Award Data

DESCRIPTION provided by applicant A Phase II SBIR program of preclinical development is proposed for the development of an active specific immunotherapeutic called Cellariumandquot for treatment of glial cell based cancers Successful completion of this project will confirm therapeutic effect and pre clinical safety of the vaccine in preparation for first in human studies Upon demonstration of ...

Technological advances have facilitated weapons systems capable of simultaneously supporting multiple missions leading to cost efficiencies and greater operational flexibility.Future systems capable of deploying multiple payloads from a single missile will enable various targets to be attacked with a single launch allowing more efficient use of limited and valuable resources.For such a system to w ...

Current focal plane array (FPA) technologies for imaging in low-light conditions in the short wave infrared (SWIR) are limited by poor quantum efficiency and/or poor noise characteristics. To address this need, a new SWIR-sensitive linear-mode avalanche photodiode detector array, will be optimized for low-light imaging, fabricated, and demonstrated. Unlike existing SWIRavalanche photodiodes (APDs) ...

A 1280 x 1024, 12-micron-pitch format radiation-hardened dual-band digital infrared readout integrated circuit (ROIC) will be developed. The features of the reconfigurable adaptive detector integrated circuit (RadIC) include: low-noise in-pixel amplifiers, in-pixel analog-to-digital conversion (ADC), extended > 22-bit dynamic range with temporal-photon flux-rate encoding, high-rate readout, and as ...

DESCRIPTION provided by applicant Trichomonas vaginalis is the causative agent of the most common non viral sexually transmitted infection with million new cases reported annually in the world and million cases in the U S In addition to infections of the urogenital tract trichomoniasis increases the risk of adverse pregnancy outcomes and HIV transmission and increases the incidence ...

DESCRIPTION provided by applicant Our laboratory discovered and is developing partial p MHC class II constructs pMHC as a possible immunotherapy for multiple sclerosis MS pMHC containing the extracellular domains of the MS risk factor HLA DR linked covalently to the encephalitogenic peptide of myelin oligodendrocyte glycoprotein pDR MOG can reverse CNS inflammation and ...

DESCRIPTION provided by applicant The drug development pipeline is plagued by unacceptable rates of attrition due in large part to toxicities that are not identified in pre clincal stages of development The ability to de risk lead compounds during pre clinical development with advanced andquot organoid on a chipandquot technologies show tremendous promise Chemotherapeutics in particular whi ...

DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

DESCRIPTION provided by applicant The primary goal of this Phase I pediatric oncology clinical trial will be to evaluate the safety and use of demethyl cholesteryloxycarbonylpenclomedine DM CHOC PEN as anticancer therapy for children with advanced cancer involving the central nervous system CNS DM CHOC PEN is a polychlorinated pyridine cholesteryloxycarbonate that crosses the blood br ...

DESCRIPTION provided by applicant The nematode Caenorhabditis elegans is a powerful experimental system that is widely used as a model for a large number of high impact medical conditions from aging and metabolic disorders to neurodegenerative diseases The strength of this microscopic worm as a medical model derives from the extensive genetic homology between nematodes and humans together ...