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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Improving drug safety for pregnant women by delivering current and authoritative information via mobile devices

    SBC: RightAnswer.Com, Inc.            Topic: NCBDDD

    Project SummaryAbstract! An!estimated!!infants!delivered!annually!in!the!United!States!are!born!with!birth!defects!caused!by!the!use!of! medication!during!pregnancy !!Since!the!peak!prevalence!of!some!diseases !such!as!hypertension !autoimmune!disease ! and!depression !occurs!during!the!childbearing!years !it!is!not!surprising!that!medication!use!during!pregnancy!is! common !with!nine!out!of!ten!p ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. Topic 375: 18F PET Tracer For Imaging PD-L1 (Moonshot)

    SBC: SIBTECH, INC.            Topic: NCI

    New therapies, designed to enhance anti-tumor immunity are based on the blockade of the checkpoint components, either PD-1 on immune cells or PD-L1 on tumor cells. This strategy, while being spectacularly successful in some patients for some cancers, fails for many other patients. The expression of PD-L1 is highly dynamic and its prevalence within tumors can vary significantly over time. The curre ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. A Method to Increase Buprenorphine Treatment Capacity and Effectiveness

    SBC: CBT4CBT, LLC            Topic: R42

    The goal of this fast track STTR proposal is to expand buprenorphine maintenance therapy for opioiddependent patientsOvermillion people in the US are addicted to opiatesProviding effective agonist therapymethadone or buprenorphinecoupled with behavioral counseling greatly improves outcomesreduces morbidityand reduces societal costsMethadone maintenance treatment has been limited due to complex sta ...

    STTR Phase II 2018 Department of Health and Human Services
  4. Validating the MicroKine Assay for Use in Identifying Personalized Precision Therapies for Pediatric Sepsis

    SBC: PreDxion Bio, Inc.            Topic: NICHD

    Project Summary Abstract PreDxion BioLLC is a precision medicine diagnostic company developing an assay platformthe MicroKineassay cartridge and readerthat measures serum proteins in less thanminutes from a single drop of bloodThis fastactionable information allows for the first time individualized precision medicine aimed at reducing pediatric morbidity and mortality in pediatric sepsisthe number ...

    STTR Phase I 2018 Department of Health and Human Services
  5. Development of an Oral Acidic Mammalian Chitinase Inhibitor to Treat Asthma

    SBC: ONCOARENDI THERAPEUTICS LLC            Topic: NHLBI

    Approximatelymillion Americans suffer from asthmawhich leads to aboutdeaths per yearand is responsible for estimated annual total direct and indirect costs of $billionDespite the existing treatments for asthmapredominantly combinations of inhaledagonists and corticosteroidsCSsthere remains a significant unmet medical need for new therapies which address two key issuesapproximatelyof patients are i ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Commercial Software Using High-throughput Computational Techniques to Improve Genome Analysis

    SBC: Genomenon, Inc.            Topic: 172

    Recent advances in DNA sequencing technology have not been matched by improved analytic techniques to quickly and accurately interpret patient genome data to inform diagnosisprognosis and therapy making decisions in the clinic and to identify candidate biomarkers of disease in research laboratoriesDevelopment of automated techniques to facilitate interpretation of this data will benefit patient ca ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. A Noninvasive Prenatal Testing Platform for Aneuploidy at Five Weeks of Gestation

    SBC: Advanced Reproductive Testing, L.L.C.            Topic: NICHD

    The overall goal of this research is to provide a flexible prenatal genetic testing kit that can be expanded to detectany inheritable trait as early asand up toweeks of gestationfrom a safenoninvasive Pap smearStudiesshow that perinatal Pap tests pose no risk to mother or fetusand capture trophoblastlike cells that migrate fromtheplacentaintothereproductivetractTrophoblastretrievalandisolationfrom ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Targeting Exonuclease Resistant RNA to Develop Zika Virus Therapeutics

    SBC: NYMIRUM, INC.            Topic: NIAID

    Project Summary Abstract Outbreaks of Zika VirusZIKVhave been recorded in Africathe AmericasAsiaand the Pacificand despite significant resources being dedicated to combat ZIKV proliferationthere is no known cureMany mosquitoborne flavivirus such as ZIKVDengue virusYellow Fever virusand West Nile virus have structuredUTRsStructured RNA elements in theUTRs allow the virus to resist degradation by ho ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Antimicrobial Intravascular Catheter Lock Solutions Based on Endogenous Nitric Oxide Release Agent

    SBC: NOTA Laboratories LLC            Topic: NIAID

    ! AbstractIntravascularIVcatheters in the hospital setting are associated with a high rate of bacterial colonizationresulting in andgtdeaths annually in the U Sfrom catheter related blood stream infectionsCR BSIsNewer commercial catheters pre loaded with silver or antibiotics within their walls have failed to dramatically reduce this very significant problemA variety of catheter lock solutionscath ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Production and Characterization of Human Immunoglobulin Producing Goats for Diagnostic Reagents and Therapeutics

    SBC: SAB Capra LLC            Topic: NIAID

    Project Summary A research plan is proposed to engineer goats that produce fully human immunoglobulinThese animals will be evaluated as a candidate platform system for production of both targeted therapeutic immunoglobulin as well as reagent antibodies for standards and controls of serological assays of human clinical samplesPrevious studies have demonstrated that ungulates such as cattle can prod ...

    STTR Phase I 2018 Department of Health and Human Services

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