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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Improving Outcomes for Mechanically Ventilated Patients with the Digital EZ Board

    SBC: VIDATAK, LLC            Topic: 600

    DESCRIPTION provided by applicant Effective communication between patients and healthcare professionals is essential to achieve positive clinical outcomes Patients who are unable to communicate effectively e g patients with limited English proficiency LEP those who are hearing impaired aphasic or have oral tracheal intubation experience extreme frustration panic anxiety sleeplessne ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Inhibitors of Multi-Drug-Resistant Mutants of BCR-ABL for the Treatment of Chronic Myelogenous Leukemia (CML) and Ph Positive Acute Lymphocytic Leukemia (ALL).

    SBC: HOUSEY PHARMACEUTICAL RESEARCH LAB            Topic: 102

    DESCRIPTION provided by applicant This is a Phase I SBIR Application entitled andquot Novel Inhibitors of Multi Drug Resistant Mutants of BCR ABL for the Treatment of Chronic Myelogenous Leukemia CML and Ph Acute Lymphocytic Leukemia ALL andquot The overall goal of this proposal is to further optimize and improve the efficacy of novel classes of compounds discovered developed and patent ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Pre-IND study of PMT-254, a pan-FLT3 inhibitor for the treatment of FLT3 driven cancers.

    SBC: PROMUTECH PHARMACEUTICALS, INC.            Topic: 102

    DESCRIPTION provided by applicant Pathological activating mutations in the FLT kinase represent the most common genetic alteration in patients with acute myeloid leukemia AML occurring in approximately one third of cases Recently we performed translational studies that identified drug resistant kinase domain mutations in FLT ITD at the time of relapse in AML patients treated with the FLT ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Application of an efficient drug repurposing platform to identify treatments for Cornelia De Lange Syndrome

    SBC: Recursion Pharmaceuticals, LLC            Topic: NICHD

    DESCRIPTION provided by applicant Cornelia de Lange Syndrome is a complex congenital malformations syndrome with many post natal progressive medical complications CdLS has a clear genetic cause with loss of function mutations in NIPBL accounting for over of the genetically confirmed CdLS cases The remaining cases exhibit mutations in subunits or regulators of the cohesion complex SMC S ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Isolation and Characterization of Low Molecular Weight Compounds Derived from Plant Extracts that Activate the IRS-2 Dependent Insulin Signaling Cascade.

    SBC: HOUSEY PHARMACEUTICAL RESEARCH LAB            Topic: 200

    DESCRIPTION provided by applicant This is a Phase I SBIR Application entitled andquot Isolation and Characterization of Low Molecular Weight Compounds Derived from Plant Extracts that Activate the IRS Dependent Insulin Signaling Cascade andquot Diabetes is a growing and significant global health concern Insulin Receptor Substrate IRS is a critical component in the insulin mediated s ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Self Applied Wearable Ultrasound Therapy for Osteoarthritis Management in Underserved Populations

    SBC: Zetroz Systems LLC            Topic: NIMHD

    DESCRIPTION provided by applicant Osteoarthritis OA is a degenerative disease of the joints which affects million Americans causing chronic pain limited mobility and overall reduction in the quality of life Americans with OA currently manage their symptoms through lifestyle changes weight loss exercise etc physiotherapy and medications to reduce pain and inflammation Although OA ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  7. POINT-OF-CARE HEMOSTASIS ANALYZER FOR THE INTEGRATED ASSESSMENT OF PLATELET AND COAGULATION FUNCTIONS

    SBC: Thrombodyne Inc            Topic: NHLBI

    DESCRIPTION provided by applicant The timely diagnosis and optimal management of hemostatic dysfunction in trauma and surgical patients is challenging due to the unavailability of suitable analytical tools The current need to conduct multiple tests with multiple blood samples on multiple devices to ascertain the specific nature of the hemostatic defect by examining the different platelet aggr ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Measuring toxicant effects on cellular function in a microarray format

    SBC: CIENCIA INC            Topic: NIEHS

    DESCRIPTION provided by applicant The EPA maintains a Toxics Release Inventory of over toxic chemicals that are disposed or released from more than industrial sites in the United States The Department of Health and Human Services and USDA maintain a list of over select agents and toxins that pose a severe risk to both human animal and plant health These compounds represent only ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Visual Ontological Language for Technical Standards (VOLTS)

    SBC: Aztera, LLC            Topic: 9010273R

    Current research shows that failures in the standardization process are often the result of a failure of the participants to communicate or organize. To this effect, NIST has developed a tool, NIST Ontological Visualization Interface for Standards (NOVIS), with an environment for visualizing, browsing, and querying standards. Aztera will create a Computer Aided Standards Development (CASD) framewo ...

    SBIR Phase I 2015 Department of CommerceNational Oceanic and Atmospheric Administration
  10. Rapid Monitoring and Assessment of Tubercuolosis Treatment at the Point of Care Using Breath

    SBC: NanoSynth Materials and Sensors Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Problem and Significance According to the CDC global statistics nearly of the world is infected with Tuberculosis TB In million f peopled infected lived in what is considered a high burden country Countries such as India Peru China sub Saharan Africa and others have significant regions endemic for TB particularly among the lower income ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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