyimplantable glucose sensors demonstrate insufficient reliability with respect to performanceaccuracy and response timewhich is thought to be the result of poor biocompatibilityCentral to these ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Fast and Easy Assessment of Stroke

    SBC: ALVA HEALTH INC            Topic: 108

    PROJECT SUMMARY The goal of this study is to develop an objective tool for the fast and easy assessment of strokeby developing a novel analytics platform that quickly identifies potential stroke from movement signatures captured with wearable sensorsThe tool uses unobtrusive wearable sensors and does not require medical training to operateand thus will be valuable for families and caregivers of ol ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A Next-Generation, Efficient, Fully Automated, High-Definition 3D Patient Treatment Verification System for Stereotactic Radiation Therapy,Radiosurgery and Particle Therapy

    SBC: MGS RESEARCH INCORPORATED            Topic: 101

    The GoalTo improve patient safety and outcomes for all modalities of external beam radiation therapy in a cost effective manner by using a new type of HDD pre treatment Patient Specific Quality AssurancePSQAProduct to be Developed by the end of Phase IIThe CrystalBallSystemwill consist of a fully robotized fast laser CT of low cost reusable radiochromic polymer gel dosimetersIt will detect and cor ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Low Cost Electrochemical Gas Phase Nitric Oxide Generator for Biomedical Applications

    SBC: NOTA Laboratories LLC            Topic: NHLBI

    ABSTRACTTherapeutic use of gas phase nitric oxideNOhas several important applications in medicineSince its first medical application more thanyears agoinhaled nitric oxideINOhas become a mainstay of intensive care for lung failure patientsAs a pulmonary vasodilatorINO is essential in neonatologylung transplantationand pulmonary hypertensionAs an inhaled antiseptic agentNO has been proposed in the ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A fast, scalable, cost-effective, single-stranded library protocol for cell-free DNA

    SBC: Claret Bioscience LLC            Topic: 102

    Project Summary Liquid biopsy is a potentially powerfulnon invasive approach for detectingclassifying and monitoring tumors by capturing cell free DNA molecules found circulating in blood and other bodily fluidsAny next generation sequencingNGSbased approach requires an efficient protocol for converting cell free DNA into a sequencing libraryNearly all currently available NGS library preparation m ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Additive Manufactured PEKK Implants for Small Bone Arthroplasty

    SBC: Oxford Performance Materials, Inc.            Topic: NIAMS

    ABSTRACT This Phase I STTR is designed to evaluate the feasibility of using the OsteoFabtechnology platform for joint arthroplastyArthroFabdevicesspecifically targeting replacement of the small carpal bones in the wrist and hemiarthroplastyOsteoFabtechnology is the combination of Oxford Performance Materialsandaposproprietary formulation of polyetherketoneketoneOXPEKKpolymerand additive manufactur ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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