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Project Summary We propose a two-arm adaptive Phase II clinical trial to evaluate ONC201, a selective antagonist of the G protein-coupled receptor (GPCR) dopamine receptor domain 2 (DRD2), in recurrent glioblastoma (GBM) and diffuse midline glioma associated with very poor prognoses and limited treatment options. DRD2 is overexpressed in high grade gliomas and controls Akt/ERK signaling pathways. ...

PROJECT SUMMARY / ABSTRACTThe objective of this Phase II proposal is to further develop a novel device for ocular anesthesia based on thermo-electric cooling. Intravitreal injection therapy (IVT) is one of the most commonly performed procedures in all of medicine, with approximately 7 million injections in the USA in 2016. Ocular anesthesia is required, both for patient safety and for tolerability ...

Project SummaryAbstract! An!estimated!!infants!delivered!annually!in!the!United!States!are!born!with!birth!defects!caused!by!the!use!of! medication!during!pregnancy !!Since!the!peak!prevalence!of!some!diseases !such!as!hypertension !autoimmune!disease ! and!depression !occurs!during!the!childbearing!years !it!is!not!surprising!that!medication!use!during!pregnancy!is! common !with!nine!out!of!ten!p ...

There is an urgent need for more effective drug delivery agents for treatment of brain tumors, which are among the most aggressive and intractable cancers. SapC-DOPS, a nanovesicle composed of saposin C (SapC) coupled to dioleoylphosphatidylserine (DOPS), has proven tumor targeting properties, which include crossing the blood-brain tumor barrier and binding the lipid tumor marker, extracellular ph ...

Chemotherapy may control but rarely cure metastatic cancers. Remarkably, modern immunotherapies, including cell-based therapies, have cured metastatic melanomas and other types of cancers. A major challenge for all cell therapies in general is the need to develop cost-effective and efficient manufacturing and delivery capabilities. We have recently established an innovative cell isolation technolo ...

Project Summary/Abstract Prospective evaluation of a surgical solution for breast cancer-associated lymphedema The proposed project will complete remaining key research and technology requirements that are needed to commercialize a ground-breaking interventional device for treating secondary lymphedema -- a chronic and debilitating disease that currently has no cure and impacts an estimated 15-30% ...

NeurocycsticercosisNCCis a leading cause of adult onset epilepsy in the developing world and an increasing public health concern in the United StatesNCC develops in individuals infected with tape worm Taenia soliumTsoliumHowevermost people are unaware of their infection before neurological symptoms appearthus posing a major risk of transmitting the infectionReliable diagnosis and efficacious treat ...

As the major cause of acquired epilepsy in developing countriesNeurocysticercosisNCCis the infection of the human nervous system by the larvae of the pork tapewormTaenia soliumReportable cases are seen in non endemic countries because of increasing travel and immigrationMany infected persons are unaware of their infection or the potential risks of transmission to othersIt is important to control a ...

This proposal focuses on a solution that would address the above issues by enabling a compact and completely automated closed platform that allows DNA libraries preparation from clinical samples for deep sequencing on the MiSeq Illumina systemThe resulting benefits would be process efficiency and accessibility to NGS in parts of the world where proper laboratorieshighly skilled personnelor simply ...

The long term goal of this project is to improve public health through the reduction of the spread of HIVHepatitis C virusand other health concerns among persons who use injection drugsPWIDPWID who share needlessyringesand other drug preparation equipment face an increased risk for bloodborne infectionsincluding HIVHepatitis C virusHCVand Hepatitis B virusHBVAn effective means for reducing the tra ...