Award Data

THIS WORK IS DIRECTED TOWARD THE INVESTIGATION OF A NEW MEMBRANE-BASED PROCESS FOR THE SEPARATION OF ENANTIOMERS IN A RACEMIC MIXTURE. MANY BIOLOGICALLY ACTIVE SUBSTANCES ARE CHIRAL, AND IN GENERAL ONLY ONE OF THE ENANTIOMERS IN THE RACEMIC MIXTURE PRODUCES THE DESIRED BIOLOGICAL ACTIVITY. FREQUENTLY, THE UNWANTED ENANTIOMER INHIBITS THE DESIRED BIOLOGICAL ACTIVITY OF THE ACTIVE ENANTIOMER AND/OR ...

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STRIATAL TRANSPLANTATION OF NEUROTRANSMITTER CELLS, IMMUNOISOLATED WITHIN A PERMSELECTIVE POLYMER MEMBRANE CAPSULE, REPRESENTS A NOVEL APPROACH TO THE TREATMENT OF PARKINSON'S DISEASE. THE TECHNIQUE HAS HAD PROMISING RESULTS IN SEVERAL RODENT MODELS, AND PRIMATE STUDIES ARE UNDERWAY. THE OVERALL OBJECTIVE OF THIS RESEARCH IS TO COMPLETE THE DEVELOPMENTS NECESSARY FOR WIDESPREAD MEDICAL ACCEPTANCE ...

THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS THE DEVELOPMENT AND INTRODUCTION TO MEDICAL PRACTICE OF AN EFFECTIVE BIOCOMPATIBLE IMPLANTABLE HYBRID ARTIFICIAL ENDOCRINE PANCREAS THAT IS CAPABLE OF SIGNIFICANT IMPROVEMENT IN THE THERAPY OF INSULIN-DEPENDENT DIABETES. THE SPECIFIC AIM OF THIS PROJECT IS TO EXTEND AND MODIFY A PROCESS FOR CELLULAR ENCAPSULATION TO THE ISLETS OF LANGERHANS, USING A CO-E ...

ONE REASON PEOPLE POSTPONE THEIR FINANCIAL PLANNING FOR RETIREMENT IS THE INTIMIDATING ALIEN NATURE OF MANY OF THE FINANCIAL ACTIVITIES AND CONCEPTS INVOLVED. A TECHNIQUE FORALLEVIATING THIS DISTRESS, IMPARTING THE REQUISITE KNOWLEDGE AND MOTIVATING THE NECESSARY ACTION, IS TO USE A SERIES OF "MICROWORLDS". THE FIRST MICROWORLD, CHOSEN BY THE SUBJECT, SHOULD DRAW THESUBJECT INTO A COMPUTERIZED EXP ...

THE PURPOSE OF THIS PROJECT IS TO DEVELOP, FIELD-TEST, AND REFINE A MEDIA-BASED FAMILY PROGRAM TO PROMOTE HEALTHY ADOLESCENT ADJUSTMENT. PARENT/ADOLESCENT SKILLS WILL BE THE FOCUS OF VIDEOTAPES AND MANUALS THAT COULD BE USED (1) IN PREVENTION TRIALS WITH LARGE SAMPLES OF UNSELECTED OR AT-RISK FAMILIES AND (2) AS ADJUNCT MATERIALS FOR CLINICIANSTO USE IN TREATING DISTURBED FAMILIES. IN PHASE I, ONE ...

THIS PROJECT PLANS TO DEVELOP A SET OF VIDEO-BASED SKILL PROGRAMS FOR PARENTS AND YOUNG ADOLESCENTS (AGES 11 TO 14). THE PROGRAMS WILL ADAPT SOCIAL LEARNING PARENTING AND TEEN BEHAVIOR CHANGE SKILLS TO FIT THE ECOLOGICAL AND INTERPERSONAL SITUATIONS OF ETHNICALLY DIVERSE URBAN FAMILIES. TWO URBAN CONSULTATION TEAMS COMPOSED OF PARENTS,TEENS, AND COMMUNITY LEADERS WILL ASSIST IN DEVELOPING THE PROG ...

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