Award Data

DESCRIPTION (provided by applicant): The long-range goal of this project is to restore functional movement to low-functioning stroke patients using a novel therapeutic regimen and robotic device called AMES, an acronym for Assisted Movement with Enhanced Sensation. In AMES-as it is currently used-the patient's affected limb is moved cyclically with the AMES robotic device while the sensation of ...

DESCRIPTION (provided by applicant): Stuttering is a communication disorder characterized by disfluencies that are frequent and disruptive to communication. Clinicians extensively use disfluency counts to decide whether a client should be treated, to assess treatment progress, and to document treatment outcomes. Clinicians often do disfluency counts in real-time as a speaker is talking. However, ...

DESCRIPTION (provided by applicant): Language and communication problems critically characterize a number of neurodevelopmental disorders including Developmental Language Disorders (DLD) and Autism Spectrum Disorders (ASD). It is increasingly recognized that assessment should include spontaneous natural language samples. There are measures, such as the Index of Productive Syntax (IPSyn), which are ...

DESCRIPTION (provided by applicant): Our objective is to develop new drug treatments for the side effects of levodopa (L-DOPA) that occur in people with Parkinson's Disease. L-DOPA is the gold standard of treatment for Parkinson's, but unfortunately, the majority of people who take L-DOPA eventually develop debilitating side effects, abnormal involuntary movements called dyskinesias, which may aff ...

DESCRIPTION (provided by applicant): Multiple reaction monitoring (MRM) is a highly selective, high sensitivity mass spectrometry mode for detecting the presence of particular species in a mixture. In the pharmaceutical industry, many small molecule analytes (e.g. drug metabolites, hormones, and pesticides) are routinely measured in high throughput with MRM's great precision. MRM based assays are ...

DESCRIPTION (provided by applicant): Major health disparities in chronic disease control and outcomes exist among Latinos, the fastest growing segment of the U.S. population. If these disparities continue, demographic trends will magnify their adverse health, societal, and economic impact. Chronic disease control often requires successful management of multiple prescription medications, yet many p ...

DESCRIPTION (provided by applicant): Roughly 500,000 cancer patients are treated with radiotherapy each year. Acute and late sequelae of radiotherapy have a negative impact upon the quality of life of cancer survivors. These sequelae include proctitis, cystitis, esophageal stricture, cutaneous fibrosis plus others. We propose a novel means of preventing the acute and late radiation injury to norma ...

DESCRIPTION (provided by applicant): The long-term goal of this application is to develop mannan derived from Baker's yeast as asthma therapy. The limitations of currently available immunomodulators are their toxicity at higher doses and the lack of beneficial effect on airway smooth muscle (ASM) remodeling and therefore, new adjunctive therapeutics are needed. Initial findings in the P.I.'s labor ...

DESCRIPTION (provided by applicant): Responsible beverage service (RBS) training originated some quarter century ago to prevent driving under the influence among patrons of public drinking establishments, from which half of DUI arrests and alcohol-related crashes originate. These programs train licensed servers of alcohol regarding medical and legal risks of providing and consuming alcohol. This p ...

DESCRIPTION (provided by applicant): In the past decade, elementary school settings have been overwhelmed by increasing numbers of behaviorally at-risk children who are unresponsive to the minimal but necessary demands of schooling. It is of critical importance to get behaviorally at-risk children off this trajectory or pathway as soon as possible in their school careers through early, coordinated ...