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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Plasmodium Falciparum Whole Sporozoite Malaria Vaccine

    SBC: SANARIA INC.            Topic: NIAID

    DESCRIPTION provided by applicant The ideal tool for eliminating Plasmodium falciparum Pf the causative agent of of all malaria deaths would be a highly effective vaccine that prevents blood stage infection and thereby prevents the disease and transmission The only immunogens demonstrated in humans to be able to induce andgt protective efficacy that is sustained months are ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  2. Optimization of a DNA Subunit Regimen for an HIV Vaccine

    SBC: PROFECTUS BIOSCIENCES, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Our primary approach to develop an effective prophylactic vaccine against HIV utilizes a novel immunogen called the Full Length Single Chain FLSC that consists of gp derived from HIV BaL genetically linked via a amino acid linker to the D D domains of human CD Rhesus macaques were inoculated with rhFLSC a surrogate version of FLSC that contains CD derived from rhe ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  3. Preserving beta-lactam utility vs pathogens producing any class of beta-lactamase

    SBC: VenatoRx Pharmaceuticals, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Multi drug resistance in Enterobacteriaceae is regarded as a healthcare crisis This crisis has been further amplified by the recent emergence of the NDM andquot super bug geneandquot a zinc based metallo lactamase Amber Class B in Enterobacteriaceae Members of this family of resistance enzymes are found on promiscuous plasmids with other MDR resistance mechanisms ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  4. Plasmodium Falciparum Whole Sporozoite Malaria Vaccine

    SBC: SANARIA INC.            Topic: NIAID

    DESCRIPTION provided by applicant The ideal tool for eliminating Plasmodium falciparum Pf the causative agent of of all malaria deaths would be a highly effective vaccine that prevents blood stage infection and thereby prevents the disease and transmission The only immunogens demonstrated able to induce andgt sustained months protective efficacy in humans are Pf sporozoit ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  5. Therapeutic D-peptide Inhibitor of HIV Entry

    SBC: NAVIGEN, INC.            Topic: NIAID

    DESCRIPTION provided by applicant With million people living with HIV AIDS including million in the US and million AIDS related deaths annually HIV AIDS remains a formidable global epidemic UNAIDS CDC Modern HIV therapy combines drugs from different classes to form andquot cocktailandquot therapies that have significantly prolonged the lives of many HIV patients However side effects and drug resis ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  6. Phase II SBIR: Responding to NDM-1- Advancement of a new MBL inhibitor to IND

    SBC: VenatoRx Pharmaceuticals, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Multi drug resistance in Enterobacteriaceae is regarded as a healthcare crisis While carbapenems are among the most prescribed antibiotics for infections caused by these organisms carbapenem resistance conferred by zinc based metallo carbapenemases Amber Class B is a growing global health concern that threatens to erode the efficacy of these antibiotics both in th ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  7. Novel Antithrombotic Diadenosine Tetraphosphate Analogs

    SBC: GLSynthesis Inc.            Topic: 100

    DESCRIPTION Undesired platelet activation can be result of many common pathologies or interventions Arterial thrombosis and the acute ischemic events that follow such as myocardial infarction and stroke are among the leading causes of death incapacitation and rising health care costs in the developed world Therefore antiplatelet drugs have significant market share and clinical importance ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  8. Low-Dose MRI-Compatible Molecular Breast Imaging Device

    SBC: Weinberg Medical Physics, Inc.            Topic: 102

    DESCRIPTION provided by applicant Contrast enhanced MRI has been proven to be a very sensitive modality for the early diagnosis of breast cancer in young women and or in women with radiographically dense breasts The American Cancer Society recommends that high risk women with lifetime risk greater than should receive annual breast MRI screening Depending on the practitioner and study char ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  9. Augmented Reality Head Mounted Display for Magnetic Resonance Imaging Guided Inte

    SBC: Robin Medical, Inc.            Topic: 102

    DESCRIPTION provided by applicant The broad long term objective is to develop a low cost easy to use system that can convert diagnostic MRI scanner into a functional neurosurgical MRI suite The specific aims of the project are Develop the display only mode of the HMD that integrates MRI realtime scans and device tracking annotation into a stereoscopic D display Feasibility of such HMD ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  10. DNA Repair-on-a-Chip: Spatially Encoded Microwell Arrays

    SBC: TREVIGEN, INC.            Topic: NIEHS

    DESCRIPTION provided by applicant Preserving genomic integrity is essential in order to suppress cancer neurodegeneration aging and other diseases At odds with genomic preservation is DNA damage which can drive mutations sequence rearrangements and cellular toxicity DNA damage is unavoidable as DNA damaging agents are present in our environment and in our cells To counteract the deleter ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health

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