Award Data

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We will develop a new approach to the evaluation of microregional circulation. This research is based on the working hypothesis that fluorescent microspheres can be spatially located by fluorescence imaging of organ serial sections. The project will develop instrumentation and procedures to evaluate regional flow in an entire organ. During Phase I, a computer-controlled imaging system will be asse ...

The long term goal is to develop noninvasive optical instruments and methods for assessing the functional integrity of cold-stored livers prior to transplant. In hypothermically-stored livers, areas of dysfunctional oxidative metabolism can be detected noninvasively using spectrophotometric methods. Fluorescence detection of NADH and visible light reflectance detection of cytochrome redox changes ...

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There is an increasing awareness about the problems associated with blood transfusions. One concernbacterial contamination of blood bags. If contaminated blood is transfused, the person receiving thebecoming sick and dying. Current standards require that blood be visually inspected before leaving tblood has an abnormal appearance, it is not used. This visual quality check is subject to human judgt ...

The objective of this research program is to demonstrate the feasibility of a new controlled-releasuse in an injectable formulation of buprenorphine to improve treatment of opioid dependence. The keytechnology is the use of bioerodible microporous microbeads with a controllable structure that allowas well as easily varied release rates and durations of release. These controlled-release microbeadsi ...

We will develop and test a model by which health plan report card information is disseminatedto publicly-sponsored consumers to use in selecting health care systems/plans. The model willincorporate a decision-making paradigm enabling Medicaid and Medicare beneficiaries to integratepersonal values/preferences, medical histories, etc. with features of health plans. Model developmentwill use both pri ...