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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Broad Spectrum Antiviral Nucleoside Phosphonate Analogs

    SBC: TSRL, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The Working Group for Civilian Biodefense reviewed potential biological threat agents and listed those considered to pose the greatest threat to the civilian population Variola and other orthopox DNA viruses were identified as a potential bioterrorism threat Additionally other DNA viruses are of increasing concern in a public health context due to the emerge ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Protease resistant D peptide Inhibitors of Ebola Virus Entry

    SBC: NAVIGEN, INC.            Topic: R

    DESCRIPTION provided by applicant Ebola virus causes highly lethal hemorrhagic fever in humans and non human primates Since the first outbreak in there have been over natural human outbreaks with an average mortality rate near There are no approved agents to prevent or treat Ebola infection Due to ease of dissemination high lethality and ability to cause widespread panic the ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  3. SYSTEMIC RADIONUCLIDE THERAPY TARGETED TO VEGF RECEPTORS IN TUMOR VASCULATURE

    SBC: SIBTECH, INC.            Topic: NCI

    The overall goal of this collaborative project between SibTech Inc PI Backer J and Johns Hopkins University PI Pomper M is clinical development of efficient and cost effective anti angiogenic Lu radiopharmaceutical scV Lu for VEGF receptor mediated targeting of angiogenic tumor vasculature Current very expensive anti angiogenic compounds induce transient regression of tumor vascula ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Mobile multifunctional tool for monitoring and management of respiratory diseases

    SBC: TF HEALTH CORPORATION            Topic: NHLBI

    DESCRIPTION provided by applicant Mobile multifunctional tool for monitoring and management of respiratory diseases Chronic Obstructive Pulmonary Disease COPD and asthma affect millions of people worldwide Because there is no permanent cure for these diseases efficient management of the patients is needed New mobile health technologies such as personal devices that allow patients to monit ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Electrochemically Enhanced Plasmonic Imaging for Quantitative Proteomics

    SBC: BIOSENSING INSTRUMENT INC            Topic: 400

    DESCRIPTION provided by applicant We are proposing a technology to help in three key areas of proteomics including a recognition of protein interactions b characterization of post translational modifications and c quantitative measurements at high spatial and or temporal resolution to address the dynamics of protein interactions Several significant types of protein interactions remain ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Self Applied Wearable Ultrasound Therapy for Osteoarthritis Management in Underserved Populations

    SBC: Zetroz Systems LLC            Topic: NIMHD

    DESCRIPTION provided by applicant Osteoarthritis OA is a degenerative disease of the joints which affects million Americans causing chronic pain limited mobility and overall reduction in the quality of life Americans with OA currently manage their symptoms through lifestyle changes weight loss exercise etc physiotherapy and medications to reduce pain and inflammation Although OA ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Improving Outcomes for Mechanically Ventilated Patients with the Digital EZ Board

    SBC: VIDATAK, LLC            Topic: 600

    DESCRIPTION provided by applicant Effective communication between patients and healthcare professionals is essential to achieve positive clinical outcomes Patients who are unable to communicate effectively e g patients with limited English proficiency LEP those who are hearing impaired aphasic or have oral tracheal intubation experience extreme frustration panic anxiety sleeplessne ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Development of DT-109 as an oral therapeutic for type 2 diabetes

    SBC: Diapin Therapeutics LLC            Topic: 200

    DESCRIPTION provided by applicant Type diabetes T D is chronic disease characterized by high blood glucose and rapidly emerged as a global health care problem that threatens to reach pandemic levels by Nearly million people worldwide are currently affected by diabetes Diabetes is a major cause of heart disease and stroke and also leads to other complications such as vision loss ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Biomimetic Membrane Device for Therapeutic Application in Chronic Heart Failure

    SBC: Innovative Biotherapies, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Cardiovascular disease is the leading cause of mortality in the US accounting for of all deaths Chronic Heart Failure CHF is now understood to be a multi system disease process which involves not only the cardiovascular system but also the renal neuroendocrine and immune systems There is no effective therapy currently available to treat the most seve ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. L-MOD Therapy: Leukocyte Immunomodulation during Cardiopulmonary Bypass

    SBC: Innovative Biotherapies, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant The Problem Cardiovascular disease is the leading cause of death in the Western world In the US nearly coronary artery bypass surgeries are performed annually with an estimated of these using the technique of cardiopulmonary bypass CPB CPB patients experience complications many of which are considered to be due to the activation of leukocytes ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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