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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Iridium-electrode inhaled Nitric Oxide generator for treatment of hypoxic respiratory failure in neonates

    SBC: Third Pole, Inc.            Topic: NHLBI

    ABSTRACT Funding is requested to support essential steps required to commercializePa medical device thatgenerates medical grade nitric oxideNOfrom airNO is a pulmonary vasodilator to treat hypoxic respiratoryfailureHRFin neonatesblue babiesand pulmonary hypertension in patients having cardiothoracic surgeryCTSThird Pole s value proposition is that availability of a tank less iridium electrode NO g ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. An Integrated CT-based Image-Guided Neurosurgical System

    SBC: Xoran Technologies LLC            Topic: 102

    An Integrated CT based Image Guided Neurosurgical System In this SBIR Phase IIb proposal Xoran intends to commercialize a compact and affordableyet highlyfunctionalsystem to provide real time image updates and navigation guidance in support of minimally invasive cranial and spinal neurosurgical proceduresThe effort builds on previously developed compact and portable flat panel Computed TomographyC ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Next generation in vivo miniature microscopes integrating dual-color imaging, 3D imaging, and optogenetic stimulation with a cloud-compatible data acquisition platform

    SBC: Inscopix, Inc.            Topic: 101

    Project Summary Our understanding of neuropsychiatric disorders is undergoing a paradigm shift away from simple models emphasizing neurotransmitter imbalance towards more sophisticated theories based on abnormalities in neural circuit functionThis is especially important for understanding disorders like Schizophrenia and PTSDwhich defy simple biochemical explanationsbut are now known to involve ab ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Assessment of Multiple Dose Administration ofGlucagon Receptor Blocker REMD477 in Type 1 Diabetes

    SBC: REMD Biotherapeutics Inc.            Topic: 200

    ABSTRACT Insulin remains the mainstay treatment for typediabetes mellitusT Dhoweverit is associated with chronic iatrogenic hyperinsulinemia and life threatening hypoglycemia eventsLong term insulin treatment is also associated with secondary hyperlipidemiaand a higher incidence of cardiovascular complicationswhich tend to be more severeIndeeddeath due to cardiovascular complications is three fold ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Computerized tests of cognitive decline in presymptomatic Alzheimer's disease

    SBC: NEUROBEHAVIORAL SYSTEMS, INC.            Topic: R

    Patients who develop Alzheimer s diseaseADshow performance declines in tests of episodic memoryexecutive functioningand attention more than a decade before symptoms become apparent to their physician or familyThe rate of this performance decline is the primary outcome measure in ongoing clinical trials evaluating interventions aimed at delaying AD onsetHowevercurrent clinical trials rely on measur ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Advancing a novel potent double anti-HCV nucleoside analog combination treatment for the OUD population to the clinic

    SBC: Riboscience LLC            Topic: NIDA

    Our goal is to develop an ultra short curative regimen for hepatitis C virusHCVinfection in OUD patientsHCV is a major co morbidity of many OUD patientsTreating their HCV reduces their subsequent IV drug useWhile currently available regimens can cure HCV in most patients inweekslonger in patients with advanced liver disease or drug resistance mutations that are more frequent in OUD patientswhen th ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Stream Dx: Point of Care Cellular Enabled IoT Communication Hub for Improved Diagnosis, Monitoring, and Post-Treatment Evaluation of LUTS

    SBC: STREAM DX, INC            Topic: 400

    PROJECT SUMMARYABSTRACTSTREAM DX Lower urinary tract symptomsLUTSis one of the most common medical problems among older menaffectingof men by the time they reachyears of age andby the time they reach the age ofLUTS is a progressive disease that has been shown to significantly increase the risk of depression and reduce quality of lifeEarly detectionintervention and active management is critical to ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. A scalable system for high-throughput and longitudinal electrophysiology in rodent brain research

    SBC: Spikegadgets LLC            Topic: 101

    Psychiatric disorders give rise to aberrant patterns of activity within the complex neural circuits of our brainsYetthe exact nature of these abnormal patterns is often unknown to developers of new treatmentsThe goal of this project is to enable circuit oriented research of neuropsychiatric diseases using rodent disease modelsThe long term objective is to catalyze the discovery of new therapeutic ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Implantable Peripheral Nerve Stimulator for Treatment of Phantom Limb Pain

    SBC: RIPPLE, LLC            Topic: 999

    Abstract Chronic phantom limb painPLPhas been reported to inflict as many asof people with amputationsPLP is described as feeling like burningtwistingitchingor pressure in part of the missing limbThese painful sensations have a substantial negative impact on quality of lifepeople who suffer PLP have high rates of depressiondifficulty sleepingregular absences from workdissociation with family frien ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Development of completely automated quality control procedures for 4 PET Imaging tracers that will increase production throughput and lead to expanded diversity of PET imaging available to patients.

    SBC: Trace-Ability, Inc.            Topic: 101

    Long term objective of this project is increased availability of Positron Emission TomographyPETimaging to patients across different disease areasThe approach focuses on eliminating complexity and quality risks associated with production of radioactive contrast agentsPET tracers relied upon in neurology and oncologyThe specific solution developed in this project is a platform that will afterwards ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health

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