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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 1 - 10 of 4372 results
  1. Geostatistical Software for Non-Parametric Geostatistical Modeling of Uncertainty

    SBC: BIO-ANALYTICS, INC.            Topic: NLM

    7. Project Summary/Abstract A key component in any investigation of association and/or cause-effect relationships between the environment and health outcomes is the availability of accurate and precise models of exposure. Because the cost of collecting field data is often prohibitive, it is critical to incorporate any source of secondary information available to supplement sparse datasets. Seconda ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Cybernetic Training for Autonomous Robots- Human Augmentation via Generalizable Mobile autonomous Robot Dexterity (C-H)

    SBC: Sarcos Group LC            Topic: AF193CSO1

    The Sarcos Cybernetic Training for Autonomous Robots - Human Augmentation via Generalizable Mobile Autonomous Robot Dexterity (C-H) program is a second Air Force SBIR Phase II. C-H advances Sarcos’ vision of leveraging the expertise of competent task perf

    SBIR Phase II 2023 Department of DefenseAir Force
  3. 3D Printed Silicon Nitride Porous PEEK Composite Spinal Cages for Anti-Infection

    SBC: SINTX TECHNOLOGIES, INC.            Topic: NIAMS

    PROJECT SUMMARYSpinal fusion is the standard treatment for persistent neck and back pain, but the hardware used to stabilize the fusion can harbor or even promote bacteria that lead to persistent, difficult-to-treat infections that are costly and damaging to patient health. Among the available materials for spinal fusion, polyether-ether-ketone (PEEK) cages stand out due to their strength, biocomp ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. A Potent D-peptide Inhibitor of TNFα for Treatment of Rheumatoid Arthritis

    SBC: D BioTherapeutics, LLC            Topic: NIAMS

    Rheumatoid arthritis (RA) is a chronic, debilitating inflammatory disease with high medical and societal costs afflicting more than 1.6 million Americans. Blockade of TNFα-driven inflammation with approved anti-TNFα biologics (such as Humira®, Remicade®, Simponi®, and Enbrel®) is an effective treatment for many patients suffering from RA. However, due at least in part to the immunogenicity o ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Integrated, Resilient, and Highly Adaptable Aerospace Information Networks

    SBC: OWL Integrations, Inc.            Topic: X22DOTCSO1

    United States Air Force S&T identifies five strategic capabilities: 1) Global Persistent Awareness,  2) Resilient Information Sharing, 3) Rapid, Effective Decision-Making, 4) Complexity, Unpredictability, and Mass, and 5) Speed and Reach of Disruption and

    STTR Phase II 2023 Department of DefenseAir Force
  6. GMP Manufacturing and IND Enabling Studies of Extended-Release PNA5: ANovel Therapeutic for Treating Cognitive Impairment in Patients at-risk for Alzheimer's Disease-Related Dementias and Vascular

    SBC: Proneurogen, Inc            Topic: NIA

    Vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer’s disease related dementias (ADRD) significantly contribute to the 47 million people world-wide who suffer with dementia. This number is estimated to increase to over 130 million people by 2050. Several studies have shown that VCID and conversion to ADRD are strongly correlated with vascular disease, inflammation an ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Novel Extracorporeal Device 'Amytrapper' To Remove Beta Amyloid In Alzheimer'sDisease

    SBC: Recombinant Technologies LLC            Topic: NIA

    Abstract Alzheimer’s disease is the most common cause of dementia and fourth most common cause of death. Amyloid-beta (Aβ) plays a crucial role in initiation and progression of Alzheimer’s disease (AD). Removal of circulating Aβ would shift the equilibrium in Aβ levels between brain and blood towards blood. This shift would deplete brain amyloid levels and improve memory. Three commercial m ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Commercial translation of high-density carbon fiber electrode arrays for multi-modal analysis of neural microcircuits

    SBC: BLACKROCK MICROSYSTEMS, INC            Topic: 106

    ABSTRACT The ability to measure and manipulate local brain circuit activity in living, behaving animals is essential to understanding the complexities of brain function and dysfunction. A novel, penetrating high-density carbon fiber electrode array composed of flexible, ultrathin conductive carbon microfibers was recently developed under the BRAIN Initiative to study neural microcircuit dynamics. ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Method for the validation by Western analysis of affinity reagents against post-translationally modified proteins.

    SBC: ABBRATECH INC.            Topic: 400

    ABSTRACT Antibodies (Abs) are commonly employed in biomedical research to identify and quantify target proteins. However, the specificity, sensitivity and reliability of these Abs can be variable, which is a significant concern in the scientific community. The use of an incorrect Ab can result in misleading or inaccurate results, impeding progress in various areas of biomedical research. In Phase ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. PET Imaging of Damaging Neuroinflammation in Alzheimer's Disease

    SBC: EINSENCA INC.            Topic: NIA

    Alzheimer's disease (AD) is a devastating and progressive disease without a cure. Neuroinflammation is now recognized as a key early event in the development of AD. Aberrant neuroinflammatory response activates immune cells that can increase oxidative stress, and oxidative stress can directly damage neurons and axons, cause demyelination, and break down the blood-brain barrier (BBB). Thus, damagin ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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