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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Microbial Synthesis of Therapeutic Bile Acids for Alzheimer's Disease

    SBC: Metselex, Incorporated            Topic: 105

    ABSTRACT This Phase STTR Phase II proposal aims to engineer and scale-up a synthetic metabolic pathway in a microbial host to produce UDCA and related compounds. Additionally, the UDCA produced from the engineered synthetic metabolic pathway will be used to synthesize derivatives for testing in our Alzheimer’s Disease cell and animal models. The proposed work has high intellectual merit for the ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a treatment for durable remission of HIV using transposon engineered CAR-T and NK cells

    SBC: MARPAM PHARMA LLC            Topic: NIAID

    Project Summary MarPam Pharma aims to develop a one-time treatment for achieving durable remission of human immunodeficiency virus (HIV), after which patients will no longer need to take antiretroviral therapy. Our treatment is an autologous HIV-specific chimeric antigen receptor (CAR) immune cell therapy that employs the CXCR5 chemokine receptor as a homing device to direct either anti-HIV T cell ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Two-for-one Stroke Thrombectomy:A novel Dual DAC to enhance navigability, lumen size, aspiration efficiency, and persistent flow arrest in mechanical thrombectomy

    SBC: PIRAEUS MEDICAL, INC.            Topic: 105

    PROJECT SUMMARY/ABSTRACT The long-term goal of this proposal is to improve the care of patients suffering from Large Vessel Occlusion Acute Ischemic stroke. Currently, mechanical thrombectomy techniques can achieve revascularization in over 70% of cases, and physicians are rapidly adoption aspiration thrombectomy over stent-trievers. Aspiration maintains equivalent angiographic and clinical outcom ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. GENOMICE (Game Exploring Nuances in Offspring to Master Interactions of Chromosome Expression)

    SBC: SMART INFORMATION FLOW TECHNOLOGIES LLC            Topic: NHGRI

    PROJECT SUMMARY Genomics has become an essential element of biomedical science, playing multiple roles in rapidly addressing the COVID-19 pandemic, understanding medical complications to develop more effective preventative care and treatments, and modeling diseases in laboratory specimens for study. Despite the increasing relevance of genomics to people's everyday lives, genomics literacy in the U ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Prodrugs of potent and selective protease inhibitors as tauopathy therapeutics

    SBC: MYRIEL, INC.            Topic: 105

    PROJECT ABSTRACT Myriel, Inc., is a pharmaceutical start-up company founded in 2022 to find cures for tauopathies, including Alzheimer’s disease and related dementias (ADRD), which impair cognition in 32% of US adults 65 years and older. The goal of this Phase 1 STTR application is to provide Myriel with a brain-penetrant analogue of our lead compound, GPHR ‘739, the first potent, selective, r ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Systemic Transplantation of MyoPAXon: IND Enabling Studies for the Treatment of DMD

    SBC: MYOGENICA INC.            Topic: NIAMS

    PROJECT SUMMARY Duchenne muscular dystrophy (DMD) is the most common type of muscular dystrophy, caused due to mutations in the dystrophin gene. DMD is characterized by progressive muscle wasting and overall loss of muscle function. DMD patients become wheel chair dependant by 12 years of age and the associated cardiorespiratory complications result in their early death around 20 years of age. Dys ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. A Novel Melanoma Vaccine Based on a Shared Neoantigen and a Liquid Polymer Platform

    SBC: Trekka Therapeutics, LLC            Topic: NCI

    Abstract Despite the dramatic improvement in outcomes afforded by immune checkpoint inhibitors and targeted therapies, most patients with metastatic BRAF-mutated melanoma ultimately experience progression of their disease. One key reason for resistance to immune checkpoint inhibitors is a paucity of melanoma-specific T cells, but unfortunately, the majority of early melanoma vaccines meant to expa ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. HIDEHO: HIerarchical DistributEd Heterogenous Optimization

    SBC: SMART INFORMATION FLOW TECHNOLOGIES LLC            Topic: AF21BT001

    Large-scale military and civilian planning problems are (1) distributed – decision-making is spread across multiple organizations, including organizations that must employ information that they are unable or unwilling to share; (2) heterogeneous – the domains of optimization and local criteria for optimality differ – and (3) hierarchical – higher levels of authority solve abstract versions ...

    STTR Phase II 2023 Department of DefenseAir Force
  9. PROACTV- Projective Plan Recognition with Orbital Analysis of Conjunctive Threats and Vulnerabilities

    SBC: SMART INFORMATION FLOW TECHNOLOGIES LLC            Topic: SF22DT001

    Maintaining awareness of the space environment is a critical task for national security, one that currently relies primarily on radar and photometric data to track the thousands of active satellites and debris in Earth orbit. Despite the volumes of data a

    STTR Phase I 2023 Department of DefenseAir Force
  10. MADEIRA: Multi-Agent Debloating Environment to Increase Robustness in Applications

    SBC: SMART INFORMATION FLOW TECHNOLOGIES LLC            Topic: N23AT009

    SIFT and the University of Southern California's Information Sciences Institute (USC/ISI) propose to develop the Multi-Agent Debloating Environment to Increase Robustness in Applications (MADEIRA). MADEIRA will apply AI/ML techniques to learn how to apply diverse debloating tools, automatically reducing the attack surfaces of full systems that may include firmware, OS, container, and application-l ...

    STTR Phase I 2023 Department of DefenseNavy
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