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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Measuring toxicant effects on cellular function in a microarray format

    SBC: CIENCIA INC            Topic: 113

    Project Summary AbstractThe EPA maintains a Toxics Release Inventory of andgttoxic chemicals that are disposed or released from andgtindustrial sites in the United Stateswhile HHS and USDA maintain a list of overselect agents and toxicants that pose a severe risk to humananimaland plant healthThese compounds represent only a fraction of the known and unknown environmental toxicants that may advers ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Medications for Synthetic Cannabinoid Abuse

    SBC: PAFOSPharma, LLC            Topic: R41

    PROJECT SUMMARY ABSTRACT In response to PAthis Phase I STTR proposal will aim at developing pharmacotherapies that can act aslife savermedications to counteract the neurotoxic effects of synthetic cannabinoidsSCsTowards this goalwe will synthesize CB R antagonists with fast onsets of action that can be administered in an emergency roomERsituationThe rationale is based on the successful soft agonis ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Discovery of T-type Calcium Channel Antagonists from Multicomponent Reactions and Their Application in Paclitaxel-induced Peripheral Neuropathy

    SBC: Regulonix            Topic: 101

    Summary Abstract Chemotherapy induced peripheral neuropathyCIPNis detected inof cancer patients during all phases of cancerSensory symptoms in the hands and or feettypically in astocking glovepatternare commonand manifested as painnumbnessand or tinglingCIPN can result in chemotherapy dose reduction or discontinuationand can also have long term effects on the quality of lifeThe course of CIPN can ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. A novel vaccine against mosquito-borne Zika virus based on mosquito salivary gland protein AgBR1

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    PROJECT SUMMARYZika virusan emerging flavivirusis associated with severe clinical outcomesincluding Guillain Barrsyndrome and birth defectsTransmission of Zika virus is primarily mosquitoborneMosquito salivary proteins are known to enhance infectivity and pathogenesis in Zikadengue and West Nile viruses by modulating immune responsesThis proposal seeks to develop a novel vaccine against Zika virus ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Mechanical generation of peri-valvular oscillatory flow to prevent deep venous thrombosis.

    SBC: OsciFlex LLC            Topic: NHLBI

    Project SummaryDeep venous thrombosisDVTand secondary pulmonary embolismPEaffectof the population and cause approximatelydeaths annually in the USImmobility and lack of muscular activity is the primary risk factor for DVTan effect attributed to reduced venous flowAutopsy studies have identified the venous valve sinus in the leg as the site of origin for DVTbut a molecular and cellular mechanism fo ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Mitigation of Radiation Therapy Induced Neuroinflammation and Cognitive Dysfunction

    SBC: ImmunoChem Therapeutics, LLC            Topic: 102

    PROJECT SUMMARY Cognitive decline and deterioration of long term cognitive performance are major side effects of CNS cancer treatmentBrain metastases are the most common CNS malignancies and a common cause of morbidity and mortality in aboutof all cancer patients with systemic diseaseaffecting overpatients in the US annuallyAs most systemic chemotherapy agents do not cross the blood brain barriert ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a tracheal sound sensor for early detection of hypoventilation due to opioid overdose.

    SBC: RTM Vital Signs, LLC            Topic: R41

    Abstract More thanAmericans died from drug overdose inand drug overdose is now the most common cause of death for people underyears old in the United StatesFurthermorethe number of overdose deaths is increasing with the rise of abuse of powerful synthetic opioidssuch as fentanylIn May ofNational Institutes of HealthNIHand National Institute on Drug AbuseNIDAdirectors DrsCollins and Volkow outlined ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Discovering a Small Molecule that Targets the KSHV Processivity Factor for Treating Oral and Systemic Kaposi Sarcoma

    SBC: Fox Chase Chemical Diversity Center, Inc.            Topic: NIDCR

    Kaposi SarcomaKSis the most common cancer in themillion worldwide AIDS populationKS tumors are caused by Kaposi Sarcoma Associated Herpes VirusKSHVEven though HAART therapy has resulted in a dramatic decline in KS in the USthis malignancy remains the most predominant tumor of AIDSParadoxicallyKS tumors arise in some AIDS patients following HAART treatmentdue to Immune Reconstitution Inflammatory S ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Developing a Scalable Manufacturing Process for an Oral Bacteriophage Product that Prevents Cholera

    SBC: PhagePro, Inc.            Topic: NIAID

    PROJECT SUMMARY Cholera is an acute and severe disease caused by the bacterium Vibrio cholerae that is spread primarily through contaminated water sources due to a lack of adequate sanitation infrastructureThe World Health Organization estimates that there are at leastmillion cases globally per yearpercent of which are spread through household transmissionCurrent prevention methods require signifi ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Glioblastoma multiforme therapy via telomerase reverse transcriptase (hTERT) down-regulation. Molecular chaperones redirect quadruplex folding to reverse the effect of hTERT gene promoter mutations.

    SBC: Reglagene, LLC            Topic: 106

    Project Summary Overexpression of hTERT is a hallmark of cancer and is associated with oncogenesistumor maintenanceand resistance to conventional chemotherapyElongated telomeres at the ends of chromosomes are a hallmark for cancer in the early stage of tumorigenesis and are associated with genetic instabilityAs a consequencesuppressed telomerase in normal cells is highly activated to immortalize t ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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