Award Data

PROJECT SUMMARY / ABSTRACTThe objective of this Phase II proposal is to further develop a novel device for ocular anesthesia based on thermo-electric cooling. Intravitreal injection therapy (IVT) is one of the most commonly performed procedures in all of medicine, with approximately 7 million injections in the USA in 2016. Ocular anesthesia is required, both for patient safety and for tolerability ...

Project SummaryAbstract! An!estimated!!infants!delivered!annually!in!the!United!States!are!born!with!birth!defects!caused!by!the!use!of! medication!during!pregnancy !!Since!the!peak!prevalence!of!some!diseases !such!as!hypertension !autoimmune!disease ! and!depression !occurs!during!the!childbearing!years !it!is!not!surprising!that!medication!use!during!pregnancy!is! common !with!nine!out!of!ten!p ...

Chemotherapy may control but rarely cure metastatic cancers. Remarkably, modern immunotherapies, including cell-based therapies, have cured metastatic melanomas and other types of cancers. A major challenge for all cell therapies in general is the need to develop cost-effective and efficient manufacturing and delivery capabilities. We have recently established an innovative cell isolation technolo ...

Project Summary/Abstract Prospective evaluation of a surgical solution for breast cancer-associated lymphedema The proposed project will complete remaining key research and technology requirements that are needed to commercialize a ground-breaking interventional device for treating secondary lymphedema -- a chronic and debilitating disease that currently has no cure and impacts an estimated 15-30% ...

The Missile Defense Agency seek solid propellant, propulsion control systems with longer operation times, increased performance, and reduced size, weight, power, and cost.Solid propellant exhaust gases are commonly 2,000-4,000F.Proportionally controlled actuators that are capable of enduring higher temperatures while aiming to maintain performance and/or reduce SWaP-C will improve the robustness o ...

To address the Missile Defense Agency (MDA) need for tooling and processes for repeatable adhesive dispensing onto threaded fasteners in missile production, Physical Optics Corporation (POC) proposes, in Phase II, to advance development of the new Locking Adhesive DIspensing onto threaded Fasteners (LADIF) system. During Phase I effort, POC developed and demonstrated the feasibility of the LADIF c ...

Novel algorithms for improving the performance of IMU without changing the sensor hardware were demonstrated during the Phase I research. These improvements consisted of higher-order nonlinear transfer alignment and calibration filters incorporating detailed models of sensor uncertainties, de-noising algorithms to eliminate the impact of shock and vibration on the IMU navigation solution, and more ...

The efforts will leverage advanced multi-scale material modeling, multi-physics additive manufacturing (AM) simulation technologies to suggest optimized AM process and build parameters before printing in an attempt to deliver quality Direct Metal Laser Sinteringparts.Components/materials fabricated will meet MDA/Raytheon specifications. The qualification of each component will be shown by DOE, and ...

To address the MDAs need for a repeatable manufacturing process for aerospace-grade, thinned-walled aluminum alloy propellant tanks, Physical Optics Corporation (POC) developed the new Robotic Bonding (ROBOBOND) system, which utilizes conventional computer numeric control (CNC) machinery to perform friction stir welding (FSW) with minimum setup, allowing the technology to become widely available. ...

A key requirement for IR sensors in interceptor seekers is to continue to image through adverse environments, including the radiation from nuclear events. This radiation hardening requirement is addressed with a multifaceted approach that includes a novel filter, implemented in the unit cell, that mitigates the effects of gammas, betas, and protons, while leaving the IR signal unaltered. Other rad ...