List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 375: 18F PET Tracer For Imaging PD-L1 (Moonshot)

    SBC: SIBTECH, INC.            Topic: NCI

    New therapies, designed to enhance anti-tumor immunity are based on the blockade of the checkpoint components, either PD-1 on immune cells or PD-L1 on tumor cells. This strategy, while being spectacularly successful in some patients for some cancers, fails for many other patients. The expression of PD-L1 is highly dynamic and its prevalence within tumors can vary significantly over time. The curre ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Validating the MicroKine Assay for Use in Identifying Personalized Precision Therapies for Pediatric Sepsis

    SBC: PreDxion Bio, Inc.            Topic: NICHD

    Project Summary Abstract PreDxion BioLLC is a precision medicine diagnostic company developing an assay platformthe MicroKineassay cartridge and readerthat measures serum proteins in less thanminutes from a single drop of bloodThis fastactionable information allows for the first time individualized precision medicine aimed at reducing pediatric morbidity and mortality in pediatric sepsisthe number ...

    STTR Phase I 2018 Department of Health and Human Services
  3. Multifunctional Antioxidant to Prevent Noise-Induced Hearing Loss

    SBC: Therapeutic Vision, Inc.            Topic: NIDCD

    Noise induced hearing lossNIHLis the most common occupational disease for which no clinically effective drug is availableSince NIHL involves oxidation linked loss of sensory hair cells and auditory neurons in the cochleathere is a need for potent and effective antioxidants that offer protection to these tissuesIn preliminary studies we have observed that the orally administered multifunctional ant ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. A Noninvasive Prenatal Testing Platform for Aneuploidy at Five Weeks of Gestation

    SBC: Advanced Reproductive Testing, L.L.C.            Topic: NICHD

    The overall goal of this research is to provide a flexible prenatal genetic testing kit that can be expanded to detectany inheritable trait as early asand up toweeks of gestationfrom a safenoninvasive Pap smearStudiesshow that perinatal Pap tests pose no risk to mother or fetusand capture trophoblastlike cells that migrate fromtheplacentaintothereproductivetractTrophoblastretrievalandisolationfrom ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Targeting Exonuclease Resistant RNA to Develop Zika Virus Therapeutics

    SBC: NYMIRUM, INC.            Topic: NIAID

    Project Summary Abstract Outbreaks of Zika VirusZIKVhave been recorded in Africathe AmericasAsiaand the Pacificand despite significant resources being dedicated to combat ZIKV proliferationthere is no known cureMany mosquitoborne flavivirus such as ZIKVDengue virusYellow Fever virusand West Nile virus have structuredUTRsStructured RNA elements in theUTRs allow the virus to resist degradation by ho ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Antimicrobial Intravascular Catheter Lock Solutions Based on Endogenous Nitric Oxide Release Agent

    SBC: NOTA Laboratories LLC            Topic: NIAID

    ! AbstractIntravascularIVcatheters in the hospital setting are associated with a high rate of bacterial colonizationresulting in andgtdeaths annually in the U Sfrom catheter related blood stream infectionsCR BSIsNewer commercial catheters pre loaded with silver or antibiotics within their walls have failed to dramatically reduce this very significant problemA variety of catheter lock solutionscath ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Production and Characterization of Human Immunoglobulin Producing Goats for Diagnostic Reagents and Therapeutics

    SBC: SAB Capra LLC            Topic: NIAID

    Project Summary A research plan is proposed to engineer goats that produce fully human immunoglobulinThese animals will be evaluated as a candidate platform system for production of both targeted therapeutic immunoglobulin as well as reagent antibodies for standards and controls of serological assays of human clinical samplesPrevious studies have demonstrated that ungulates such as cattle can prod ...

    STTR Phase I 2018 Department of Health and Human Services
  8. The Kappa Partial Agonist PPL-103 as a Potential Cocaine Abuse Pharmacotherapy

    SBC: PHOENIX PHARMALABS, INC.            Topic: NIDA

    Abstract Currentlyclinically used drug abuse medications exist for treatment of addiction to opiatesalcoholand nicotinebut not cocaineThe objective of the proposed project is to test the hypothesis that the partial kappa agonist PPLcan be effective as a pharmacotherapy for treatment of cocaine abuseBecause of chronic drug induced changes in the kappa opioid receptor systemkappa receptor directed c ...

    STTR Phase I 2018 Department of Health and Human Services
  9. An antigen-detection assay to diagnose Babesia microti infection

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    Project Summary Human babesiosis is a malaria like multisystem disease caused primarily by Babesia microtian emerging apicomplexan parasite that infects and develops within human erythrocytesThe parasite is transmitted to humans by the tick vector Ixodes scapularis and can also be introduced through blood transfusionInfection can cause flu like symptomsand severe infection can be fatalin particula ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Infant NeuroLUX: A Novel Non-invasive Therapeutic Device for Neonatal Hypoxic Brain Injury

    SBC: Mitovation, Inc.            Topic: 101

    Neonatal hypoxia ischemia is a known cause of cerebral damage resulting from inadequate blood flow and or oxygen delivery to the infant brain beforeduringor after birthThe occurrence among hospital deliveries isperfull term births with a drastic increase among premature newbornsThe deficit in oxygen delivery to the brain results in extensive damage and severe disabilitiesRestoration of blood flow ...

    STTR Phase I 2018 Department of Health and Human Services

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government