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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 375: 18F PET Tracer For Imaging PD-L1 (Moonshot)

    SBC: SIBTECH, INC.            Topic: NCI

    New therapies, designed to enhance anti-tumor immunity are based on the blockade of the checkpoint components, either PD-1 on immune cells or PD-L1 on tumor cells. This strategy, while being spectacularly successful in some patients for some cancers, fails for many other patients. The expression of PD-L1 is highly dynamic and its prevalence within tumors can vary significantly over time. The curre ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 375: Novel Diagnostic Imaging Modality for Monitoring Tumor Responses to a Hyperthermia Immunotherapy (Moonshot)

    SBC: Imago Systems, Inc.            Topic: NCI

    Immunotherapies have been emerging in the past decades as powerful approaches for cancer treatment. However, the immune system is complex, and therapy efficacy is substantially affected by the tumor microenvironment. For this reason, it is currently difficult to visualize tumor response and predict therapeutic efficacy. In this Contract, Imago Systems, Inc., a company with substantial experience i ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Analytical Tools and Approaches for (Multidimensional) Scholarly Research Assessment and Decision Support in the Biomedical Enterprise

    SBC: NET ESOLUTIONS CORPORATION            Topic: NIDA

    NIHthrough NIDAseeks advanced tools that could be broadly used by the life science community and generate results that would be understood by non scientists as well as professional evaluatorsIn Phase Ithe Contractor completed initial development of ERNIEan accessible big data platform integrating multiple data sources and associated methods for quantitative description of research that would facil ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. To develop a nanoSPRi sparing assay.

    SBC: Luna Innovations Incorporated            Topic: NIAID

    Proposes to develop a novelstandardized immune assay that improves monitoring of several biomarkerscytokinesassociated with immunologic pathways of AD with the constraint of having a limited amount of biological samplesThis overall goal is supported by the following program objectivesPhase IDemonstrate proof of concept of nanoSPRiSAas a sensitive and efficient technique in assessing cytokines in h ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. The objective of this contract is to develop a novel LBL RNA vaccine that can be administered to induce long-lasting protection against HIV challenge.

    SBC: Luna Innovations Incorporated            Topic: NIAID

    Extensive efforts have gone towards safe and effective vaccines for Human Immunodeficiency VirusHIVprevention and treatmentAlthough many strategies have been attempted for HIV vaccine developmentnone have been successfully establishedOne category of vaccines gaining increased popularity is RNA based vaccineswhich are vaccines containing antigens encoded by RNA and can be delivered by viral or usin ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Innovative Oral Formulations for Anti-Tb Drugs

    SBC: Luna Innovations Incorporated            Topic: NIAID

    The overall objective of this Phase II work plan is to develop a WHO certified fixed dose combinationFDCtroche for treatment of pediatric tuberculosisThis SBIR Phasecontract seeks to finalize development of a fixed dose combinationFDCAnti TB formulation that is stable under ambient conditions foryears and palatable to childrenThe goal of this project is to develop an innovative oral formulation fo ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Under Keel Clearance Management in Support ofPrecision Navigation

    SBC: W R SYSTEMS LTD.            Topic: 828

    TECHNICAL ABSTRACT: WR’s approach involves design of a modular, S-129 compliant Under Keel Clearance - Risk Management System (UKC-RMS). This will allow for the Electronic Chart Display and Information System (ECDIS), ECS, PPUs, and other situational awareness applications to have S-129 Exchange Sets developed for a planned route.In WR’s design, a system such as an ECDIS generates an S40X Rout ...

    SBIR Phase I 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  8. Development of “Permit Wizard” Software for AssistedPermit Application Completion

    SBC: Total Quality Systems, Inc.            Topic: 833

    TECHNICAL ABSTRACT: The objective of this project is to research the technical feasibility of designing a software tool “Permit Wizard” that will automate the process for aquamarine permit application submittal, review, approval/disapproval and issue (including collection of fees). Aquaculture producers are currently faced with slow, complex, and often confusing permitting processes that must ...

    SBIR Phase I 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  9. A Tube-Deployed Expendable UAV for AtmosphericSensing

    SBC: BARRON ASSOCIATES, INC.            Topic: 8213

    TECHNICAL ABSTRACT: NOAA is pursuing sustained, in-situ sensing technology to support improved atmospheric modeling of the upper ocean boundary environment, including the air-sea interface, during turbulent storms. Improved atmospheric modeling in this critical region will lead to better forecasting and support NOAA's mandate to protect property and save lives. Small, unmanned aircraft, equipped w ...

    SBIR Phase I 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  10. "Big Eye" Binoculars Extension Kit for Automating Bearing/Range Measurement and Image Storage

    SBC: R3 Digital Sciences, Inc.            Topic: 823

    TECHNICAL ABSTRACT: R3 Digital Sciences, Inc. (R3-DS) proposes to develop and commercialize an extension kit for "Big-Eye" and other binoculars that will automatically compute and store distance and bearing assessments by combining vertical reticle and stereoscopy measurement with motion analysis techniques. It will also capture and store photographic and video evidence of what the observer sees t ...

    SBIR Phase I 2018 Department of CommerceNational Oceanic and Atmospheric Administration

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