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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 343- Cognitive Assessment and Monitoring Platform For Integrative Research (CAMPFIRE II)

    SBC: Charles River Analytics, Inc.            Topic: NCI

    Cancer survivors commonly report cognitive impairments following chemotherapy. With a growing number of cancer survivors comes an increased urgency to better understand the precise etiology and prevalence of cognitive changes associated with cancer and cancer treatment. This pursuit is impeded by a lack of assessment tools that can accurately detect the full scope of cognitive deficits. To address ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. The purpose of this contract is to develop an assay to detect minor populations of resistant variants in blood specimens from HIV-infected individuals with HIV RNA viral loads above 1000 copies/ml

    SBC: ALDATU BIOSCIENCES, INC.            Topic: NIAID

    Antiretroviral therapyARTreduces mortality and morbidity in HIV infected individualsbut specific HIV mutationsDRMsare associated with resistanceIt is now known that certain DRMs can contribute to virological failure even at very low concentrationsbut standard tests are inadequately sensitive to detect these minor variantsMethods to detect minor variants that contribute to HIV virological failure a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. SBIR TOPIC 096:Novel Biodegradable Stents for Neonatal Aortic Coarctation

    SBC: 480 Biomedical Inc.            Topic: NHLBI

    Aortic coarctation is a common congenital heart condition that is usually recognized during the neonatal period early after birth The usual treatment is open surgery Non surgical catheter based stent therapy is not available to treat neonatal aortic coarctation because children outgrow commercially available metallic stents Absorbable stents might revolutionize the treatment of aortic coarctation ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Automated peak fitting and analysis software for advanced gas chromatography and mass spectrometer systems

    SBC: Aerodyne Research, Inc.            Topic: 827

    TECHNICAL ABSTRACT: Recent advances in gas chromatographic (GC) and mass spectrometric (MS) techniques for atmospheric measurements have led to highly complex data sets that have overwhelmed the capabilities of current data analysis software. We propose a new method for the automated reduction of chromatographic data using peak-fitting algorithms. By relying upon constrained peak-fit parameterizat ...

    SBIR Phase II 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  5. Development of a Portable 3-dimensional Variational (3DVAR) Data Assimilation Module for NOAA Operational Forecasting Systems

    SBC: REMOTE SENSING SOLUTIONS, INC.            Topic: 814

    TECHNICAL ABSTRACT: We propose to continue the development of a generalized 3DVAR data assimilation module, in an open-source and non-proprietary programming language, which is compatible with FVCOM and incorporated into the Lake Erie Operational Forecast System (LEOFS). We will leverage our experience and expertise in using 3DVAR for a ROMS-based real-time forecast system for the California coast ...

    SBIR Phase II 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  6. HQ-55 VTOL UAS for Ship Based Operation

    SBC: Latitude Engineering, LLC            Topic: 832

    TECHNICAL ABSTRACT: The Hybrid Quadrotor concept, developed by Latitude Engineering, combines the high power density of electric motors and propellers with the high energy density of a piston engine and liquid fuel. Together, each technology enables maximum performance in HQ's two regimes of flight: the electric system is responsible for lift while hovering (high power, short endurance), and the g ...

    SBIR Phase II 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  7. Automated HCl laser monitor for long term and flight deployments

    SBC: Aerodyne Research, Inc.            Topic: 813

    TECHNICAL ABSTRACT: Tropospheric oxidation capacity is dominated by HOx photochemistry, however halogen atoms and oxides significantly affect these chemical cycles. A sensitive and robust measurement of gaseous HCl is critically important to improve our understanding of halogen chemistry and its impacts on the spatial and temporal oxidation capacity of the atmosphere. In Phase I, we met all of our ...

    SBIR Phase II 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  8. Randomized Prospective Phase II Clinical Trial of NVX in Association with Chemoradiation of Glioblastoma

    SBC: NUVOX PHARMA, L.L.C.            Topic: 102

    Glioblastoma multiforme GBM is a malignant primary brain tumor affecting about new cases per year in the U S Average survival is only about months Radiation RT is most commonly administered as fractions of Gray each over weeks with concomitant temozolomide TMZ GBM tumors are hypoxic The primary mechanism of RT is creation of singlet oxygen hypoxia within GBM adversel ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. A novel immunotolerizing therapy for autoimmune vitiligo

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NIAMS

    Radikal Therapeutics RTX is developing a pioneering therapy to restore immunotolerance and arrest progressive depigmentation in vitiligo At our partnering institution Loyola University Chicago a variant to inducible Heat Shock Protein was developed with remarkable potential for the prevention and treatment of autoimmune vitiligo Carrying only a single amino acid modification to the protei ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Development of New Improved Perflutren Ultrasound Contrast Agent

    SBC: MICROVASCULAR THERAPEUTICS LLC            Topic: NHLBI

    Three ultrasound contrast agents Definity Optison and Lumason are FDA approved for echocardiography in the U S Definity currently has over market share Definity s dominance in the market is due to its ease of administration via IV infusion and robust ultrasound contrast Definity has shelf life of years and must be stored under refrigerated conditions Definity has an unpleasant ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health

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