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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 368: Biotherapy of Brain Tumors by Radioiodinated SapC-DOPS Nanovesicles

    SBC: Molecular Targeting Technologies, Inc.            Topic: NCI

    There is an urgent need for more effective drug delivery agents for treatment of brain tumors, which are among the most aggressive and intractable cancers. SapC-DOPS, a nanovesicle composed of saposin C (SapC) coupled to dioleoylphosphatidylserine (DOPS), has proven tumor targeting properties, which include crossing the blood-brain tumor barrier and binding the lipid tumor marker, extracellular ph ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 375: 18F PET Tracer For Imaging PD-L1 (Moonshot)

    SBC: SIBTECH, INC.            Topic: NCI

    New therapies, designed to enhance anti-tumor immunity are based on the blockade of the checkpoint components, either PD-1 on immune cells or PD-L1 on tumor cells. This strategy, while being spectacularly successful in some patients for some cancers, fails for many other patients. The expression of PD-L1 is highly dynamic and its prevalence within tumors can vary significantly over time. The curre ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 372: Development and Validation of Canine scFvs for Pre-Clinical Development of Targeted Therapeutics- Moonshot

    SBC: Vetigenics LLC            Topic: NCI

    The goal of this SBIR is to provide proof-of-concept of Vetigenics' canine-derived scFv phage display platform for rapid, cost effective production of highly versatile, canine-derived scFvs. scFvs against CD19, CD3 and CTLA4, three high-value, immunological molecules being targeted by antibody-based strategies in human cancer immunotherapy, will be isolated. Selected scFvs will be sequenced and bi ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Topic 373: Monoclonal Antibodies to RNA-modifications

    SBC: Abzyme Therapeutics, LLC            Topic: NCI

    Post-transcriptional RNA modification is quite complex as there are more than sixty known RNA modifications that occur in thousands of RNAs in eukaryotic cells. A number of these RNA modifications have been shown to influence the development and physiology of the central nervous system (CNS) and to be involved in carcinogenesis. Despite the growing interest in and importance of RNA modifications, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Topic 373: Novel Mass Spectrometry Methods and Research Tools to Map Nucleotide Modifications in Cytosolic Transfer RNAs from Cancer Cells

    SBC: Ribonova Inc.            Topic: NCI

    Chemical modifications play a crucial role in the regulation of biological processes. Protein function is often modulated by tagging with phosphates, sugars, or lipids, while epigenomic marks on DNA or histones can regulate gene expression up or down. One area that lags behind is the mechanistic understanding of the role of RNA chemical modifications, sometimes referred to as the 'epitranscriptome ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Creation of an Accurate Model of the Topical Structure of PubMed and associated indicators

    SBC: SCITECH STRATEGIES, INC            Topic: NIDA

    NIH through NIDA seeks development of an advanced and sophisticated analytical tool and approaches to enhance the professional evaluation and decision support in life sciences management and administrationIn this Phase II project the Contractor will continue to develop indicators of impactful science and of how virtuous the research ise gtransparencyreproducibility and potential for translation ap ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. The objective of this contract is to determine the feasibility of a clofazimine inhalation formulation for preclinical development in tuberculosis

    SBC: QrumPharma, Inc.            Topic: NIAID

    Multi drug resistant tuberculosisMDR TBis now estimated to be responsible fornew infections annuallyObservational studies have demonstrated the addition of clofazimine to MDR TB treatment regimens is an effective therapeutic strategy for clearing infections and improving patient outcomesHowevercurrent treatment regimens are longand prolonged systemic administration of clofazimine causes severe sid ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. SBIR Topic 089, Phase II, In-bore Defibrillation for Invasive MRI Cardiology Procedures

    SBC: PINMED, INC.            Topic: NHLBI

    The goal of the project is to develop an external cardiac defibrillator system for operation inside the MRI borePhase I would develop and test a working prototype in vivoPhase II would further develop the system and complete regulatory development to allow clinical testing in patients

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. SBIR Topic 105, Phase I, Reagent Development for Small Cell Number ChIC-seq

    SBC: AlphaThera            Topic: NHLBI

    The project goal is to develop reagents that can be used for mapping genome wide epigenetic changes during normal development and disease process in rare primary and patient cellsBecause conjugating proteins could result in inactivation of the proteinsit will be important to achieve efficient conjugation between antibodies and MNase while reserving the activities of both

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Development of “Permit Wizard” Software for AssistedPermit Application Completion

    SBC: Total Quality Systems, Inc.            Topic: 833

    TECHNICAL ABSTRACT: The objective of this project is to research the technical feasibility of designing a software tool “Permit Wizard” that will automate the process for aquamarine permit application submittal, review, approval/disapproval and issue (including collection of fees). Aquaculture producers are currently faced with slow, complex, and often confusing permitting processes that must ...

    SBIR Phase I 2018 Department of CommerceNational Oceanic and Atmospheric Administration

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