Award Data

DESCRIPTION (provided by applicant): Pressure ulcers affect approximately 1.7 million patients in the U.S. The overall cost to the healthcare industry for treating pressure ulcers in the U.S. is estimated to exceed $7 billion, and it is well established that the cost of preventing a pressure ulcer is significantly less than its treatment. Skin breakdown is frequently seen in individuals with bot ...

DESCRIPTION (provided by applicant): This proposal aims to evaluate the efficacy of Native American ethnobotanical treatments for tuberculosis for the purpose of making available acceptable, affordable alternatives to current TB drugs, especially in developing countries with massive TB case loads such as the People's Republic of China. No new drugs have been introduced for the treatment of tuberc ...

DESCRIPTION (provided by applicant): Prostate cancer is the second leading cause of cancer death in US men. Prostate cancer is highly dependent on androgen stimulation mediated through the androgen receptor (AR) for growth and proliferation. For those with advanced PCa, androgen ablation remains the foundation of therapy. Current methods of androgen ablation focus on diminishing circulating and ...

DESCRIPTION (provided by applicant): The broad, long-term objectives of the application are to develop antisense inhibitors of retinopathy and document their mechanism(s) of action. Retinopathy is a significant cause of eye disease and has a major impact on development, learning, communicating, working, health, and quality of life for affected individuals. This application focuses on the inhibitio ...

DESCRIPTION (provided by applicant): Cayuse, Inc., has previously developed software (GrantSlam) which is used by thousands of investigators to create their paper-based NIH grant proposals. In so doing, they are simultaneously collecting data for ERA submission of their applications. The current version of GrantSlam has the solid beginnings of an ERA solution and Cayuse wants very much to extend i ...

DESCRIPTION (provided by applicant): The development of comprehensive, accurate, and low-cost systems to monitor the well being of children and adolescents is a fundamental prerequisite to achieving a healthy society. We will design and create an Internet based decision-support system that incorporates data from the Oregon Healthy Teens and other public domain data sources related to the health a ...

DESCRIPTION (provided by investigator): Fetal alcohol syndrome (FAS) is a leading cause of developmental disability in the Western world, and is entirely preventable. Still, 20% of women who drink continue to do so during pregnancy. Efforts at prevention have failed to access many high-risk women in time to intervene effectively, A venue frequently visited by drinking gravidas (pregnant women) i ...

DESCRIPTION (provided by investigator): The proposed project will develop a computer-based tobacco prevention program for middle school students. This program is designed as a curriculum component for 6th through 8th grade teachers who provide tobacco prevention instruction. The Phase I CD-ROM prototype will deliver engaging media to educate students about the risks of tobacco and peer and indust ...

DESCRIPTION (provided by applicant): The objective of this Phase I project is to test and develop, using primate coronary artery vascular muscle cells in vitro, a novel estrogen receptor beta (ERbeta) selective (over ERalpha) agonist that is highly effective for protecting coronary arteries against hyperreactivity and also for relieving cardiovascular menopausal symptoms of ovarian steroid deficie ...

DESCRIPTION (provided by applicant): Our goal is to develop a computerized algorithm for the electrocardiogram (ECG) that will facilitate the reliable and early detection of acute myocardial infarction (AMI). The widely recognized value of thrombolytic therapy when delivered early in the management of patients with acute MI has made the development of such an algorithm especially important. Cur ...