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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 1 - 10 of 8568 results
  1. HBI-002 to Prevent Vaso-Occlusive Crises in Sickle Cell Disease

    SBC: Hillhurst Biopharmaceuticals, Inc.            Topic: NHLBI

    PROJECT SUMMARY/ABSTRACT The goal of the proposed project is to evaluate the clinical potential of HBI-002, a novel oral low dose carbon monoxide (CO) drug product, that enables the use of low dose CO to prevent Vaso-Occlusive Crises (VOCs) in Sickle Cell Disease (SCD). Numerous studies, both preclinical and clinical, demonstrate that CO has dual mechanisms of action including anti-sickling and an ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Multi-Platform Homogeneous Multiplexed Autoantibody Assay Based on Liquid Micropiston-Enhanced Time-Resolved Forster Resonance Energy Transfer

    SBC: WAVE 80 BIOSCIENCES, INC.            Topic: 200

    Project Summary Detection and quantitation of autoantibodies is increasingly prioritized for diagnosis and management of type 1 diabetes (T1D). Assay methods and systems that can achieve clinically relevant performance in detecting and quantitating T1D-relevant autoantibodies—from the standpoint of key performance parameters such as sensitivity, specificity, reproducibility, and quantitative acc ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Genetic adjuvants to elicit neutralizing antibodies against HIV

    SBC: TENDEL THERAPIES INC            Topic: 105

    This project will test the ability of T follicular helper (Tfh) cell-targeting “genetic adjuvants” to improve immunogenicity of an advanced HIV envelope (Env) trimer. Eliciting neutralizing antibodies (nAb) against HIV will likely be required to create effective therapeutic vaccines that attenuate HIV disease progression, reduce HIV infectiousness, or even effect sustained remission in the abs ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. The Neurospan Bridge: A Device for Peripheral Nerve Repair

    SBC: AUXILIUM BIOTECHNOLOGIES INC.            Topic: NINDS

    Peripheral Nerve Injury (PNI) occurs in 3% of all trauma cases and 30% of combat injuries to the extremities, resulting in a loss of five million working days each year and costs of $150 billion annually in the U.S. The standard of care in the clinic is a nerve autograft from the patients’ leg. The NeuroSpan Bridge is a unique, biomimetic, multi-channel scaffold that maintains linearity througho ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. A silicon nanopore membrane blood filter enabling anticoagulant free continuous renal replacement therapy for acute kidney injury

    SBC: Silicon Kidney            Topic: 400

    Project Summary Acute Kidney Injury (AKI) commonly occurs in critically ill patients in the ICU. Patients with severe AKI often require continuous renal replacement therapy (CRRT) because it enables hemodynamic stability and better volume control. Anticoagulation therapy is frequently used to keep the CRRT circuit (especially the blood filter) from clotting as many critically ill patients are prot ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Novel peptide for enhancing diabetic wound healing

    SBC: SCARLESS LABORATORIES INC            Topic: 200

    PROJECT SUMMARY/ABSTRACT Diabetes Mellitus (DM), a metabolic disorder characterized by defective insulin signaling and elevated blood glucose, has become a public health epidemic with half of the US population diagnosed with either DM or pre- diabetes. One of the most common and devastating sequelae of uncontrolled DM is the development of chronic non-healing wounds. An estimated 25% of diabetic p ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a SYF2 antisense oligonucleotide treatment for ALS and FTD

    SBC: ACURASTEM INC            Topic: NIA

    Development of a SYF2 antisense oligonucleotide treatment for ALS and FTD Project Summary Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are complex diseases that result from many diverse genetic etiologies. Although therapeutic strategies that target specific causal mutations (e.g. C9ORF72 antisense oligonucleotides (ASOs)) may prove effective against individual forms of AL ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Rapid and high-contrast photothermal microscopy with a novel tunable ZGP source

    SBC: TRESTLE OPTICS LLC            Topic: 400

    Abstract. Natural products offer excellent sources of health-promoting medicines yet challenges in efficiently and economically sourcing these value-add bio-compounds have prevented their greater availability and promotion to public health. We address this problem by developing a novel image-based screening technology that offers highly sensitive, phenotypic bioassays of metabolite concentrations ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Ultra-broadband multimodal microscopy with a catadioptric lens

    SBC: TRESTLE OPTICS LLC            Topic: 400

    Abstract. Virtually all optical microscopes for biological imaging are based on refractive objective lenses. The performance of these lenses approaches the theoretical limit, however, their use is limited to the visible to near-infrared spectral range. Even within this range, their performance is only guaranteed over a relatively narrow range, and broadband use is invariably affected by chromatic ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. MagPAD: Magnetic Puncture, Access, and Delivery of Large Bore Devices to the Heart Via the Venous System

    SBC: MaGPaD, LLC            Topic: NHLBI

    Project Summary Minimally invasive cardio-thoracic approaches, such as transcatheter aortic valve replacement (TAVR), have recently overtaken traditional surgical methods due to significant reductions in procedural mortality, morbidity, and improved time to recovery. Transfemoral access of the heart via the femoral artery is the most common approach for delivery of large bore devices such as heart ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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