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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Phosphodiesterase-4B (PDE4B) Inhibitors for Alzheimer's Disease

    SBC: Tetra Discovery Partners, Inc.            Topic: 101

    Under the parent grantTetra Discovery Partners is developing phosphodiesteraseBPDE Ballosteric inhibitors as a treatment for major depressive disorderUniquelythe Tetra drug will address inflammation as a contributor to depressionThis is a new mechanism of action for an antidepressant drug which should prove complimentary to current therapeuticsThe company estimates thatof patients with depression ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Dual-view endoscopic probe

    SBC: Omniscient Imaging, Inc.            Topic: 102

    DESCRIPTION provided by applicant Colon cancer is a leading cause of cancer death in the United States and overseas Colonoscopy is the preferred screening method at an estimated annual cost of over $ billion in the US Unfortunately many lesions are missed because pre cancerous growths remain hidden from view behind folds and flexures of the colon Current methods of increasing the field of ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Small molecule inhibitors targeting oncogenic drivers of hepatocellular carcinoma

    SBC: L2 DIAGNOSTICS LLC            Topic: 102

    DESCRIPTION provided by applicant Hepatocellular carcinoma HCC is the most prevalent cancer in human population and will lead to over deaths in the United States this year alone However the molecular mechanisms driving hepatocellular carcinoma HCC growth and metastasis remain elusive and there is a huge unmet medical need to find new therapeutic targets We performed an unbiased ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Pancreatic Ductal Adenocarcinoma Targeted Ultrasound Contrast Agent Development

    SBC: NUVOX PHARMA, L.L.C.            Topic: 394

    DESCRIPTION provided by applicant Pancreatic ductal adenocarcinoma PDAC is a deadly form of cancer and patient survival depends upon the stage of diagnosis While overall survival at diagnosis is only about months of patients with stage I disease survive years The best currently available diagnostic test which is routinely performed in patients at high risk for PDAC is endoscop ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. PlusOne: Prototyping and Validation of a Wireless In-Home Breathing Monitor for Prevention of Overdose Deaths

    SBC: Xandem Technology LLC            Topic: NIDA

    DESCRIPTION provided by applicant This proposal investigates the use of a novel passive personal monitoring system to stem the tide in the epidemic of deaths due to unintentional opioid drug overdoses In the U S in opioid drug overdoses including prescription pain relievers and heroin caused deaths a number that has increased dramatically over the past two decades A person w ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Development of nucleic acid delivery platform based on polymeric CXCR4 antagonists

    SBC: Bohemica Pharmaceuticals, LLC            Topic: 100

    DESCRIPTION provided by applicant Therapeutics based on nucleic acids NA promise to revolutionize treatment of multiple diseases but their widespread use is currently limited by the lack of efficient delivery methods We have recently developed a new NA delivery platform based on polymeric CXCR inhibitors PCX suitable as dual function systems for simultaneous NA delivery and inhibition of ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Mutation Enriched Targeted Re Sequencing

    SBC: TRANSGENOMIC, INC.            Topic: 103

    DESCRIPTION provided by applicant Low level tumor associated somatic DNA mutations can have profound implications for development of metastasis prognosis choice of treatment follow up or early cancer detection Unless they are effectively detected these low level mutations can misinform patient management decisions or become missed opportunities for personalized medicine Widely used tech ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Simultaneous kinetic analyses of neuronal connectivities

    SBC: CIENCIA INC            Topic: 101

    DESCRIPTION provided by applicant Aberrant neuronal connectivity is associated with a number of neuropathological and neuropsychiatric diseases disorders Inefficient developmental connectivity misdirected connectivity or disrupted and degenerated connectivity can account for losses of normal neuronal communication and subsequent losses of mental or physical health Altered expression of axon ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Single-Molecule Analyte Detection by Molecular Motor-driven Nanodevices

    SBC: Attometrics            Topic: NIGMS

    DESCRIPTION provided by applicant There is an urgent need for a platform technology that can monitor changes in metabolite and protein biomarkers below current detection limits because in many cases the disease has progressed to an advanced state by the time the abundance of the biomarker has become measurable Our molecular motor powered nanodevice linked immunosorbent assay MONA LISA is ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Clinical Text Automatic De-Identification to Support Large Scale Data Reuse and Sharing

    SBC: Clinacuity, Inc            Topic: 400

    DESCRIPTION provided by applicant The adoption of Electronic Health Record EHR systems is growing at a fast pace in the U S and this growth results in very large quantities of patient clinical data becoming available in electronic format with tremendous potentials but also equally growing concern for patient confidentiality breaches Secondary use of clinical data is essential to fulfill ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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