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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Systems- Agent Design Environment (Sys-ADE)

    SBC: 21ST CENTURY SYSTEMS, INC.            Topic: DTRA101001

    Irregular warfare emphasizes humanitarian efforts as part of “winning the hearts and minds.” Unfortunately, non-government organizations (NGOs) that work on humanitarian efforts tend to be non-technical or not prepared to merge with military standards. The result is inefficient operations and ineffective humanitarian actions. 21st Century Systems, Incorporated is pleased to introduce a Softwar ...

    SBIR Phase I 2010 Department of DefenseDefense Threat Reduction Agency
  2. Intravascular Cardiac Assist System for Decompression and Recovery

    SBC: ABIOMED, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): The objective of this proposal is to develop a less invasive long-term copulsation device to treat patients in late Class III and early Class IV stages of heart failure (HF). Chronic congestive heart failure is the largest unsolved problem in cardiac care today. There are over 5.5 million people in the United States with this diagnosis and the number of patient ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel Polymeric Percutaneous Heart Valve Prosthesis

    SBC: ABIOMED, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): The objective of this SBIR program is the modification of a polymeric trileaflet heart valve to a valve prosthesis that can be delivered percutaneously as a transcatheter aortic valve replacement. Key innovations include improved durability and hemodynamic properties, lower manufacturing costs, and simplified delivery over existing transcatheter bioprosthetic v ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  4. Minimally Invasive Pediatric VAD for Treatment of Acute Heart Failure

    SBC: ABIOMED, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): The overall objective of this proposed program is the commercialization of the Pediatric Impella system, a minimally invasive ventricular assist device (VAD) for treatment of acute heart failure in pediatric patients. The device will be a less traumatic alternative to extracorporeal membrane oxygenation (ECMO), the current standard of care for these patients. T ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  5. Novel Antibacterial Agents That Target DNA Replication in Mycobacterium tuberculo

    SBC: Achillion Pharmaceuticals, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): Mycobacterium tuberculosis (MTB) is probably the most ubiquitous microbial pathogen in the world today infecting one-third of the total population and causing millions of active tuberculosis (TB) cases each year. The economic costs are substantial and more than one million people die of TB infections each year. Before the arrival of antimicrobial therapy, TB wa ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a method to multiplex ChIP-SEQ and ChIP-chip experiments

    SBC: AFFOMIX, INC.            Topic: NHGRI

    DESCRIPTION (provided by applicant): The immediate objective of our research is to generate a method that will enable researchers to multiplex Chromatin ImmunoPreciptation-Sequencing (ChIP-Seq) analysis in a single Next generation DNA sequencing run. In the to-be-developed method: i) a set of antibodies directed against specific DNA-binding proteins are uniquely bar-coded with a DNA 'ZipCode;' ii) ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  7. High-throughput screening and identification of scFv antibodies against glycosyla

    SBC: AFFOMIX, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): The specific goal of this proposal is to develop a high-throughput method to identify scFv antibodies that recognize post-translationally modified proteins. We propose to complete a proof-of-concept for a new type of affinity screening process based on emulsion, secretion, and capture, which we term ESCape . In the proposed phage ESCape method, E. coli transfo ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  8. A bifunctional antibody screening system for both phage display and yeast two-hyb

    SBC: AFFOMIX, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): This is a proposal to establish a proof-of-principle for a vector system to isolate high-affinty antibodies through selective rounds in both yeast and Escherichia coli. Antibodies have quickly become extremely useful as therapeutic medicines to treat a wide-variety of disorders. We propose to develop a means of making the discovery of immunotherapeutics faster ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  9. Compact Chemical Sensor for Measurement of Internal Dose of Environmental Agents

    SBC: AGILTRON, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): Detection of exposure to environmental agents by measurement of internal dose of such agents or their metabolites, chemical or biological, requires rapid assessment and identification of exposure to both known and unknown threats. Fast detection and identification of exposure to such threats can provide prompt warning of the extent and severity of the exposure ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  10. High Performance Detectors for SPECT

    SBC: RADIATION MONITORING DEVICES, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): High Performance Detectors for SPECT P.I.: Dr. Michael R. Squillante Abstract Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the three dimensional distribution of a radionuclide throughout the body of a human patient or a research animal. Typically, the collected data are d ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
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