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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 364: SysMet: Integrative Systems Metabolomics

    SBC: OmicsCraft LLC            Topic: NCI

    Metabolomics plays an indispensable role in the growing systems biology approaches to identify reliable cancer biomarkers. Liquid chromatography coupled to mass spectrometry (LC-MS) and gas chromatography coupled to mass spectrometry (GC-MS) have been extensively used for high-throughput comparison of the levels of thousands of metabolites among biological samples. However, the potential values of ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 375: 18F PET Tracer For Imaging PD-L1 (Moonshot)

    SBC: SIBTECH, INC.            Topic: NCI

    New therapies, designed to enhance anti-tumor immunity are based on the blockade of the checkpoint components, either PD-1 on immune cells or PD-L1 on tumor cells. This strategy, while being spectacularly successful in some patients for some cancers, fails for many other patients. The expression of PD-L1 is highly dynamic and its prevalence within tumors can vary significantly over time. The curre ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Development of “Permit Wizard” Software for AssistedPermit Application Completion

    SBC: Total Quality Systems, Inc.            Topic: 833

    TECHNICAL ABSTRACT: The objective of this project is to research the technical feasibility of designing a software tool “Permit Wizard” that will automate the process for aquamarine permit application submittal, review, approval/disapproval and issue (including collection of fees). Aquaculture producers are currently faced with slow, complex, and often confusing permitting processes that must ...

    SBIR Phase I 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  4. HQ-55 VTOL UAS for Ship Based Operation

    SBC: Latitude Engineering, LLC            Topic: 832

    TECHNICAL ABSTRACT: The Hybrid Quadrotor concept, developed by Latitude Engineering, combines the high power density of electric motors and propellers with the high energy density of a piston engine and liquid fuel. Together, each technology enables maximum performance in HQ's two regimes of flight: the electric system is responsible for lift while hovering (high power, short endurance), and the g ...

    SBIR Phase II 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  5. Randomized Prospective Phase II Clinical Trial of NVX in Association with Chemoradiation of Glioblastoma

    SBC: NUVOX PHARMA, L.L.C.            Topic: 102

    Glioblastoma multiforme GBM is a malignant primary brain tumor affecting about new cases per year in the U S Average survival is only about months Radiation RT is most commonly administered as fractions of Gray each over weeks with concomitant temozolomide TMZ GBM tumors are hypoxic The primary mechanism of RT is creation of singlet oxygen hypoxia within GBM adversel ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A user friendly point of care device for G PDH determination

    SBC: ANALYTICAL DIAGNOSTICS SOLUTIONS            Topic: NIAID

    Malaria caused by Plasmodium vivax threatens over billion people globally and sickens tens of millions annually Radical cure for P vivax malaria includes therapy aimed both at the acute attack blood schizontocidal and against future attacks hypnozoitocidal The only hypnozoitocide available are aminoquinolines such as primaquine or tafenoquine However clinicians often do not prescribe ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A Rapid Low Cost Point of Care Diagnostic for detection of Zika virus RNA

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    ABSTRACT Zika virus ZIKV has rapidly emerged and spread through South and Central America the Caribbean and Puerto Rico since its last outbreak in Micronesia in Transmitted by the mosquito Aedes sp its forecasted spread will have a major impact on the Southeast U S Most ZIKV infections remain asymptomatic or present with non specific rash and fever therefore they have been difficult ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Interstitial Intensity Modulated Photodynamic Therapy i IMPDT

    SBC: SIMPHOTEK, INC.            Topic: 102

    Over worldwide cases of head and neck Handamp N cancer occur annually Despite aggressive treatment about of Handamp N cancers recur and progress Recent studies of interstitial PDT I PDT have shown promising results in the treatment of patients with locally advanced Handamp N cancer that fail standard therapies I PDT provides a means to treat cancerous tumors while minimizing da ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Improved cleaning technology for reducing risk of transmitting infection in endoscopy

    SBC: ADVANCED BIODEVICES, LLC            Topic: NIAID

    Project Summary Abstract More than million procedures were performed with GI endoscopic devices in Since endoscopes cannot be sterilized risk of infection from contaminated endoscopes can be tangible and needs to be urgently addressed Infection at endoscopy has recently been recognized as a significant risk after two patient deaths from CRE infection transmitted by contaminated duodenos ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. High throughput multiplexed characterization and modeling of antibody antigen binding with application to HSV

    SBC: Carterra, Inc.            Topic: NIAID

    Abstract All therapeutic antibodies and most vaccines critically depend on the ability of antibodies to specifically recognize particular antigens consequently detailed characterization of antibody antigen binding can provide invaluable information to understand and guide development Unfortunately due to the time and expense required atomic resolution structure determination is typically use ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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