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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Mutation Enriched Targeted Re Sequencing

    SBC: TRANSGENOMIC, INC.            Topic: 103

    DESCRIPTION provided by applicant Low level tumor associated somatic DNA mutations can have profound implications for development of metastasis prognosis choice of treatment follow up or early cancer detection Unless they are effectively detected these low level mutations can misinform patient management decisions or become missed opportunities for personalized medicine Widely used tech ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Developing Therapeutics That Target RAD To Treat Leukemia and Lymphoma

    SBC: Cyteir Therapeutics, Inc.            Topic: NCI

    DESCRIPTION provided by applicant Genomic instability is a hallmark of cancer and represents a targetable vulnerability yet is underdeveloped as a therapeutic area The central goal of this Phase program is to complete the early preclinical development of a new class of new cancer therapeutics that uniquely target RAD delivering effective cancer cell selective therapy in subsets of bioma ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. A NOVEL NEUROPROTECTIVE THERAPY FOR ALZHEIMER'S DISEASE

    SBC: Klogene Therapeutics, Inc.            Topic: NIA

    DESCRIPTION provided by applicant Alzheimerandapos s disease AD is one of the most significant public health problems of the st century with the number of patients in the US estimated to grow from million to million by and an annual cost of care projected to reach $ trillion Current treatments for AD have limited effect for a short duration and only serve to alleviate sympto ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Improving vaccine development through high throughput immunogenicity screening

    SBC: Carterra, Inc.            Topic: NIAID

    Abstract Vaccines are fundamental in preventing debilitating illnesses and saving millions of lives each year But despite these vaccine oriented victories infectious diseases are still the second leading cause of death as well as the leading cause of disability adjusted life years worldwide About six million deaths were attributed to AIDS malaria and tuberculosis in regions where no vaccine ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. FAST TRACK IND Enabling Studies for Oral Cancer

    SBC: PRIVO TECHNOLOGIES, LLC            Topic: 102

    DESCRIPTION provided by applicant According to the Oral Cancer OC Foundation oral and pharyngeal cancer will cause deaths this year in the US killing roughly one person per hour Currently cisplatin CIS is at the forefront of platinum based chemotherapeutics for treating OC However its efficacy is often hindered by its significant systemic toxicity as a resut of traditional bolus ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Novel Androgen Receptor Degraders to Treat Castration Resistant Prostate Cancer

    SBC: Arvinas, Inc            Topic: 102

    DESCRIPTION provided by applicant The overall aim of this grant is to generate data to understand and enable the development of a novel therapeutic approach for the treatment of patients with castration resistant prostate cancer Prostate cancer is the third most lethal cancer in the US with new cases and deaths projected to occur in While early detection surgery and horm ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Type Teamwork A tool for Parents of Adolescents with Type Diabetes

    SBC: New England Research Institutes, Inc.            Topic: 200

    DESCRIPTION provided by applicant Type diabetes T D is one of the most common chronic illnesses in children affecting in with evidence that its prevalence is increasing worldwide The prevalence of T D in adolescents is approximately percent White percent Hispanic and percent Black Parents of children with T D are responsible for a labor intensive and complicated dai ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Establishing In Vivo Proof of Concept of Brown Adipogenesis Using Approved Drugs

    SBC: ENERGESIS PHARMACEUTICALS, INC.            Topic: 200

    DESCRIPTION provided by applicant Obesity has reached epidemic proportions in the U S and plays a major role in the development of type diabetes dyslipidemia and cardiovascular disease There remains a very significant need for better non surgical treatments While most weight loss agents rely on suppressing appetite to reduce caloric intake strategies that can safely enhance energy expe ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Customized Nanotechnology Based Treatment of Oral Cancer

    SBC: PRIVO TECHNOLOGIES, LLC            Topic: NIDCR

    DESCRIPTION provided by applicant In this proposal Privo describes its research and development plans in order to obtain Food and Drug Administration FDA Investigational New Drug IND status for its localized nanoparticle based chemotherapy wafer for safely treating oral cancer According to the Oral Cancer Foundation over Americans will be diagnosed with oral and pharyngeal cancer ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  10. PEPTIDE BEAD MICROARRAYS MEASURED BY MASS SPECTROMETRY IMAGING

    SBC: ADEPTRIX CORP.            Topic: 400

    DESCRIPTION provided by applicant Mass spectrometry based proteomics currently lacks a robust technology for performing affinity separation in a multiplex format andapos s to andapos s of analytes which would be analogous to planar microarrays and suspension bead arrays on the fluorescence detection platforms Achieving better integration of affinity separation with mass spectrometry ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health

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