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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Adaptive Clinical Efficacy Evaluation of ONC201 in Recurrent High Grade Glioma

    SBC: Oncoceutics, Inc.            Topic: 102

    Project Summary We propose a two arm adaptive Phase II clinical trial to evaluate ONCa selective antagonist of the G protein coupled receptorGPCRdopamine receptor domainDRDin recurrent glioblastomaGBMand diffuse midline glioma associated with very poor prognoses and limited treatment optionsDRDis overexpressed in high grade gliomas and controls Akt ERK signaling pathwaysDownstream of target engage ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Improving drug safety for pregnant women by delivering current and authoritative information via mobile devices

    SBC: RightAnswer.Com, Inc.            Topic: NCBDDD

    Project SummaryAbstract! An!estimated!!infants!delivered!annually!in!the!United!States!are!born!with!birth!defects!caused!by!the!use!of! medication!during!pregnancy !!Since!the!peak!prevalence!of!some!diseases !such!as!hypertension !autoimmune!disease ! and!depression !occurs!during!the!childbearing!years !it!is!not!surprising!that!medication!use!during!pregnancy!is! common !with!nine!out!of!ten!p ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Topic 368: Biotherapy of Brain Tumors by Radioiodinated SapC-DOPS Nanovesicles

    SBC: Molecular Targeting Technologies, Inc.            Topic: NCI

    There is an urgent need for more effective drug delivery agents for treatment of brain tumors, which are among the most aggressive and intractable cancers. SapC-DOPS, a nanovesicle composed of saposin C (SapC) coupled to dioleoylphosphatidylserine (DOPS), has proven tumor targeting properties, which include crossing the blood-brain tumor barrier and binding the lipid tumor marker, extracellular ph ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Finding Human Carriers of Taeniasis to Prevent Neurocysticercois Associated Epilepsy

    SBC: APTAGEN LLC            Topic: ODCDC

    NeurocycsticercosisNCCis a leading cause of adult onset epilepsy in the developing world and an increasing public health concern in the United StatesNCC develops in individuals infected with tape worm Taenia soliumTsoliumHowevermost people are unaware of their infection before neurological symptoms appearthus posing a major risk of transmitting the infectionReliable diagnosis and efficacious treat ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Shallow Water Bathymetric Survey Systems

    SBC: CREARE LLC            Topic: 829

    TECHNICAL ABSTRACT: Ship groundings can cause sever environmental damage to the delicate ecosystems such as coral reefs, seagrass beds, and beaches. At present, survey work is performed by hand – a method that is inefficient and difficult to perform reliably. Improved bottom survey tools are clearly needed to evaluate the extent and type of damage and assist in determining remediation efforts. ...

    SBIR Phase I 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  6. Autonomous Meteorological Measurement System

    SBC: CREARE LLC            Topic: 8212

    TECHNICAL ABSTRACT: NOAA and the National Weather Service maintain an immense network of automated maritime, surface, and upper-air observing stations throughout the world and at great expense. These automated stations provide regularly updated data for both short-term weather prediction and long-term climate models. Maritime and surface observations occur as frequently as every 10 to 20 minutes, ...

    SBIR Phase I 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  7. Development of “Permit Wizard” Software for AssistedPermit Application Completion

    SBC: TOTAL QUALITY SYSTEMS, INC.            Topic: 833

    TECHNICAL ABSTRACT: The objective of this project is to research the technical feasibility of designing a software tool “Permit Wizard” that will automate the process for aquamarine permit application submittal, review, approval/disapproval and issue (including collection of fees). Aquaculture producers are currently faced with slow, complex, and often confusing permitting processes that must ...

    SBIR Phase I 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  8. Clean Energy Source to Power NOAA Long-termObservation and Monitoring Networks

    SBC: CREARE LLC            Topic: 8211

    TECHNICAL ABSTRACT: Creare proposes to develop a self-sustained small-scale power conversion system to power NOAA’s weather monitoring network stations located in harsh uninhabited locations. Our miniature heat engine will take advantage of the existing year-round thermal gradients found between water and air in Arctic regions. Our baseline approach is the development of a compact Turbo-Rankine ...

    SBIR Phase I 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  9. Doppler Wind Temperature Sounder

    SBC: Brandywine Photonics, LLC            Topic: 8212

    TECHNICAL ABSTRACT: We propose developing a new observational capability for measuring upper atmosphere (20-Km to 200-Km+ altitude) wind and temperature dynamics, based on Doppler imaging of Limb concentrations of NO, N2O, and CO2 called the Doppler Wind Temperature Sounder. The principle of operation is that by measuring the Doppler shift of trace gases created by the differential velocity betwee ...

    SBIR Phase I 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  10. Open Water- A Citizen Science Monitoring Platform

    SBC: CREARE LLC            Topic: 833

    TECHNICAL ABSTRACT: Ensuring the health of coastal marine ecosystems has emerged as one of the primary environmental concerns of this century. Frequent monitoring of water quality is required to establish baseline levels and enable early detection of problems. Citizen science programs have been shown to provide a highly effective method of monitoring water quality. Creare is developing an open-sou ...

    SBIR Phase II 2018 Department of CommerceNational Oceanic and Atmospheric Administration
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