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Often with little knowledge of the per treatment efficiency as related to the individual patients needs, Hemodialysis is prescribed for over 400,000 patients worldwide. A methodology and apparatus are proposed for the quantification of urea removal during treatment. A prototype urea sensor will be developed based on the marriage of immobilized enzyme and ion selective electrode technologies. The s ...

The understanding of protein function is greatly enhanced by the availability of three-dimensionalinformation obtained by X-ray crystallography. Unfortunately the large, well-ordered three-dimensionX-ray analyses have been difficult to produce for membrane proteins since they tend more naturally tdimensional arrays. A further complicating factor in dealing with membrane proteins is the requiremeso ...

About 75,000,000 lbs of paint sludge is generated by the U.S. automotive industry each year. This type of waste and (similar streams from other industries) make significant contributions to landfills. The solution proposed by ASTER, Inc., proven feasible during the Phase I of this work, is to recycle the paint sludge into ingredients for automotive sealants. This new approach results in waste g ...

The research program is designed to develop a device that will restore bowel emptying and fecalcontinence in human subjects who have lost control of these functions through neurological disease ordamage such as spinal cord injury. It has been demonstrated that it is possible to activate selectivelyand independently the small parasympathetic and the large somatic nerve fibers in the sacral anterior ...

The U.S. chemical industry accounts for over 200 million tons/year of hazardousliquid waste containing organic chemicals. These waste streams are difficult totreat using conventional technologies such as carbon adsorption and steamstripping. Membrane processes--particularly pervaporation--offer energy and costadvantages over conventional techniques. However, current pervaporationmembrane-module ...

There is an increasing awareness about the problems associated with blood transfusions. One concernbacterial contamination of blood bags. If contaminated blood is transfused, the person receiving thebecoming sick and dying. Current standards require that blood be visually inspected before leaving tblood has an abnormal appearance, it is not used. This visual quality check is subject to human judgt ...

The objective of this research program is to demonstrate the feasibility of a new controlled-releasuse in an injectable formulation of buprenorphine to improve treatment of opioid dependence. The keytechnology is the use of bioerodible microporous microbeads with a controllable structure that allowas well as easily varied release rates and durations of release. These controlled-release microbeadsi ...

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