Award Data

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The requirements of complex sample monitoring present a growing need for a new generation of highlyenzyme electrodes that operate in non-processed or raw samples and have multi-analyte capability. This to establish the feasibility of novel colloidal gold/immobilized enzyme based raw sample/multi-anspecific objective is to develop a biosensor that can measure high density lipoproteins in whole bloe ...

A MAJORITY OF VIRUSES AFFLICTING HUMANS AND LIVESTOCK HAVE RNA GENOMES WHICH ARE BELIEVED TO EXIST IN A DUPLEX A CONFORMATION DURING REPLICATION. SUCH LONG A-FORM DUPLEXES WHICH HAVE BEEN CHARACTERIZED AT ATOMIC RESOLUTION, ARE UNIQUE TO VIRUS-INFECTED CELLS (UNINFECTED CELLS HAVE ONLY SHORT A-FORM STRUCTURES) AND THEREFORE OFFER EXCELLENT WELL-CHARACTERIZED TARGETS FOR PROSPECTIVE ANTIVIRAL AGENT ...

THIS GRANT AWARD IS FOR THE DEVELOPMENT OF A NON-INVASIVE BEDSIDE MONITOR OF PULMONARY ARTERIAL PRESSURE IN INFANTS. THE PRINCIPLE OF OPERATION IS DERIVED FROM EARLIER NON-INVASIVE RESEARCH ON HUMANS AND FROM INVASIVE STUDIES ON DOGS, IN WHICH AN IMPROVED METHOD OF NON-INVASIVE DETECTION OF THE TIME OF CLOSURE OF THE AORTIC AND PULMONARYVALVES HAS BEEN DEVELOPED. THE TECHNIQUE DEPENDS ON THE DETEC ...

There is an increasing awareness about the problems associated with blood transfusions. One concernbacterial contamination of blood bags. If contaminated blood is transfused, the person receiving thebecoming sick and dying. Current standards require that blood be visually inspected before leaving tblood has an abnormal appearance, it is not used. This visual quality check is subject to human judgt ...

The objective of this research program is to demonstrate the feasibility of a new controlled-releasuse in an injectable formulation of buprenorphine to improve treatment of opioid dependence. The keytechnology is the use of bioerodible microporous microbeads with a controllable structure that allowas well as easily varied release rates and durations of release. These controlled-release microbeadsi ...

We will develop and test a model by which health plan report card information is disseminatedto publicly-sponsored consumers to use in selecting health care systems/plans. The model willincorporate a decision-making paradigm enabling Medicaid and Medicare beneficiaries to integratepersonal values/preferences, medical histories, etc. with features of health plans. Model developmentwill use both pri ...

Phase I is directed at the development of a rapid and quantitative diagnostic immunoassay for acuteinjury. This immunoassay will utilize a proven dry chemistry test system incorporating a cardiac-spechemically conjugated to active-site inactivated coagulation factor Xa. The test principle involvespeptide- Xa and blood troponin for an insolublized anti-troponin monoclonal antibody in the first stfo ...