Award Data

Modern drug discovery is facilitated by investigating, understanding and exploiting the interaction of defined molecules within complex biological systems. The interface of computational and biomolecular sciences enables the exploitation and development of new paradigms for production of vital therapeutic agents. Success in the contemporary biopharmaceutical arena will require improvements in comp ...

Our initiative to design agents to combat Plasmodium falciparum, the most debilitating of several malaria strains, combines powerful bioinformatic techniques to develop protein target structures with a multifaceted strategy for rational drug design. Using the available x-ray crystal structure of CDK2 as a structural template, we will generate and validate three-dimensional structural models of th ...

Development of three Bipropellant Tank designs with mechanically linked pistons for Advanced Small Missile Systems. The study will consider the technical and fabrication issues associated with the design, and rate the comparative merits leading to the selection of Phase II continuation.

This SBIR Phase I project is proposed to develop a highly manufacturable technology for radiation-hardened high-temperature SiC devices for both military and commercial applications. The innovative design in device structure and in processing of the proposed SiC power device will make it possible to offer the ultimate high radiation tolerance. The SiC device will also overcome the bottleneck probl ...

The field of hyperspectral imaging has undergone tremendous development in the past decade. Research and development of the hyperspectral imaging in military applications has primarily focused on air-to-ground and space-to-ground reconnaissance of stationary military targets and terrestrial backgrounds. In this SBIR program, researchers of Dymas Research propose an innovative hyperspectral imaging ...

There is no technology currently available for sorting nanoparticles by particle size. Furthermore, there is no commercially viable process for removing relatively large primary particles and aggregates from a nanopowder mass. High rate nanoparticle production processes invariably produce powders that have either a wide particle size distribution, or are aggregated. This is evidenced in the charac ...

We will design, develop, and deliver a 128x128 pixel indium gallium arsenide (InGaAs) focal plane array (FPA) camera that satisfies or exceeds all of the technical requirements of this solicitation. The use of a substrate-removed InGaAs photodiode array will exhibit high quantum efficiency from 0.4 µm through 1.7 mm. The camera will thus be usable both for visible imaging and for the imaging of ...

In response to Army SBIR Topic No. A02-232, we propose to develop a novel approach to package high power density SiC devices for high temperature operations. The proposed approach is aimed at achieving (i) substantially higher heat rejection, (ii) drastically simplified packaging technology, (iii) greatly improved reliability for high temperature operations, and (iv) low cost so that it cab find n ...

We will develop and deliver an imaging system capable of simultaneously tracking up to 8 independent objects at rates in excess of 1000 frames per second. The system will incorporate a novel indium gallium arsenide focal plane array and camera and will be sensitive to the 0.9 mm to 1.7 mm shortwave infrared wavelength band. The final deliverable will be capable of imaging multiple regions-of-int ...

Several plume-hardbody handover algorithms under development by various investigators show promise in simulations for locating the missile body when the body is resolved or approximately the size of a pixel. Several scenarios involving liquid propellant missiles, such as the cases where these threats are observed at moderate to long ranges, and are at near nose-on geometries or large angles of at ...