Award Data

DESCRIPTION (provided by applicant): The response of lymphocytes to antigen stimulation is characterized by proliferation of an antigen-sensitive lymphocyte population, subsequent differentiation to subsets with effector cell function, and ultimately the retention of antigen-responsive lymphocytes with a memory cell phenotype. The initial increase of responsive lymphocytes is followed by an equall ...

DESCRIPTION (provided by applicant): AVI BioPharma has been developing an antisense phosphorodiamidate morpholino oligomer, AVI-4020 for the treatment of West Nile Virus. AVI-4020 has been shown both to reduce viral titer, and to cross the blood brain barrier. This compound targets the translation start site of the single open reading frame of WNV. Studies to date indicate AVI-4020 is a reasonabl ...

Multi-axis fiber grating strain sensors may be used to localize and qualitatively identify the degree of damage in composite parts. Signatures associated with delaminations and damage tow material are significantly different for strain imaging produced data. This Phase I project is directed toward improving the quantitative measurement capability of "strain imaging" methods through experiments, ...

Missile defense battle management is an inherently distributed process, involving sensors, weapons, and targets that are distributed over a region spanning thousands of miles. While most agents need some sense of "distant events", they neither need nor can afford detailed, high-fidelity models of the entire situation. CleverSet's approach to distributed battle management is based in variable reso ...

DESCRIPTION (provided by applicant): This application encompasses those activities required to complete development of a Decision Support System for Youth Well-Being (DSS-YWB), a web-based application designed to help meet the needs of those who manage programs that influence the prevalence of healthy and harmful adolescent behaviors. The Phase I prototype DSS-YWB is based on the concept of a feed ...

DESCRIPTION (provided by applicant): Fetal Alcohol Syndrome is the leading preventable cause of developmental disabilities in the Western world, but some 20 percent of American women and 40 percent of the heavy drinkers among them continue to consume alcohol during pregnancy. Efforts thus far at prevention have employed "universal" methods such as warning labels on alcoholic beverage containers ...

DESCRIPTION (provided by applicant): Our objective is to demonstrate the removal of dark current from raw images using synthetic dark frames. In CCD and CMOS sensors, dark current varies with sensor temperature and integration time. In many science applications, however, sensor temperature is either not known or not controlled, resulting in inaccurate subtraction of dark frames and greater imag ...

DESCRIPTION (PROVIDED BY APPLICANT): Electroencephalography (EEG) is a safe, noninvasive technique for monitoring neonatal brain function. Acute and long-term EEG monitoring of infants has clinical utility for evaluating the effects of hypoxic ischemic insults and detecting the presence of epileptic activity. Medical intervention may be effective for several neonatal brain pathologies if these are ...

DESCRIPTION (provided by applicant): Electrophysiologic recording provides inexpensive and non-invasive monitoring of both normal and pathological human brain function. With a saline-sponge technology, a dense array of 64,128, or 256 electrodes can be applied in a few minutes, allowing electroencephalographic (EEG) recording in emergency and intensive care settings. However, EEG evaluations in dem ...

DESCRIPTION (provided by applicant): The goal of this research is to create custom analog VLSI semiconductor technology to provide a lightweight, compact implementation of a data acquisition system for ambulatory EEG recording using EGFs Geodesic Sensor Net, an electrode system noted for its comfort and ease of installation even with very high channel counts (to 256 electrodes). Recent high-perfo ...