Award Data

DESCRIPTION (provided by applicant): We propose an innovative microtechnology-enhanced surgical device that solves a significant therapeutic bottleneck in the treatment of lens cataract in children. As the leading cause of childhood blindness, lens cataract interferes with the optical performance of the eye and if untreated, results in lifelong deficits in visual perception. The first step in pedi ...

DESCRIPTION provided by applicant The objective of this grant proposal is to perform a clinical study which will allow the first foldable and injectable artificial cornea the KeraKlear to be used in the United States market for treatment of corneal blindness This device may be implanted through an incision size that is approximately th the size of the incision that is required for the mo ...

DESCRIPTION provided by applicant The objective of the proposed study is to develop a subcutaneous implant of risperidone which provides consistent therapeutic blood levels of the drug for months The benefits of such product include improved medication adherence the ability to withdraw the medication if needed due to treatment emergent Adverse Effects AEs fewer relapses and improved eff ...

DESCRIPTION provided by applicant Positron Emission Tomography PET is a molecular imaging modality that utilizes radiolabeled molecules andquot probesandquot to target and measure biological processes Basic scientists can use the same probes to examine cells and mice as they do in patients to visualize and characterize the biology of disease monitor its progression and evaluate therapeutic efficac ...

DESCRIPTION provided by applicant This proposed Phase I SBIR project will transfer RASL Seq a targeted sequencing technology developed in academia to a small business Xpress Inc and demonstrate feasibility for its commercialization as a platform for drug discovery and high throughput screening HTS The technology detects hundreds of RNA targets at once in cell lysates using oligo li ...

DESCRIPTION provided by applicant The Specific Aim of this Phase II SBIR grant application is to launch ClonoByteandquot a website and cloud based platform for the processing storage analysis comparison and visualization of immune signature data sets generated by deep sequencing of immune repertoires There is a rapidly growing demand for T cell receptor TCR and immunoglobulin Ig repertoire sequenc ...

DESCRIPTION provided by applicant High throughput Electrophysiological Purification Array HEPA for cell based therapies Abstract Patient specific reprogrammed somatic cells induced pluripotent stem cells or iPSCs have raised hope for revolutionary regenerative treatments for heart lung and blood diseases and drug development applications For example these iPS cells can be differentiated ...

DESCRIPTION provided by applicant Project Summary Accurate quantification of alcohol and drugs of abuse intoxication in emergency rooms ERs is an important screening step for a precise diagnosis and hence for prompt treatment Some severe emergencies such as traumatic head injury diabetes and stroke can be misdiagnosed in the absence of screening for alcohol and drug intoxication reliable ...

DESCRIPTION provided by applicant NanoNerve is developing a novel diametrically patterned nanofibrous dural substitute for rapid dura mater regeneration following neurosurgical procedures In the US alone neurosurgical procedures are performed annually that require patching of the dura mater to prevent leakage infection and neural damage Currently available dural substitutes include xenogenic colla ...

DESCRIPTION provided by applicant Chronic gingival inflammation of the soft tissue surrounding the tooth afflicts over half of all American adults In the most severely affected progression of this inflammatory process to the deeper periodontal ligaments and alveolar bone results in tooth loss from loss of mandibular anchorage Gingivitis and periodontitis are initiated by chronic infection o ...