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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 377: Symptom Management and Intervention Roadmaps (STaIRS)

    SBC: Carevive Systems, Inc.            Topic: NCI

    Numerous adverse symptoms are under-detected in cancer care resulting1-3 in missed opportunities for intervention; leading to poor treatment adherence, avoidable hospitalizations, and worse morbidity and survival. The IOM proposed shaking up the current symptom paradigm from reactive to proactive, personalized, technology-enabled models of symptom care as a solution to this clinical quality crisis ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 375: 18F PET Tracer For Imaging PD-L1 (Moonshot)

    SBC: SIBTECH, INC.            Topic: NCI

    New therapies, designed to enhance anti-tumor immunity are based on the blockade of the checkpoint components, either PD-1 on immune cells or PD-L1 on tumor cells. This strategy, while being spectacularly successful in some patients for some cancers, fails for many other patients. The expression of PD-L1 is highly dynamic and its prevalence within tumors can vary significantly over time. The curre ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Development of “Permit Wizard” Software for AssistedPermit Application Completion

    SBC: Total Quality Systems, Inc.            Topic: 833

    TECHNICAL ABSTRACT: The objective of this project is to research the technical feasibility of designing a software tool “Permit Wizard” that will automate the process for aquamarine permit application submittal, review, approval/disapproval and issue (including collection of fees). Aquaculture producers are currently faced with slow, complex, and often confusing permitting processes that must ...

    SBIR Phase I 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  4. HQ-55 VTOL UAS for Ship Based Operation

    SBC: Latitude Engineering, LLC            Topic: 832

    TECHNICAL ABSTRACT: The Hybrid Quadrotor concept, developed by Latitude Engineering, combines the high power density of electric motors and propellers with the high energy density of a piston engine and liquid fuel. Together, each technology enables maximum performance in HQ's two regimes of flight: the electric system is responsible for lift while hovering (high power, short endurance), and the g ...

    SBIR Phase II 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  5. Randomized Prospective Phase II Clinical Trial of NVX in Association with Chemoradiation of Glioblastoma

    SBC: NUVOX PHARMA, L.L.C.            Topic: 102

    Glioblastoma multiforme GBM is a malignant primary brain tumor affecting about new cases per year in the U S Average survival is only about months Radiation RT is most commonly administered as fractions of Gray each over weeks with concomitant temozolomide TMZ GBM tumors are hypoxic The primary mechanism of RT is creation of singlet oxygen hypoxia within GBM adversel ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A novel biomaterial based therapy utilizing auto antigen and adjuvant for the amelioration of Type Diabetes

    SBC: ONEVAX, LLC            Topic: NIAID

    Immune mediated diseases such as type diabetes T D multiple sclerosis rheumatoid arthritis and systemic lupus erythematosis are reaching epidemic proportions in the US T D affects an estimated million Americans with more than new patients diagnosed annually resulting in roughly $ B in health care costs in the US each year T D is an autoimmune disease characterized by effector ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A Rapid Low Cost Point of Care Diagnostic for detection of Zika virus RNA

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    ABSTRACT Zika virus ZIKV has rapidly emerged and spread through South and Central America the Caribbean and Puerto Rico since its last outbreak in Micronesia in Transmitted by the mosquito Aedes sp its forecasted spread will have a major impact on the Southeast U S Most ZIKV infections remain asymptomatic or present with non specific rash and fever therefore they have been difficult ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. An interactive App to Promote Safe and Effective use of Opioids in Young Children Postoperatively

    SBC: ARCHIE MD INC.            Topic: NIDA

    In recent years increased attention to pain in children and adolescents has led to a recent fold increase in opioid prescriptions Unsurprisingly the annual rates of analgesic related adverse drug events AR ADEs have soared to include andgt hospital admissions and hundreds of accidental overdose deaths in children and adolescents and has remained a significant problem At the heart of ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Biomaterial based delivery of Interleukin to Regulatory T Cells for the amelioration of Type Diabetes

    SBC: ONEVAX, LLC            Topic: NIAID

    Type Diabetes T D results from a breakdown of self tolerance that is characterized by immune cell mediated destruction of the insulin producing cells in the pancreas Ultimately glucose metabolism is interrupted resulting in the development of life threatening complications such as heart disease and renal failure T D affects an estimated million Americans with more than new patie ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. High throughput multiplexed characterization and modeling of antibody antigen binding with application to HSV

    SBC: Carterra, Inc.            Topic: NIAID

    Abstract All therapeutic antibodies and most vaccines critically depend on the ability of antibodies to specifically recognize particular antigens consequently detailed characterization of antibody antigen binding can provide invaluable information to understand and guide development Unfortunately due to the time and expense required atomic resolution structure determination is typically use ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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