Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Measuring toxicant effects on cellular function in a microarray format

    SBC: CIENCIA INC            Topic: 113

    Project Summary AbstractThe EPA maintains a Toxics Release Inventory of andgttoxic chemicals that are disposed or released from andgtindustrial sites in the United Stateswhile HHS and USDA maintain a list of overselect agents and toxicants that pose a severe risk to humananimaland plant healthThese compounds represent only a fraction of the known and unknown environmental toxicants that may advers ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Discovery of T-type Calcium Channel Antagonists from Multicomponent Reactions and Their Application in Paclitaxel-induced Peripheral Neuropathy

    SBC: Regulonix            Topic: 101

    Summary Abstract Chemotherapy induced peripheral neuropathyCIPNis detected inof cancer patients during all phases of cancerSensory symptoms in the hands and or feettypically in astocking glovepatternare commonand manifested as painnumbnessand or tinglingCIPN can result in chemotherapy dose reduction or discontinuationand can also have long term effects on the quality of lifeThe course of CIPN can ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. A novel vaccine against mosquito-borne Zika virus based on mosquito salivary gland protein AgBR1

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    PROJECT SUMMARYZika virusan emerging flavivirusis associated with severe clinical outcomesincluding Guillain Barrsyndrome and birth defectsTransmission of Zika virus is primarily mosquitoborneMosquito salivary proteins are known to enhance infectivity and pathogenesis in Zikadengue and West Nile viruses by modulating immune responsesThis proposal seeks to develop a novel vaccine against Zika virus ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development of mitoNEET agonists for the treatment of stroke

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    ABSTRACT Stroke is the fifth leading cause of death and the leading cause of disability in the United StatesThere remains a critical need for innovative therapeutic approaches that can successfully prevent or reverse brain injury following strokeDysfunction of the mitochondrial biochemistry following ischemic stroke and reperfusion injury contributes to significant neuronal cell losshoweverthe dev ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. The Antibody Registry: A Community Authority for Antibody Research Resource Identifiers

    SBC: SCICRUNCH            Topic: 300

    Project SummaryOne of the most glaring yet easily addressable gaps in our current scientific workflow and publication system is improving the way that methods are reportedin particularthe lack of key methodological details necessary for interpreting and reproducing a studyMost authors continue to cite the name of the reagentlike an antibody using the vendorand the city where the vendor is locatedb ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. BlueBox: A Complete Code Blue Data Recorder, Phase II

    SBC: NeoVative, Inc.            Topic: 400

    Code blueis the signal used in hospitals to call for an immediate cardiopulmonary resuscitationCPRfollowing a cardiac or respiratory arrestReviewing the performance of thecode blue teamis a cornerstone for improving outcomesThe current standard of using handwritten records on a papercode sheetdoes not allow measurement of key quality indicators and is subject to human errorIn the Phase I STTR proj ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Glioblastoma multiforme therapy via telomerase reverse transcriptase (hTERT) down-regulation. Molecular chaperones redirect quadruplex folding to reverse the effect of hTERT gene promoter mutations.

    SBC: Reglagene, LLC            Topic: 106

    Project Summary Overexpression of hTERT is a hallmark of cancer and is associated with oncogenesistumor maintenanceand resistance to conventional chemotherapyElongated telomeres at the ends of chromosomes are a hallmark for cancer in the early stage of tumorigenesis and are associated with genetic instabilityAs a consequencesuppressed telomerase in normal cells is highly activated to immortalize t ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. A Novel Two-in-One Approach to Administer Surfactant and Provide Airway Support to VLBW Infants

    SBC: BB MEDICAL SURGICAL, INC            Topic: NICHD

    PROJECT SUMMARYABSTRACT Every yearvery low birth weightVLBWandltginfants are born in the U SThe use of surfactant dramatically decreases morbidity and mortality due to respiratory distress syndromeRDSin VLBW infantsCurrent standards for surfactant administration require the infant to be intubatedso that surfactant can be delivered to the trachea and lungsIntubating a VLBW infant is challenging and ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Ultra-sensitive Rapid Diagnostic Test to Support the End-Game of the Global Program to Eliminate Lymphatic Filariasis

    SBC: NANOCOMPOSIX INC            Topic: NIAID

    Project SummaryAbstract Lymphatic filariasisLFcaused by the parasitic filarial worm Wuchereria bancroftiis a disfiguring and debilitating neglected tropical disease that affectsmillion people incountriesThrough the World Health Organization sWHOGlobal Program for the Elimination of Lymphatic FilariasisGPELFbillion drug regimens have been distributed via mass drug administrationMDAtomillion people ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Novel Therapeutic Antibody Targeting of Extracellular NAMPT in Ventilator-Induced Lung Injury (VILI)

    SBC: AQUALUNG THERAPEUTICS CORP.            Topic: NHLBI

    PROJECT SUMMARYMortality rates in intensive care unitsICUsare unacceptably high and are directly related to the duration of mechanical ventilation that is required to support patients with respiratory failureFor exampleacute respiratory distress syndromeARDSis a vexing acute inflammatory lung disease requiring mechanical ventilatory support as the result of severe hypoxemia and respiratory failure ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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