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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Antibody targeting of ADAM for treatment of triple negative breast cancer

    SBC: Adecto Pharmaceuticals, Inc.            Topic: NCI

    DESCRIPTION provided by applicant Triple negative breast cancers TNBCs account for of breast cancer deaths and lack targeted therapies Drs Sonenshein Mineva and Romagnoli and their co workers recently identified the non essential cell surface protein ADAM A Disintegrin and Metalloprotease as a pivotal promoter of breast tumor growth and metastasis and validated it as a target o ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Mutation Enriched Targeted Re Sequencing

    SBC: TRANSGENOMIC, INC.            Topic: 103

    DESCRIPTION provided by applicant Low level tumor associated somatic DNA mutations can have profound implications for development of metastasis prognosis choice of treatment follow up or early cancer detection Unless they are effectively detected these low level mutations can misinform patient management decisions or become missed opportunities for personalized medicine Widely used tech ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Developing Therapeutics That Target RAD To Treat Leukemia and Lymphoma

    SBC: Cyteir Therapeutics, Inc.            Topic: NCI

    DESCRIPTION provided by applicant Genomic instability is a hallmark of cancer and represents a targetable vulnerability yet is underdeveloped as a therapeutic area The central goal of this Phase program is to complete the early preclinical development of a new class of new cancer therapeutics that uniquely target RAD delivering effective cancer cell selective therapy in subsets of bioma ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Natural product inspired antibacterials with unique ribosomal binding

    SBC: Curza Global, LLC            Topic: NIAID

    Project Summary The long term objective of this project is to develop a new class of broad spectrum antibiotics focused on Gram negative bacteria Inspired by a natural product this class targets an unexploited binding site of the bacterial ribosome With ever increasing reports of resistance to frontline therapies addressing Gram negatives there is a critical need for new therapies yet very ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Optimization of a mucosal RSV vaccine

    SBC: Biomedical Research Models, Inc.            Topic: NIAID

    Abstract Human respiratory syncytial virus RSV is a highly infectious member of the paramyxovirus family causing upper and lower respiratory tract infections RSV is the leading cause of pulmonary disease of the lower respiratory tract bronchiolitis pneumonia and respiratory failure in infants due to virus induced airway damage and complex inflammatory processes and responsible for an estima ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Novel Trypanocidal Compounds for the Treatment of Stage and HAT

    SBC: MEDISYNERGICS, LLC            Topic: R

    DESCRIPTION provided by applicant Human African Trypanosomiasis HAT is a disease caused by a parasitic organism trypanosoma brucei It is often referred to as andquot sleeping sicknessandquot because of the symptoms that emerge in Stage patients The disease exists in two forms depending on the causative parasite Trypanosoma brucei gambiense or Trypanosoma brucei rhodesiense T b gamb ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Novel beta lactams as inhibitors of ebola virus infections

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Ebola virus EBOV is a member of the filovirus family that causes severe viral hemorrhagic fever VHF Although infrequent epidemics of EBOV can cause high mortality rates of up to the subsequent medical and social upheaval can be widespread and severe as seen in the recent outbreak in Western Africa which has already caused more than fatalities ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Biopsy Probes with Real time Multi modality Image Guidance for Peripheral Lung Nodules

    SBC: LX Medical            Topic: NCI

    DESCRIPTION provided by applicant Recent technological advances have enabled low dose spiral CT to become an effective tool for lung cancer screening The majority of pulmonary nodules detected on CT however are small and difficult to diagnose While CT guided transthoracic needle biopsy CT TTNB has high diagnostic accuracy to depending on nodule size the risk of complications su ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Goldmann Contact Tonometry with Optimized Error Correction

    SBC: INTUOR TECHNOLOGIES LLC            Topic: N

    DESCRIPTION provided by applicant Intraocular pressure IOP is arguably the second most important criteria used to assess visual acuity when eye care professionals are diagnosing treating and managing patients The patented Intuor Applanation Tonometer IAT prism design is a novel and simple approach for improving the accuracy of IOP measurement in the eye The proposal describes an inexpen ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Development Of Novel Diabetes Therapies Based On Neutralizing FSTL3 Activity

    SBC: Fairbanks Pharmaceuticals Inc            Topic: 200

    DESCRIPTION provided by applicant Both type and type diabetes involve loss of insulin producing pancreatic cells resulting in inadequate insulin secretion to control blood glucose Eventually daily injections of insulin are required to avoid the constellation of pathologies that arise from hyperglycemia While transplantation of cadaveric pancreatic islets that contain cells has been s ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health

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