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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. SBIR TOPIC 108, FAST-TRACK- DEVICE SYSTEM FOR TRANSCATHETER REPAIR OF POSTINFARCTION VENTRICULAR SEPTAL DEFECT

    SBC: TRANSMURAL SYSTEMS LLC            Topic: NHLBI

    The goal of the project is to develop a device for percutaneous closure of postinfarction ventricular septal defectVSDin adultsFirst a prototype would be developed and tested in animalsand ultimately a clinical grade device would undergo regulatory developmentPhase I will include the development and testing of a postinfarction VSD occluder prototypePhase II will include mechanical and safety testi ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. SBIR TOPIC 106, FAST-TRACK- ACTIVE MRI NEEDLE

    SBC: TRANSMURAL SYSTEMS LLC            Topic: NHLBI

    Needle access to deep organs is common to numerous catheterradiologicaland surgical proceduresboth diagnostic and therapeuticincluding access to blood vesselspericardial and cardiac chambersvisceraetcMRI operation affords exquisite imaging and delineation of soft tissue beyond what is afforded by X ray fluoroscopyCTand ultrasound guidancePassiveneedles visualized solely by their material propertie ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. SBIR TOPIC 107, PHASE I- TRANSCATHETER POTTS SHUNT

    SBC: TRANSMURAL SYSTEMS LLC            Topic: NHLBI

    The goal of Phase I is to develop and test a Transcatheter Potts Shunt prototype system in vivoThe deliverable is a catheter system to establish a non surgical Potts Shunttranscatheter pulmonary to aortic anastomosisto treat refractory pulmonary artery hypertensionPhase I will focus on mechanical and biological performance of the proposed endografttaking into account mechanical strength required f ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Nanoparticle Delivery of HIV Env Trimer for Inducing Somatic Hypermutation and bNAb

    SBC: Anatagen Pharmaceuticals, Inc.            Topic: NIAID

    HIVthe virus that causes AIDSis one of the world s most serious health challengesAccording to UNAIDSthere were approximatelymillion people worldwide living with HIV AIDS at the end ofThe vast majority of them are in lowto middle income countriesparticularly in sub Saharan AfricaA low cost vaccine broadly neutralizing most strains of HIV is the preferred response to protect the human populationHowe ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Antibody Fragments to Improve HIV gp120 Protein Production

    SBC: Abzyme Therapeutics, LLC            Topic: NIAID

    Camelid single domain antibody fragmentsVHHpossess a number of distinctive features including a small sizean elevated stabilityand an ability to recognize epitopes non accessible for conventional antibodiesBesides common research and immunotherapy applicationscamelid VHHs are also used as co crystallization chaperonesprotein aggregation controllers and enzyme activity tunersIn this proposalwe wish ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Increased Expression of an HIV CJ505.664 SOSIP Envelope in Plants by Modulation of ER Chaperones

    SBC: Plant Vax, Inc.            Topic: NIAID

    The recombinant HIV SOSIP EnvelopeEnvtrimer is the leading HIV vaccine candidate but current production levels are low in mammalian cell lineslikely due to current trimer designs which include numerous disulfide bondsproteolytic cleavage and extensive glycosylationknown to induce endoplasmic reticulumERstress and cellular toxicityThis proposal will utilize the Nicotiana benthamiana pN bpplant expr ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A Smartphone-based point-of-care Sensor for Rapid and Sensitive Detection of Malaria in Low-Resource Applications

    SBC: Giner, Inc.            Topic: NIAID

    The wide availability of rapidfield portablelow costand sensitive molecular diagnostic for point of care detection of malaria parasites would have a significant benefit for intervention programs aimed at eliminating malaria in affected populationsMalaria remains one of the most serious infectious diseases in low income countriesthreatening nearly half of the world s population and causing an estim ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Development of Nanvas TM (Oil in Water Nanoemulsion Adjuvant) Formulated Allergens as Intranasal Immunotherapeutic Vaccines for Peanut Allergy

    SBC: Bluewillow Biologics, Inc.            Topic: NIAID

    Food allergy is an emerging health problem with increasing incidence and severityparticularly in childrenand continuing throughout adulthoodSincethe incidence of self reported peanut allergy has risen significantly representing a mounting financial burden to the healthcare systemWith no approved therapeutics availablevarious forms of immunotherapy have been evaluated but generally do not facilitat ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Novel Nano-emulsion Immuno-suppressive Adjuvant for Allergy Vaccines

    SBC: Epitogenesis, Inc.            Topic: NIAID

    Bronchial asthma is a chronic respiratory disease that can be lethalAsthma is a global health problemAccording to the CDCin USAthere are currentlymillion asthma sufferers and this number is increasingHalf of the asthma patients have at least one hospitalization per yearwith an annual medical cost of $BTraditionallyasthma is treated during flare ups with prescribed inhaled corticosteriodsIn recent ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. IGF::OT::IGF TOPIC 378: SYMPTOMATIC TOXICITY MOBILE MONITOR (SYMPTMM)

    SBC: Vivonics, Inc.            Topic: NCI

    The goal of this NIH Phase I SBIR proposal is to develop and validate a new method to monitor the symptomatic toxicities and health related quality of life of cancer patients who are undergoing and have undergone radiation therapy during the course of their treatmentThe proposal is built around expertise in mobile application developmentVivonics Incand radiation oncologyDrTJ Fitzgerald of the Univ ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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