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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Whole-brain fluorescence and brightfield imaging at single-cell level
SBC: DMetrix, Inc Topic: NIADESCRIPTION (provided by applicant): The goal of this project is to develop an open and flexible imaging platform capable of rapid, 0.5- 5 m pixel resolution image capture of large-area histology sections (up to 125 mm by 175 mm), in brightfield and by epi-fluorescence optical sectioning. The project involves state-of-the- art instrumentation development coupled with application programming inter ...
SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health -
Therapeutic Inhibition of MIF in Rheumatoid Arthritis
SBC: L2 DIAGNOSTICS LLC Topic: NIAMSDESCRIPTION (provided by applicant): The long-term product goal of this project is a small molecule therapeutic to treat rheumatoid arthritis (RA), which acts by reducing the inflammatory response triggered by the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF). Since MIF is an upstream regulator of the inflammatory cascade, small molecule therapeutics targeting MIF activity ...
SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health -
Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer
SBC: JSK THERAPEUTICS INC. Topic: NCIDESCRIPTION (provided by applicant): Despite notable achievements over the past two decades, cancer remains a challenging 21st century epidemic demanding new, more effective drugs. Nitric oxide (NO) is well known to kill cancer cells without harming normal bone marrow cells, but until now has not been used directly to treat cancer because of its effect to lower blood pressure. JSK Therapeutics (J ...
SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health -
Ex Vivo Tolerance for Xenotransplantation of Diabetes P2
SBC: XIMEREX, INC. Topic: NIDDKDESCRIPTION (provided by applicant): Type I diabetes is a widespread disease in which insulin producing pancreatic islets are lost, leading to unstable glucose levels. If the islets can be replaced, as with transplantation, then diabetes can be reversed.Human islets have limited utility because of a severe shortage of donors and the need for constant immune suppression to prevent rejection. Pigs ...
SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health -
NOVEL HIGH THROUGHPUT PLATFORM FOR SCREENING CYTOCHROME P450 INDUCTION
SBC: ORIGINUS, INC. Topic: NIEHSDESCRIPTION (provided by applicant): Many prescribed drugs exhibit drug-drug interactions due to up-regulation or inhibition of specific P450 enzymes. According to a recent guidance from the FDA, CYP1A2, CYP2B6, and CYP3A4 induction should be evaluated inat least an in vitro system. Enzymatic activity in freshly isolated hepatocytes is the Gold Standard for studying P450 induction; however, it ...
SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health -
An Antisense Design and Simulation Platform
SBC: DNA SOFTWARE, INC. Topic: NIGMSDESCRIPTION (provided by applicant): In this grant proposal An Automated Antisense Design and Simulation Platform , a comprehensive molecular diagnostics software tool that is specific to the design and simulation of antisense oligonucleotide analog probes will be developed. The application of antisense technologies to the study of human diseases has been proven in the literature for cancer, im ...
SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health -
Novel Micro-Implant to Measure Intracardiac Pressure in Congenital Heart Patients
SBC: Integrated Sensing Systems Incorporated Topic: NHLBIDESCRIPTION (provided by applicant): Congenital heart disease patients with functional single ventricle (FSV) anatomy usually require a series of surgeries during infancy and childhood in order to provide them with a chance to survive into adulthood. The second stage surgery, termed the hemi-Fontan procedure (HFP) re-routes systemic venous blood from the upper body and head into the pulmonary circ ...
SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health -
Selective Cytopheresis Therapy in Systemic Inflammatory Response Syndrome
SBC: Innovative Biotherapies, Inc. Topic: NCATSDESCRIPTION (provided by applicant): Leukocytes (LE) are major contributors to the pathogenesis and progression of many clinical inflammatory disorders, including the systemic inflammatory response syndrome, sepsis and acute respiratory distress syndrome.The need for new and innovative therapies to treat these inflammatory disease states presents a large commercial market opportunity. A large numb ...
SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health -
Implantable Myoelectric Recording Array for Control of Prostheses
SBC: RIPPLE LLC Topic: NINDSDESCRIPTION (provided by applicant): The goal of this translational SBIR program is to create a small, implantable system for recording myoelectric signals from residual and reinnervated muscles of individuals with forearm and other amputations. The signals will be wirelessly coupled to an external receiver for controlling prostheses. Compared to conventional surface electrodes, this system will p ...
SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health -
The Memory Care Navigator: A Proactive Guide
SBC: Proactive Memory Services Topic: NIADESCRIPTION (provided by applicant): Alzheimer's disease (AD) is an irreversible neurological disease that progressively causes a tremendous toll in disability and societal cost. As our population ages, AD and other memory disorders will become increasingly prevalent. Patients and their families often find themselves lost in a complex web of multiple providers, receiving conflicting recommend ...
STTR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health