Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. NarcoBond: Opioid Targeted Biomimetic Nanosponges for Treatment of Opioid Overdose

    SBC: CiBots            Topic: NIDA

    Abstract We propose to develop a broad acute sub acute opioid drug detoxifying treatment for opioid overdose that can complement andampcompensate for the deficiencies in nalaxoneusing opioid targeted biomimeticnanospongesthat absorb overdosed opioids in the bodyNoteif this proof of concept is successful herethe approach may be tailored to other drugs of abuseCalledNarcoBondTMthesenm diameter nanos ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Development of Small Molecules MAP3K2/3 Inhibitor for Treatment of Acute Lung Injury

    SBC: QX Therapeutics, Inc.            Topic: NHLBI

    Project Summary Abstract Acute lung injuryALIor Acute Respiratory Acute Respiratory Distress SyndromeARDSare characterized by an increased permeability of the alveolar capillary barrier resulting in lung edema with protein rich fluidthus resulting in impairment of arterial oxygenationLung edemaendothelial and epithelial injury are accompanied by an influx of neutrophils into the interstitium and b ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Therapeutic antibodies for treating chemotherapy induced peripheral neuropathic pain

    SBC: Abalone Bio, Inc.            Topic: 102

    SummaryTherapeutic antibodies for treating chemotherapy induced peripheral neuropathic pain Chroniclife disrupting painsuch as allodynia from chemotherapy induced peripheral neuropathyCIPNis difficult to manageIn this Phase I SBIRAbalone Bio proposes to develop a first in class specific CBagonist antibody that is BOTH an effective and safe analgesic against CIPN as well as a co therapy to enable o ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. A novel smartphone-based tool to quantify dual-task gait performance for concussion assessment

    SBC: Control One LLC            Topic: NINDS

    Project Summary Sport related concussions are a serious public health concern in the United Stateswithtomillion concussions reported annuallyYoung athletes who suffer a concussion experience quality of life alterationswith cognitive impairmentreduction in balance or coordinationand memory lossUnfortunatelyseveral factors limit the ability to accurately and feasibly evaluate the deleterious effects ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Therapeutic in Situ Analgesic Implant for improved Oral-Facial Post-Operative Pain Outcomes

    SBC: Epigen Biosciences, Inc.            Topic: NIDCR

    PROJECT SUMMARY Analgesia for post operative populations remains a significant health need that calls for innovative therapies which improve both safety and outcome measuresRecent FDA drug safety warnings and studies focusing on post operative analgesia have highlighted the imperative need for new approaches that can be utilized for common clinical scenariosAccordinglynovel treatment options that ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Implantable Peripheral Nerve Stimulator for Treatment of Phantom Limb Pain

    SBC: RIPPLE, LLC            Topic: 999

    Abstract Chronic phantom limb painPLPhas been reported to inflict as many asof people with amputationsPLP is described as feeling like burningtwistingitchingor pressure in part of the missing limbThese painful sensations have a substantial negative impact on quality of lifepeople who suffer PLP have high rates of depressiondifficulty sleepingregular absences from workdissociation with family frien ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A high oxygen capacity cell scaffold for the intravascular bioartifical pancreas (iBAP)

    SBC: Silicon Kidney            Topic: 200

    PROJECT SUMMARY TypeDiabetesT Daffects nearlymillion people in the United States overmillion people globallyA subset of patients have unstable T D because they possess poor glycemic control and severe hypoglycemia unawarenessWhile whole organ pancreas and islet transplantation can cure unstable T Dthese treatments are limited by immunosuppression therapy and scarcity of donor tissueIn contrastenca ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Development and Validation of Novel Coatings that Extend Glucose Sensor Accuracy and Lifespan in vivo

    SBC: Cell And Molecular Tissue Engineering LLC            Topic: NIDDK

    An overarching factor in the development of any successfulartificial pancreassystem is the advancement of a highly accurate and long lived glucose sensorwithout the need for numerous recalibrationsFrequentlyimplantable glucose sensors demonstrate insufficient reliability with respect to performanceaccuracy and response timewhich is thought to be the result of poor biocompatibilityCentral to these ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Pharmacokinetic and toxicology studies of AYX2, a transcription factor decoy, non-opioid, disease modifying drug candidate for the long-term treatment of chronic pain

    SBC: Adynxx, Inc.            Topic: NINDS

    RESEARCH AND RELATED OTHER PROJECT INFORMATIONPROJECT SUMMARYABSTRACTFunding OpportunityPAPI NameMametJulienAs described by the HEAL Initiative Notice NOT NSthere currently exists an urgent unmet need for enhanced pain management in the form of safeeffectivenon opioid pain treatmentsChronic focal neuropathic painwhich includes pain etiologies such as radiculopathy and radiculitisfocal peripheral n ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Beyond Screen Time: Developing an objective mobile media measurement tool

    SBC: OpenLattice, Inc.            Topic: NICHD

    PROJECT ABSTRACT Excessive digital media use has been linked with several adverse health outcomes in childrenincluding obesitydisrupted sleepexternalizing behaviorand executive functioning deficitsbut measurement tools have not kept pace with the advancements in digital technology now used in most American householdsFor examplemost American families with young children now own a smartphoneor table ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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