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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. GreenCare Interactive Guide for Knee Replacement Surgery

    SBC: PEER Technologies PLLC            Topic: NIA

    Project SummaryAbstract The goal of this Phase I work is to finish development of an innovative interactive app designed to help patients appropriately use total knee replacementTKRsurgery and provide support to achieve best outcomesTKR is highly effective for treating advanced osteoarthritis of the kneebut it has risksAppropriate use can be assured by engaging patients in a Shared Decision Making ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. A universal eye drop adherence monitor to measure and improve adherence to ocular medications

    SBC: Universal Adherence LLC            Topic: N

    Project Summary Abstract Universal Adherence is an emerging medical device company dedicated to improving adherence to ocular medications through innovative technical solutionsOur proposed Devers Drop DeviceDwill accurately track when a patient removes an eye drop bottle capcommunicate usage data wirelessly to a database that researchers can accessand send alerts to patients when a medication is d ...

    STTR Phase I 2018 Department of Health and Human Services
  3. Development of a Yellow Fever Vaccine for a Vulnerable Population

    SBC: NAJIT TECHNOLOGIES, INC.            Topic: NIAID

    ABSTRACT Yellow fever virusYFVrepresents a mosquito borne emerging re emerging human pathogen that causesmortality and is endemic in andgtcountriesThe current live attenuated YFV vaccine was developed inand following the establishment of a virus seed lot systemit has not been modified or otherwise improved in overyearsAccording to the CDCthis vaccine causesserious adverse eventsSAEper million vacc ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. Adaptable Pediatric Neurocognitive Assessment

    SBC: CREARE LLC            Topic: 103

    PROJECT SUMMARY ABSTRACTMillions of children around the globe are afflicted with conditions that can alter neuropsychological developmentincluding human immunodeficiency virusHIVtraumatic brain injuryTBIcerebral malariaand a host of other developmental and acquired diseases and disordersEarly assessment and intervention are critical in overcoming cognitive and developmental deficiencies and are in ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. Advancing Human Health by Lowering Barriers to Electrophysiology in Genetic Model Organisms

    SBC: NEMAMETRIX, INC            Topic: 300

    Project Summary The nematode worm Caenorhabditis elegans has proven valuable as a model for many high impact medical conditionsThe strength of Celegans derives from the extensive homologies between human and nematode genesand the many powerful tools available to manipulate genes in Celegansincluding expressing human genesResearchers utilizing medical models based on Celegans have converged on two ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Factor XI inhibitor for thrombosis

    SBC: Aronora, Inc            Topic: NHLBI

    Project Summary Although potent antithrombotic agents are availableall of these drugs inadvertently target vital hemostatic molecular mechanismsresulting in dose limiting hemorrhagic toxicity that restrict their useDue to a lack of safe thromboprophylaxisthrombotic blood vessel occlusions continue to be extremely prevalentand result in a wide range of severe disease conditions that remain the lead ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. Development of CM-SV1, a monoclonal antibody treatment for Sudan Virus

    SBC: CELDARA MEDICAL, LLC            Topic: NIAID

    PROJECT SUMMARY The filovirusesfamily Filoviridaecomprising five ebolavirusesa cuevavirusand two Marburg virusesare negative strand RNA viruses that cause severe hemorrhagic fever with up tohuman case fatality rateTheepidemic in Western Africacaused by the Zaire ebolavirusEBOVspecies demonstrated the potential for these viruses to cause dire health emergencies of global scopeand highlighted the ne ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Targeting leukocyte metabolism to treat human autoimmune disease

    SBC: Immunext, Inc.            Topic: R

    ImmuNext has defined an anti MCTmonoclonal antibodymAbthat will be developed for the treatment of human autoimmune diseaseThe membrane monocarboxylate nutrient transporter SLCAMCTis a multi pass transmembrane protein responsible for the facilitated transport of critical metabolitesincluding products of glycolysislactatepyruvate and ketonesOur strong preliminary data support the tenet that mAbs tha ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Smart Cavity Creator Drill for Lumbar Interbody Fusion

    SBC: PEER Technologies PLLC            Topic: NIBIB

    PROJECT SUMMARYABSTRACT Older patients with persistent and progressive symptoms of chronic back pain and leg pain often have a diagnosis of lumbar degenerative spondyolisthesis and undergo complex lumbar decompression and fusion surgeryOverof these procedures are performed in the United States each yearSurgery is highly effective but technically challengingOne technical challenge of fusion in spon ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Mobility Rehab: A Biofeedback System for Mobility Rehabilitation for Older Adults

    SBC: APDM, INC.            Topic: NIA

    Project Summary Mobility limitations including gait and balance impairments are common in older adultsespecially those with neurological de citsGait and balance impairments are a major cause of falls and reduced quality of lifeAlthough laboratory studies show that biofeedback during exercise training can improve motor performancephysical therapists do not have access to an overground gait biofeedb ...

    SBIR Phase II 2018 Department of Health and Human Services

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